Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.

Abstract: Compounds of formula I, wherein A, B, X, Z and R1-R6, are as defined in the claims, exhibit TRPA 1 activity and are thus useful as TRPA1 modulators.

Abstract: A cuvette adapted to contain spherical particles having a specific binding agent on the surface thereof and which have a detectably different light scattering characteristic in the presence of a material having a specific binding partner thereof, and which includes a window through which light can be projected for the purpose of determining any change in light scattering properties of the contents of the cuvette, and an optical element occupying at least part of a wall of the cuvette which, when light passes therethrough, causes at least some of the light to be deflected off axis towards a particular point. By using such a cuvette in combination with a light level detector located as the said particular point, a cuvette can be identified before an assay is performed by checking the light level at the said particular point. The optical element may be a halogram or a diffraction grating or a lens or any combination thereof.