Patents Assigned to Orsan
-
Patent number: 9345411Abstract: Devices, and methods for measuring bioimpedance signals are disclosed. One aspect may include a headset apparatus including a retainer and electrodes. The retainer may be configured to position the electrodes on the head of a subject so as to obtain bioimpedance signals indicative of hemodynamic conditions associated with an MCA territory. A processor may be included to measure and analyze the obtained bioimpedance signals, and to output information for predicting hemodynamic conditions associated with an MCA territory.Type: GrantFiled: October 3, 2011Date of Patent: May 24, 2016Assignee: Orsan Medical Technologies, Ltd.Inventors: Opher Kinrot, Michal Radai, Shlomi Ben-Ari
-
Patent number: 9307918Abstract: Devices, and methods for monitoring cerebro-hemodynamic signals are disclosed. In one aspect, the devices and methods may include receiving at least one signal characterizing a bioimpedance measurement. The at least one signal may be correlated with the timing of a cardiac wave and analyzed to ascertain an extent of an expected characteristic within the signal. The extent of the expected characteristic may be used to provide information for predicting a physiological brain condition. The at least one signal may include two signals, obtained from opposite brain hemispheres, and may be a bioimpedance signal.Type: GrantFiled: October 3, 2011Date of Patent: April 12, 2016Assignee: Orsan Medical Technologies Ltd.Inventors: Opher Kinrot, Shlomi Ben-Ari
-
Publication number: 20140163404Abstract: A method of estimating cerebral blood flow by analyzing IPG and PPG signals of the head, the method comprising: a) finding a maximum slope or most negative slope or the IPG signal, within at least a portion of the cardiac cycle; b) finding a maximum slope or most negative slope of the PPG signal, within at least a portion of the cardiac cycle; c) finding a ratio of the maximum or most negative slope of the IPG signal to the maximum or most negative slope of the PPG signal; and d) calculating a cerebral blood flow indicator from the ratio.Type: ApplicationFiled: July 15, 2013Publication date: June 12, 2014Applicant: Orsan Medical Technologies Ltd.Inventors: Yosef Reichman, Ben Zion Poupko, Shlomi Ben-Ari
-
Patent number: 8512253Abstract: A method of estimating cerebral blood flow by analyzing IPG and PPG signals of the head, the method comprising: a) finding a maximum slope or most negative slope or the IPG signal, within at least a portion of the cardiac cycle; b) finding a maximum slope or most negative slope of the PPG signal, within at least a portion of the cardiac cycle; c) finding a ratio of the maximum or most negative slope of the IPG signal to the maximum or most negative slope of the PPG signal; and d) calculating a cerebral blood flow indicator from the ratio.Type: GrantFiled: January 17, 2006Date of Patent: August 20, 2013Assignee: Orsan Medical Technologies, LtdInventors: Yosef Reichman, Ben Zion Poupko, Shlomi Ben-Ari
-
Patent number: 8211031Abstract: A method of estimating at least one intracranial hemodynamic parameter in a subject, the method comprising: a) obtaining data of changes in electrical impedance across the subject's head as a function of time; b) analyzing the data; and c) estimating one or more of intracranial pressure, cerebral blood volume, and a factor related to at least one of cerebral perfusion pressure and a mean transit time through cerebral capillaries.Type: GrantFiled: December 14, 2006Date of Patent: July 3, 2012Assignee: Orsan Medical Technologies Ltd.Inventors: Ben Zion Poupko, Yosef Reichman, Alon Rappaport, Shlomi Ben-Ari
-
Patent number: 8187197Abstract: A method of estimating cerebral blood flow includes obtaining a measure of time-varying blood volume in the head, using an impedance plethysmography (102 and 104), obtaining a measure of time-varying blood volume in the scalp, and using the time-varying blood volume in the head and scalp to estimate cerebral blood flow.Type: GrantFiled: June 15, 2005Date of Patent: May 29, 2012Assignee: Orsan Medical Technologies Ltd.Inventors: Aharon Shapira, Alon Rappaport, Shlomi Ben-Ari, Yosef Reichman, Ofer Barnea
-
Publication number: 20120022349Abstract: A method of evaluating patients suspected of suffering from an acute stroke, the method comprising: a) obtaining signals of impedance plethysmography (IPG), photoplethysmography (PPG) or both, in the patient; b) processing the one or more signals to obtain one or more measures of cerebral hemodynamics of the patient; and c) applying a rule to match said measures to a disease indication or choice of therapy or both, for the patient.Type: ApplicationFiled: October 7, 2009Publication date: January 26, 2012Applicant: Orsan Medical Technologies Ltd.Inventors: Ben Zion Poupko, Alon Rappaport, Shlomi Ben-Ari
-
