Patents Assigned to Oriel Therapeutics, Inc.
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Patent number: 10493222Abstract: Methods of fabricating and operating dry powder inhalers that include dose disks and airway channel disks with sealant layers, the airway channel disks forming radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.Type: GrantFiled: February 6, 2017Date of Patent: December 3, 2019Assignee: Oriel Therapeutics, Inc.Inventors: Rachel Striebig, Matthew Allen, Thomas W. Ruckdeschel, Charles A. Buckner, III, Scott Alexander Lewis, Andrew Murray Gow, Jonathan David Tuckwell
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Patent number: 9889953Abstract: Dosing heads for apparatus for dispensing a defined amount of dry powder concurrently to a plurality of spaced apart dose receiving containers include a plurality of spaced apart elongate channels having a channel length with an upper end defining an entry orifice and a lower end defining an exit port. In use, the dosing heads are aligned with a dry powder bed residing above and in communication with the dosing head and at least one vibration source in communication with the dosing head channels configured to controllably apply a vibration flow signal. When the vibration flow signal is applied to the dosing head channels, dry powder from the dry powder bed flows through the elongate channels and out the exit port and when the flow signal is removed, dry powder does not flow through the dosing head elongate channels.Type: GrantFiled: February 2, 2016Date of Patent: February 13, 2018Assignee: Oriel Therapeutics, Inc.Inventors: James R. Meckstroth, Anthony James Hickey
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Patent number: 9795749Abstract: A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.Type: GrantFiled: February 12, 2015Date of Patent: October 24, 2017Assignee: Oriel Therapeutics, Inc.Inventors: Gerald A. Thoe, James G. Skakoon, David A. Schuelke, Thomas W. Ruckdeschel, David Harris, Scott Alexander Lewis, Andrew Murray Gow, Jonathan David Tuckwell
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Patent number: 9597465Abstract: Methods of fabricating and operating dry powder inhalers that include dose disks and airway channel disks with sealant layers, the airway channel disks forming radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.Type: GrantFiled: January 24, 2014Date of Patent: March 21, 2017Assignee: Oriel Therapeutics, Inc.Inventors: Rachel Striebig, Matthew Allen, Thomas W. Ruckdeschel, Charles A. Buckner, III, Scott Alexander Lewis, Andrew Murray Gow, Jonathan David Tuckwell
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Patent number: 9339616Abstract: Dry powder inhalers include electronic displays, readers and/or counters that can decrement dose amounts, inhibit misuse, read data on drug containment devices and/or communicate with remote devices. The dry powder containers can include at least a pair of cooperating generally tubular members, including an inner member and a generally tubular outer member sized and configured to slidably receive the inner member.Type: GrantFiled: June 6, 2012Date of Patent: May 17, 2016Assignee: Oriel Therapeutics, Inc.Inventors: John Denny, Michael King, Patrick D. Lopath, Jeffrey Alan Warden
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Patent number: 9278767Abstract: Apparatus for dispensing a defined amount of dry powder concurrently to a plurality of spaced apart dose receiving containers include: (a) a dosing head comprising a support body with a plurality of spaced apart elongate channels having a channel length with an upper end defining an entry orifice and a lower end defining an exit port; (b) a dry powder bed residing above and in communication with the dosing head; and (c) at least one vibration source in communication with the dosing head channels configured to controllably apply a vibration flow signal, wherein, when the vibration flow signal is applied to the dosing head channels, dry powder from the dry powder bed flows through the elongate channels and out the exit port and when the flow signal is removed, dry powder does not flow through the dosing head elongate channels.Type: GrantFiled: March 21, 2014Date of Patent: March 8, 2016Assignee: Oriel Therapeutics, Inc.Inventors: James R. Meckstroth, Anthony James Hickey
