Patents Assigned to Orion Corporation
  • Transmucosal veterinary composition comprising detomidine
    Patent number: 8309591
    Abstract: The present invention relates to a veterinary composition in a semisolid form adapted for transmucosal administration for providing sedation and analgesia in large animals such as horses and cattle. The semisolid transmucosal composition of the invention comprises detomidine or a pharmaceutically acceptable salt thereof as an active ingredient. The composition provides a rapid onset of action while having low irritation potential in the oral mucosa.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: November 13, 2012
    Assignee: Orion Corporation
    Inventors: Mirja Huhtinen, Piritta Koistinen, Lasse Leino, Maria Rantala, Helena Kaukinen, Kaija Af Ursin
  • HYDRODYNAMIC BEARING WITH ADAPTIVE DISPLACEMENT CONTROL
    Publication number: 20120063711
    Abstract: A hydrodynamic bearing includes a housing defining a central axis, a pad slidable relative to the housing in a direction substantially parallel to the central axis, a cylinder defined in one of the housing and the pad, a lubricant port in fluid communication with the cylinder, and a piston at least partially positioned in the cylinder. The piston is movable within the cylinder between a retracted position and an extended position in response to a flow of lubricant through the lubricant port to vary an axial spacing between the pad and the housing.
    Type: Application
    Filed: September 9, 2010
    Publication date: March 15, 2012
    Applicant: ORION CORPORATION
    Inventors: Thomas R. Byrne, Thomas H. Stietz
  • Method for the prevention of thromboembolic disorders
    Patent number: 8017609
    Abstract: A method for the prevention of thrombotic, embolic and/or hemorrhagic disorders, such as cerebral infarction (stroke) or myocardial infarction, by administering levosimendan or its metabolite (II) or any of their pharmaceutically acceptable salts to a mammal in need of such prevention.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: September 13, 2011
    Assignee: Orion Corporation
    Inventors: Heimo Haikala, Jouko Levijoki, Piero Pollesello, Carola Tilgmann
  • Process for manufacturing entacapone
    Patent number: 7932415
    Abstract: New processes for manufacturing entacapone are provided.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: April 26, 2011
    Assignee: Orion Corporation
    Inventors: Martti Hytönen, Leif Hilden
  • PHARMACEUTICAL COMPOUNDS
    Publication number: 20110086852
    Abstract: Compounds of formula (I), wherein R1-R4, X, Y and Z are as defined in claims, exhibit COMT enzyme inhibiting activity and are thus useful as COMT inhibitors.
    Type: Application
    Filed: July 17, 2006
    Publication date: April 14, 2011
    Applicant: Orion Corporation
    Inventors: Marko AHLMARK, Reijo BACKSTROM, Anne LUIRO, Jarmo PYSTYNEN, Eija TIAINEN
  • TRANSMUCOSAL VETERINARY COMPOSITION COMPRISING DETOMIDINE
    Publication number: 20110071203
    Abstract: The present invention relates to a veterinary composition in a semisolid form adapted for transmucosal administration for providing sedation and analgesia in large animals such as horses and cattle. The semisolid transmucosal composition of the invention comprises detomidine or a pharmaceutically acceptable salt thereof as an active ingredient. The composition provides a rapid onset of action while having low irritation potential in the oral mucosa.
    Type: Application
    Filed: November 24, 2010
    Publication date: March 24, 2011
    Applicant: Orion Corporation
    Inventors: Mirja Huhtinen, Piritta Koistinen, Lasse Leino, Maria Rantala, Helena Kaukinen, Kaija AF Ursin
  • Transmucosal veterinary composition comprising detomidine
    Patent number: 7863311
    Abstract: The present invention relates to a veterinary composition in a semisolid form adapted for transmucosal administration for providing sedation and analgesia in large animals such as horses and cattle. The semisolid transmucosal composition of the invention comprises detomidine or a pharmaceutically acceptable salt thereof as an active ingredient. The composition provides a rapid onset of action while having low irritation potential in the oral mucosa.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: January 4, 2011
    Assignee: Orion Corporation
    Inventors: Mirja Huhtinen, Piritta Koistinen, Lasse Leino, Maria Rantala, Helena Kaukinen, Kaija Af Ursin
  • Imidazole derivatives having affinity for alpha 2 receptors activity
    Patent number: 7759496
    Abstract: Novel prodrugs of MPV-2426, methods for preparing said prodrug forms, pharmaceutical compositions containing such prodrug forms, and methods for using the prodrug forms. A compound of general formula (I), or pharmaceutically acceptable salts or hydrates thereof, wherein R represents unsubstituted or substituted lower alkyl, unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted lower alkylamino or a saturated five or six membered heterocyclic group containing one or two nitrogen atoms.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: July 20, 2010
