Patents Assigned to Orquest, Inc.
  • Collagen-polysaccharide matrix for treatment of bone tumors
    Patent number: 6309670
    Abstract: A method of treatment for bone tumors comprising administering a matrix comprising collagen, a polysaccharide and a differentiation factor is provided. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent linkages to collagen.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: October 30, 2001
    Assignee: Orquest, Inc.
    Inventors: Mohammad Heidaran, Robert C. Spiro
  • Cross-linked polysaccharide drug carrier
    Patent number: 6303585
    Abstract: A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent oxime linkages with a second polysaccharide and each of the first and second polysaccharide is selected from the group consisting of hyaluronic acid, dextran, dextran sulfate, chondroitin sulfate, dermatan sulfate, keratan sulfate, heparan, heparan sulfate and alginate.
    Type: Grant
    Filed: July 1, 1998
    Date of Patent: October 16, 2001
    Assignee: Orquest, Inc.
    Inventors: Robert C. Spiro, Andrea Y. Thompson, LinShu Liu
  • Injectable hyaluronate-sulfated polysaccharide conjugates
    Patent number: 6288043
    Abstract: An injectable composition is provided for promoting bone and/or cartilage growth comprising hyaluronic acid cross-linked to sulfated polysaccharide through linking groups. The linking groups are diamines or amino polyalkylene glycols. The sulfated polysaccharide binds growth factors suitable for promoting tissue growth at the site of application of the composition.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: September 11, 2001
    Assignee: Orquest, Inc.
    Inventors: Robert C. Spiro, LinShu Liu
  • Method of promoting bone growth with hyaluronic acid and growth factors
    Publication number: 20010014664
    Abstract: A bone growth-promoting composition is provided comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at an intra-articular site of desired bone growth for a period of time sufficient to promote the bone growth. Preferably hyaluronic acid is used in a composition range of 0.1-4% by weight and preferred growth factor is bFGF, present in a concentration range of about 10−6 to 100 mg/ml.
    Type: Application
    Filed: April 3, 2001
    Publication date: August 16, 2001
    Applicant: Orquest, Inc., California Corporation
    Inventor: Michael Radomsky
  • Method of promoting bone growth with hyaluronic acid and growth factors
    Patent number: 6221854
    Abstract: A bone growth-promoting composition is provided comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at an intra-articular site of desired bone growth for a period of time sufficient to promote the bone growth. Preferably hyaluronic acid is used in a composition range of 0.1-4% by weight and preferred growth factor is bFGF, present in a concentration range of about 10−6 to 100 mg/ml.
    Type: Grant
    Filed: July 26, 1999
    Date of Patent: April 24, 2001
    Assignee: Orquest, Inc.
    Inventor: Michael Radomsky
  • Bone grafting matrix
    Patent number: 6187047
    Abstract: A porous three-dimensional bone grafting matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium phosphate immobilized in the matrix and having a particle size of 5 microns or less.
    Type: Grant
    Filed: July 7, 1998
    Date of Patent: February 13, 2001
    Assignee: Orquest, Inc.
    Inventors: Michael K. Kwan, Stephen D. Pacetti, Ronald K. Yamamoto
  • Collagen-polysaccharide matrix for bone and cartilage repair
    Patent number: 5972385
    Abstract: A matrix and a method for preparing it are provided to support the growth of tissue, such as bone, cartilage or soft tissue. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent linkages to collagen.
    Type: Grant
    Filed: January 15, 1998
    Date of Patent: October 26, 1999
    Assignee: Orquest, Inc.
    Inventors: LinShu Liu, Robert Spiro
  • Method of promoting bone growth with hyaluronic acid and growth factors
    Patent number: 5942499
    Abstract: A bone growth-promoting composition is provided comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at the site of desired bone growth for a period of time sufficient to promote the bone growth. Preferably hyaluronic acid is used in a composition range of 0.1-4% by weight and preferred growth factor is bFGF, present in a concentration range of about 10.sup.-6 to 100 mg/ml.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: August 24, 1999
    Assignee: Orquest, Inc.
    Inventor: Michael Radomsky
  • Collagen-polysaccharide matrix for bone and cartilage repair
    Patent number: 5866165
    Abstract: A matrix and a method for preparing it are provided to support the growth of bone or cartilage tissue. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent linkages to collagen.
    Type: Grant
    Filed: January 15, 1997
    Date of Patent: February 2, 1999
    Assignee: Orquest, Inc.
    Inventors: LinShu Liu, Robert C. Spiro
  • Bone grafting matrix
    Patent number: 5776193
    Abstract: A porous three-dimensional bone grafting matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium phosphate immobilized in the matrix and having a particle size of 5 microns or less.
    Type: Grant
    Filed: April 17, 1996
    Date of Patent: July 7, 1998
    Assignee: Orquest, Inc.
    Inventors: Michael K. Kwan, Stephen D. Pacetti, Ronald K. Yamamoto