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Patent number: 9050427Abstract: Dry powder inhalers and methods are provided that facilitate deagglomeration of powdered medicament during inspiration. A dry powder inhaler includes a dry powder medicament container assembly, and an elongated dry powder delivery tube having an inlet at one end that communicates with a dose container, and an outlet or inhalation port that extends from the inhaler housing at an opposite end. The delivery tube includes one or more apertures adjacent the inlet that cause cyclonic or turbulent airflow through the delivery tube. The inner surface of the delivery tube has a polygonal configuration and the cyclonic air stream bounces off the polygonal inner surface numerous times as the air stream flows through the delivery tube. Another dry powder inhaler includes a deagglomeration chamber with a polygonal inner surface. An air stream containing dry powder medicament is directed into the deagglomeration chamber and impacts the polygonal inner surface numerous times.Type: GrantFiled: September 25, 2009Date of Patent: June 9, 2015Assignee: Oriel Therapeutics, Inc.Inventors: David Harris, George McGee Perkins, John Kenneth Hainsworth, Charles A. Buckner, III
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Patent number: 9027551Abstract: Inhalers with fins that deagglomerate dry powder using inspiratory effort of a user of an inhaler. The inhaler fins, at least in steady state conditions, are configured to generate dry powder and airflow patterns having turbulence with flow vortices, some of which may have a vortex having an axis of rotation that extends in an inspiratory flow direction while others may have a vortex that is substantially orthogonal to the inspiratory flow direction in an inspiratory airflow path, as an amount of dry powder travels through the inhaler to thereby deagglomerate the dry powder without trapping undue amounts of the dry powder during inhalation.Type: GrantFiled: January 4, 2013Date of Patent: May 12, 2015Assignee: Oriel Therapeutics, Inc.Inventors: Michael King, Jeffrey Alan Warden, Patrick D. Lopath, Richard D. LaRoche
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Patent number: 8991391Abstract: Dry powder inhalers are described with an inhaler body defining an enclosed cavity space and at least one of (a) an endless strip having opposing primary surfaces, the strip comprising a plurality of spaced apart blisters or dose containers holding dry powder medicament. The inhaler also has an inhalation exit flow path in the inhaler body in communication with at least one blister or at least one dose container held by the strip in a dispensing position and a piercer configured to release dry powder medicament from the blister or dose container in the dispensing position.Type: GrantFiled: September 25, 2009Date of Patent: March 31, 2015Assignee: Oriel Therapeutics, Inc.Inventors: George McGee Perkins, Scott Alexander Lewis, Andrew Murray Gow, David Harris
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Patent number: 8985103Abstract: A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.Type: GrantFiled: January 18, 2013Date of Patent: March 24, 2015Assignee: Oriel Therapeutics, Inc.Inventors: Gerald A. Thoe, James G. Skakoon, David A. Schuelke, Thomas W. Ruckdeschel, David Harris, Scott Alexander Lewis, Andrew Murray Gow, Jonathan David Tuckwell
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Patent number: 8887722Abstract: Inhalers with an inhaler housing having a dose container disk having inner and outer perimeters mounted in the housing. The dose container disk has a plurality of circumferentially spaced apart dose containers with dry powder therein. The inhalers also include a piercer carriage with a piercer mounted in the inhaler. The piercer carriage is in communication with a resilient member that radially biases the piercer carriage to radially travel to align the piercer with an underlying or overlying dose container.Type: GrantFiled: September 25, 2009Date of Patent: November 18, 2014Assignee: Oriel Therapeutics, Inc.Inventors: Thomas W. Ruckdeschel, David Harris
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Publication number: 20140202582Abstract: Apparatus for dispensing a defined amount of dry powder concurrently to a plurality of spaced apart dose receiving containers include: (a) a dosing head comprising a support body with a plurality of spaced apart elongate channels having a channel length with an upper end defining an entry orifice and a lower end defining an exit port; (b) a dry powder bed residing above and in communication with the dosing head; and (c) at least one vibration source in communication with the dosing head channels configured to controllably apply a vibration flow signal, wherein, when the vibration flow signal is applied to the dosing head channels, dry powder from the dry powder bed flows through the elongate channels and out the exit port and when the flow signal is removed, dry powder does not flow through the dosing head elongate channels.Type: ApplicationFiled: March 21, 2014Publication date: July 24, 2014Applicant: Oriel Therapeutics, Inc.Inventors: James R. Meckstroth, Anthony James Hickey