    Assignee: Orion Corporation
    Inventors: Tomi Järvinen, Riku Niemi, Juhani Huuskonen
  • Detomidine hydrochloride crystallization method
    Patent number: 7728147
    Abstract: A method of isolating detomidine (I) hydrochloride as a crystalline salt is provided. The method comprises hydrogenating in the presence of a catalyst of compound of formula (II) in aqueous solution comprising hydrochloric acid, concentrating the solution by distillation, optionally adding hydrochloric acid to the concentrated solution, cooling the concentrated solution and recovering the crystallized detomidine hydrochloride.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: June 1, 2010
    Assignee: Orion Corporation
    Inventors: Arto Karjalainen, Seppo Parhi
  • Atipamezole hydrochloride crystallization method
    Patent number: 7642279
    Abstract: A method of isolating atipamezole hydrocloride as a crystalline salt is provided.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: January 5, 2010
    Assignee: Orion Corporation
    Inventors: Seppo Parhi, Arto Karjalainen
  • Polycyclic compounds as potent alpha2-adrenoceptor antagonists
    Patent number: 7592350
    Abstract: A compound of formula I, wherein X, Z, R1 to R10, R15, R16, m, n, r and t are as defined in claim 1, or a pharmaceutically acceptable salt or ester thereof, useful as an alpha-2 antagonist. The compounds of formula I can be used for the treatment of diseases or conditions where antagonists of alpha-2 adrenoceptors are indicated to be effective.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: September 22, 2009
    Assignee: Orion Corporation
    Inventors: David Din Belle, Reija Jokela, Arto Tolvanen, Antti Haapalinna, Arto Karjalainen, Jukka Sallinen, Jari Ratilainen
  • Method for treating septic shock
    Patent number: 7485642
    Abstract: Levosimendan, or (?)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile, which has been mentioned for the treatment of congestive heart failure, is useful in the treatment of septic shock.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: February 3, 2009
    Assignee: Orion Corporation
    Inventors: Anders Oldner, Michael Wanecek, Eddie Weitzberg, Anders Rudehill
  • Pyridine derivatives useful for inhibiting sodium/calcium exchange system
    Patent number: 7482340
    Abstract: Therapeutically active compounds of formula (I) or (II): wherein the variables in formulas (I) and (II) are defined in the description, and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of Na+/Ca2+ exchange mechanism.
    Type: Grant
    Filed: January 9, 2004
    Date of Patent: January 27, 2009
    Assignee: Orion Corporation
    Inventors: Leena Otsomaa, Tuula Koskelainen, Arto Karjalainen, Sirpa Rasku, Piero Pollesello, Jouko Levijoki
  • Prolyl Oligopeptidase Inhibitors Ameliorating Recovery From Brain Trauma
    Publication number: 20080269313
    Abstract: The present invention relates to a method for the treatment of sensorimotor dysfunctions caused by brain trauma with an inhibitor of prolyl oligopeptidase or a pharmaceutically acceptable ester or salt thereof.
    Type: Application
    Filed: July 2, 2004
    Publication date: October 30, 2008
    Applicant: ORION CORPORATION
    Inventors: Jouni Sirvio, Tarja Lehtimaki
  • Compounds, which are potent inhibitors of Na /Ca exchange mechanism and are useful in the treatment of arrhythmias
    Patent number: 7425568
    Abstract: Therapeutically active compounds of formula (I): wherein the variables shown in formula (I) are defined in the disclosure; and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of the Na+/Ca2+ exchange mechanism.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: September 16, 2008
    Assignee: Orion Corporation
    Inventors: Tuula Koskelainen, Leena Otsomaa, Arto Karjalainen, Pekka Kotovuori, Jukka Tenhunen, Sirpa Rasku, Pentti Nore, Eija Tiainen, Olli Törmäkangas
  • Container for chewing gum
    Patent number: D577595
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: September 30, 2008
    Assignee: Orion Corporation
    Inventor: Hwa-Kyung Lee
  • Packaging box for confectionary
    Patent number: D637497
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: May 10, 2011
    Assignee: Orion Corporation
    Inventor: Hwa-Kyung Lee
  • Container for gum
    Patent number: D640138
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: June 21, 2011
    Assignee: Orion Corporation
    Inventor: Hwa-Kyung Lee
  • Container for gum
    Patent number: D640139
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: June 21, 2011
    Assignee: Orion Corporation
    Inventor: Hwa-Kyung Lee
  • Packaging sheet for confectionery
    Patent number: D661995
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: June 19, 2012
    Assignee: Orion Corporation
    Inventor: Hwa Kyoung Lee