Publication number: 20110251503Abstract: A method of estimating blood flow in the brain, comprising: a) causing currents to flow inside the head by producing electric fields inside the head; b) measuring at least changes in the electric fields and the currents; and c) estimating changes in the blood volume of the head, using the measurements of the electric fields and the currents.Type: ApplicationFiled: June 22, 2011Publication date: October 13, 2011Applicant: Orsan Medical Technologies Ltd.Inventors: Shlomi BEN-ARI, Alon Rappaport, Aharon Shapira
-
Publication number: 20110201950Abstract: A method of monitoring an acute stroke patient, comprising: a) obtaining signals of impedance plethysmography (IPG), photoplethysmography (PPG) or both, in the patient, at least once an hour, for at least six hours; b) processing the one or more signals to obtain one or more measures of cerebral hemodynamics of the patient; c) applying a rule about alerting or not alerting medical personnel based on any of values, amount of change, and direction and rate of change of the measures.Type: ApplicationFiled: October 7, 2009Publication date: August 18, 2011Applicant: Orsan Medical Technologies Ltd.Inventors: Ben Zion Poupko, Alon Rappaport, Shlomi Ben-Ari
-
Patent number: 7998080Abstract: A method of estimating blood flow in the brain, comprising: a) causing currents to flow inside the head by producing electric fields inside the head; b) measuring at least changes in the electric fields and the currents; and c) estimating changes in the blood volume of the head, using the measurements of the electric fields and the currents.Type: GrantFiled: July 15, 2004Date of Patent: August 16, 2011Assignee: Orsan Medical Technologies Ltd.Inventors: Shlomi Ben-Ari, Alon Rappaport, Aharon Shapira
-
Publication number: 20110196245Abstract: A method of finding an indication of a degree of cerebro-vascular bilateral asymmetry in a subject, comprising: a) measuring a first impedance waveform and a second impedance waveform of the subject's head as functions of time, in each case by finding a potential difference between two voltage electrodes associated with passing a given injected current through the head between at least two current electrodes, wherein in each case the voltage electrodes are located asymmetrically on the head, or the current is injected asymmetrically into the head, or both, and wherein the locations of the voltage electrodes and the distribution of current injection in measuring the second impedance waveform are minor images of what they are in measuring the first impedance waveform; and b) finding the indication of the degree of bilateral asymmetry from a difference between characteristics of the first and second impedance waveforms.Type: ApplicationFiled: October 7, 2009Publication date: August 11, 2011Applicant: Orsan Medical Technologies Ltd.Inventors: Ben Zion Poupko, Alon Rappaport, Shlomi Ben-Ari, Boaz Shpigelman
-
Publication number: 20090227881Abstract: A method of estimating cerebral blood flow by analyzing IPG and PPG signals of the head, the method comprising: a) finding a maximum slope or most negative slope or the IPG signal, within at least a portion of the cardiac cycle; b) finding a maximum slope or most negative slope of the PPG signal, within at least a portion of the cardiac cycle; c) finding a ratio of the maximum or most negative slope of the IPG signal to the maximum or most negative slope of the PPG signal; and d) calculating a cerebral blood flow indicator from the ratio.Type: ApplicationFiled: January 17, 2006Publication date: September 10, 2009Applicant: Orsan Medical Technologies Ltd.Inventors: Yosef Reichman, Ben Zion Poupko, Shlomi Ben-Ari
-
Publication number: 20080200787Abstract: A method of estimating blood flow in a brain, comprising: a) causing currents to flow inside the head by producing electric fields inside the head; b) measuring at least changes in the electric fields and the currents; c) estimating changes in the blood volume of the head, using the measurements of the electric fields and the currents, where the current are produced in children or using electrodes at or near holes in the skull. Optionally, the configuration is selected to focus the flow of current to be inside the brain to a significant degree.Type: ApplicationFiled: June 15, 2005Publication date: August 21, 2008Applicant: Orsan Medical Technologies Ltd.Inventors: Aharon Shapira, Alon Rappaport, Shlomi Ben-Ari
-
Publication number: 20070287899Abstract: A method of estimating at least one intracranial hemodynamic parameter in a subject, the method comprising: a) obtaining data of changes in electrical impedance across the subject's head as a function of time; b) analyzing the data; and c) estimating one or more of intracranial pressure, cerebral blood volume, and a factor related to at least one of cerebral perfusion pressure and a mean transit time through cerebral capillaries.Type: ApplicationFiled: December 14, 2006Publication date: December 13, 2007Applicant: Orsan Medical technologies Ltd.Inventors: Ben Poupko, Yosef Reichman, Alon Rappaport, Shlomi Ben-Ari
