Abstract: A cosmetic composition to prevent and/or ameliorate skin aging and applications thereof are provided in the present disclosure and the cosmetic composition comprises cyclic phosphatidic acid and citrus flavonoids which is hesperidin and/or hesperetin wherein the preventing and/or ameliorating skin aging include, without limitation, promoting moisture retention of stratum corneum, promoting skin elasticity, increasing presence or elasticity of collagens and elastins in fibroblasts, increasing transfers of fibroblasts, promoting anti-oxidation, increasing generation of hyaluronic acid, alleviating wrinkles and skin textures, moderating melanin, reducing skin oil and preventing transepidermal water losses.

Abstract: The present invention is directed to therapeutic methods and compositions for treating type 1 diabetes in a subject comprising administering an effective amount of borapetoside A or C, or a pharmaceutically acceptable salt, metabolite, solvate or prodrug thereof, and insulin to said subject.

Abstract: The present invention is directed to therapeutic methods and compositions for treating insulin resistant diabetes or diabetes with inflammation in a subject comprising administering an effective amount of borapetoside A, or a pharmaceutically acceptable salt, metabolite, solvate or prodrug thereof, to said subject.