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Patent number: 8776840Abstract: Tubular dry powder feed systems in communication with a hopper of dry powder are configured with an in-line actuator that applies a flow vibration signal axially. The flow vibration signal can be a harmonic or non-harmonic signal, such as a sinusoidal, saw tooth, square wave or other signal and may be frequency or amplitude modulated.Type: GrantFiled: February 17, 2011Date of Patent: July 15, 2014Assignee: Oriel Therapeutics, Inc.Inventor: James R. Meckstroth
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Patent number: 8720497Abstract: Apparatus for dispensing a defined amount of dry powder concurrently to a plurality of spaced apart dose receiving containers include: (a) a dosing head comprising a support body with a plurality of spaced apart elongate channels having a channel length with an upper end defining an entry orifice and a lower end defining an exit port; (b) a dry powder bed residing above and in communication with the dosing head; and (c) at least one vibration source in communication with the dosing head channels configured to controllably apply a vibration flow signal, wherein, when the vibration flow signal is applied to the dosing head channels, dry powder from the dry powder bed flows through the elongate channels and out the exit port and when the flow signal is removed, dry powder does not flow through the dosing head elongate channels.Type: GrantFiled: February 17, 2011Date of Patent: May 13, 2014Assignee: Oriel Therapeutics, Inc.Inventors: James R. Meckstroth, Anthony James Hickey
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Patent number: 8671938Abstract: Dry powder inhalers include radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.Type: GrantFiled: January 7, 2013Date of Patent: March 18, 2014Assignee: Oriel Therapeutics, Inc.Inventors: Rachel Striebig, Matthew Allen, Thomas W. Ruckdeschel, Charles A. Buckner, III, David Harris, Scott Alexander Lewis, Andrew Murray Gow, Jonathan David Tuckwell
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Patent number: 8646446Abstract: Dry powder inhalers with rotatable piercing mechanisms facilitate the use of dose container assemblies having dose containers arranged in concentric rows. A piercing mechanism is operably associated with the dose container assembly and is configured to pierce sealants that seal a dose container. The piercing mechanism is rotatable such that it can serially alternate between the two rows of dose containers. The piercing mechanism includes a rotatable drum, an elongate piercing member, and a biasing member operably associated with the piercing member. The rotatable drum has an open end, an opposite closed end, and a cylindrical wall that extends from the closed end and terminates at the open end. The closed end includes an aperture formed therein in a location adjacent to the wall. The elongate piercing member is extended and retracted through the aperture to pierce the sealants of a dose container.Type: GrantFiled: September 25, 2009Date of Patent: February 11, 2014Assignee: Oriel Therapeutics, Inc.Inventors: Scott Alexander Lewis, Andrew Murray Gow, Jonathan David Tuckwell, Greg Beard, David Harris
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Patent number: 8550071Abstract: Dry powder inhalers include radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.Type: GrantFiled: September 25, 2009Date of Patent: October 8, 2013Assignee: Oriel Therapeutics, Inc.Inventors: Rachel Striebig, Matthew Allen, Thomas W. Ruckdeschel, Charles A. Buckner, III, David Harris, Scott Alexander Lewis, Andrew Murray Gow, Jonathan David Tuckwell
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Patent number: D710002Type: GrantFiled: May 8, 2012Date of Patent: July 29, 2014Assignee: Oriel Therapeutics, Inc.Inventors: Andrew J. Valentine, Charles A. Buckner, III
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Patent number: D711528Type: GrantFiled: May 7, 2013Date of Patent: August 19, 2014Assignee: Oriel Therapeutics, Inc.Inventors: Jerome A. Grunstad, Charles Buckner, Cyan Godfrey, Daniel Deaton, Andrew J. Valentine, Margaret F. Butler, Thomas W. Ruckdeschel
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Patent number: D745660Type: GrantFiled: June 25, 2014Date of Patent: December 15, 2015Assignee: Oriel Therapeutics, Inc.Inventors: Jerome A. Gruntad, Charles Buckner, Cyan Godfrey, Daniel Deaton, Andrew J. Valentine, Margaret F. Butler, Thomas W. Ruckdeschel