-
Publication number: 20050054939Abstract: A method of estimating blood flow in the brain, comprising: a) causing currents to flow inside the head by producing electric fields inside the head; b) measuring at least changes in the electric fields and the currents; and c) estimating changes in the blood volume of the head, using the measurements of the electric fields and the currents.Type: ApplicationFiled: July 15, 2004Publication date: March 10, 2005Applicant: Orsan Medical Equipment Ltd.Inventors: Shlomi Ben-Ari, Alon Rappaport, Aharon Shapira
-
Patent number: 6027920Abstract: A DNA cassette for expression and secretion of a given amino acid, polypeptide or protein in a host strain of corynebacterium, including a sequence which encodes the amino acid, polypeptide or protein, and a region of chromosomal or plasmid DNA, wherein the sequence is situated in the region of chromosomal or plasmid DNA such that the sequence is transcribed with, at the sequence's 5' end, at least one portion of a sequence encoding the signal sequence of the protein PS1 or PS2, the at least one portion ensuring the secretion of the amino acid, polypeptide or protein after translation when the DNA cassette is incorporated into the host strain of corynebacterium.Type: GrantFiled: July 31, 1995Date of Patent: February 22, 2000Assignee: OrsanInventors: Gwennael Joliff, Armel Guyonvarch, Purification Relano, Gerard Leblon, Francis Duchiron, Michel Renaud
-
Patent number: 5376537Abstract: A process for the production of cyclodextrins, comprising reacting non-treated starch with cyclodextrin-glycosyl-transferase produced by Bacillus ohbensis (FERM BP-3180), or produced by a mutant derived from Bacillus ohbensis (e.g., FERM BP-3180), or produced by any other strain in which the CGTase gene from B. ohbensis has been cloned, in an aqueous solution at pH between 6.5 and 8.8 and extracting the cyclodextrins from the reaction mixture by ultrafiltration, is provided.Type: GrantFiled: October 18, 1991Date of Patent: December 27, 1994Assignees: Orsan, Mercian CorporationInventors: Pierre H. Cami, Didier B. Majou
-
Patent number: 5304672Abstract: A method for the preparation of compounds of the formula ##STR1## wherein X represents a group of the formula OR.sub.1 or NR.sub.1 R.sub.2, wherein R.sub.1 and R.sub.2 independently represent H or an organic group that forms a stable covalent bond with the N or 0 of said X; Y is H or an organic group that forms a stable ester with the adjacent COO group; R is an alkyl or aryl group optionally substituted with one or more stable organic substituents; each R.sub.3 independently represents a stable organic group; and n is an integer from 0 to 3;the method using new intermediates of the formula ##STR2## wherein R.sub.3 and Y have the foregoing meanings;W is either F or Cl; andR.sub.9 is a hydrocarbon such as a C.sub.1 -C.sub.4 alkyl or alkenyl group.Type: GrantFiled: November 9, 1992Date of Patent: April 19, 1994Assignees: Orsan, OrsemInventors: Jeffrey Labovitz, William J. Guilford, Lawrence Fang, Yi Liang
-
Patent number: 5183891Abstract: A method for the preparation of compounds of the formula ##STR1## wherein X represents a group of the formula OR.sub.1 or NR.sub.1 R.sub.2, wherein R.sub.1 and R.sub.2 independently represent H or an organic group that forms a stable covalent bond with the N or O of said X; Y is H or an organic group that forms a stable ester with the adjacent COO group; R is an alkyl or aryl group optionally substituted with one or more stable organic substituents; each R.sub.3 independently represents a stable organic group; and n is an integer from 0 to 3;the method using new intermediates of the formula ##STR2## wherein R.sub.3 and Y have the foregoing meanings; W is either F or Cl;and R.sub.9 is a hydrocarbon such as a C.sub.1 -C.sub.4 alkyl or alkenyl group.Type: GrantFiled: November 9, 1989Date of Patent: February 2, 1993Assignees: Orsan, OrsemInventors: Jeffrey Labovitz, William J. Guilford, Lawrence Fang, Yi Liang
-
Patent number: 5129940Abstract: Pollen is suppressed in Liliopsida by use of compounds of the formula ##STR1## wherein X represents a group of the formula OR.sup.1 wherein R.sup.1 represents a C.sub.1 -C.sub.4 alkyl optionally substituted with a C.sub.1 -C.sub.4 alkoxy group; or C.sub.2 -C.sub.4 and R represents phenyl or phenyl substituted with one to three halogen atoms or C.sub.1 -4 haloalkoxy; or an agriculturally acceptable salt thereof are disclosed along with methods to produce hybrid seed in self-fertilizing plants.Type: GrantFiled: August 22, 1991Date of Patent: July 14, 1992Assignee: OrsanInventor: Thomas G. Patterson