Abstract: The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.
Type:
Application
Filed:
April 23, 2012
Publication date:
December 27, 2012
Applicant:
Origenis GmbH
Inventors:
Michael Thormann, Andreas Treml, Michael Almstetter, Nadine Traube
Abstract: The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases.
Type:
Application
Filed:
April 23, 2012
Publication date:
December 27, 2012
Applicant:
Origenis Gmbh
Inventors:
Michael Thormann, Andreas Treml, Michael Almstetter, Roland Koestler, Nasser Yehia