Patents Assigned to Ortho-Clinical
  • Antibodies to quetiapine and use thereof
    Patent number: 9410972
    Abstract: Disclosed is an antibody which binds to quetiapine, which can be used to detect quetiapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of quetiapine, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a single lateral flow assay device.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: August 9, 2016
    Assignees: Janssen Pharmaceutica NV, Ortho-Clinical Diagnostics, Inc.
    Inventors: Eric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Bart M. Remmerie, Rhys Salter, Matthew Garrett Donahue, Yong Gong
  • Haptens of paliperidone
    Patent number: 9394354
    Abstract: The invention relates to compounds of Formula I, wherein L1, L2, and L3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from paliperidone. The invention also relates to conjugates of a paliperidone hapten and a protein.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: July 19, 2016
    Assignees: Janssen Pharmaceutica NV, Ortho-Clinical Diagnostics, Inc.
    Inventors: Pieter Rik Haspeslagh, Maarten Vliegen, Eric Hryhorenko, Thomas R. DeCory, Banumathi Sankaran
  • GLASS BEAD FLOW RATES TO FACILITATE IMMUNODIAGNOSTIC TEST ELEMENT MANUFACTURE
    Publication number: 20160202255
    Abstract: A method of preparing a glass bead mixture using inert nanoparticles to improve flow rates of the glass beads for purposes of manufacturing an immunodiagnostic test element, such as a column agglutination test cassette, and a test element made in accordance with the method.
    Type: Application
    Filed: March 23, 2016
    Publication date: July 14, 2016
    Applicant: Ortho-Clinical Diagnostics, Inc.
    Inventors: Jonathan Burr Crowther, Amy Louise Surowitz, Anna Krystyna Luczak
  • Lateral flow assay devices for use in clinical diagnostic apparatus and configuration of clinical diagnostic apparatus for same
    Patent number: 9389228
    Abstract: A lateral flow device for use in a mainframe or point-of-care clinical analyzer, in which the lateral flow device includes a planar support having at least one sample addition area and at least one reaction area disposed thereon. The sample addition area and reaction area are fluidly interconnected to one another and form at least one lateral fluid flow path. The lateral flow device is sized for retention within a storage cartridge of the analyzer defined by a hollow interior and having a plurality of lateral flow assay devices retained in stacked relation therein.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: July 12, 2016
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Raymond F. Jakubowicz, Randy K. Bower, Joseph J. Dambra, Zhong Ding, James E. Robinson, Dale R. Ryan, David A. Tomasso
  • Detection method and determination method for detection target
    Patent number: 9372187
    Abstract: A detection/determination kit with which a substance to be detected or the amount thereof can be rapidly, inexpensively, and easily detected or determined; and a detection/determination method. The kit, which is for detecting a substance to be detected (50) contained in a specimen, comprises: a first compound (10) comprising a first substance including a stimulus-responsive polymer (11) and, bonded to the first substance, a first antibody (13) against the substance (50); and a second compound (20) comprising a second substance (21) which is hydrophilic and, bonded thereto, a second antibody (23) against the substance (50). The first antibody (13) and second antibody (23) can simultaneously combine with the substance (50) at different sites in the substance (50).
    Type: Grant
    Filed: December 25, 2008
    Date of Patent: June 21, 2016
    Assignees: ORTHO-CLINICAL DIAGNOSTICS KABUSHIKI KAISHA, JNC CORPORATION
    Inventors: Toshiya Sawai, Eri Oowada, Yasunobu Sato, Hirokazu Nagaoka, Satoru Sugita
  • Glass bead flow rates to facilitate immunodiagnostic test element manufacture
    Patent number: 9354242
    Abstract: A method of preparing a glass bead mixture using inert nanoparticles to improve flow rates of the glass beads for purposes of manufacturing an immunodiagnostic test element, such as a column agglutination test cassette, and a test element made in accordance with the method.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: May 31, 2016
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Johnathan Burr Crowther, Amy Louise Surowitz, Anna Krystyna Luczak
  • Apparatus for gripping and holding diagnostic cassettes
    Patent number: 9335337
    Abstract: The apparatus is a mechanism for acquiring, holding, and enabling the movement of a cassette-shaped article, such as a reagent or sample cassette, which may be part of an automated diagnostic analyzer, such that the apparatus can tolerate a significant degree of cassette misplacement and/or misalignment during the acquisition maneuver. The mechanism furthermore enables simultaneous two-dimensional movement of the acquiring gripper jaws such that the inter-jaw distance decreases at the same time as movement in an upward vertical direction is provided while the jaw movement is adequately smooth so as not to disturb the physical state of the sample.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: May 10, 2016
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Robert S. Jones, Lynn J. Willett
  • Treponema Pallidum Triplet Antigen
    Publication number: 20160115206
    Abstract: A Treponema pallidum triplet antigen construct is disclosed which includes three Treponema pallidum antigens (TP15, TP17, and TP47), as well as a ten amino acid leader sequence (tag 261) and human copper zinc superoxide dismutase (hSOD). This construct is optimized for in vitro diagnosis of syphilis infection. Plasmids containing DNA encoding the triplet antigen, host cells, production methods, detection methods, and kits are also disclosed.
    Type: Application
    Filed: December 28, 2015
    Publication date: April 28, 2016
    Applicant: Ortho-Clinical Diagnostics, Inc.
    Inventors: Jian Zheng, Renee Yura, Jianping Yang
  • Reagents For HCV Antigen-Antibody Combination Assays
    Publication number: 20160109447
    Abstract: The present invention is directed to combination immunoassays, reagents and kits for simultaneous detection of HCV antigens and anti-HCV antibodies in a sample. The combination immunoassays of the present invention employ a non-ionic detergent that effectively exposes or releases the HCV core antigen from virions in a sample without interfering with the performance of other reagents such as the capture of anti-HCV antibodies by recombinant HCV antigens.
    Type: Application
    Filed: December 29, 2015
    Publication date: April 21, 2016
    Applicant: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Jian Zheng, Jianping Yang
  • Patient sample classification based upon low angle light scattering
    Patent number: 9310286
    Abstract: An apparatus for classifying a liquid patient sample includes at least one sample container having a quantity of a sample that is aggressively acted upon so as to create a flow field. A measurement mechanism includes at least one low angle light emitter aligned with a measurement window of the at least one sample container and a detector oppositely disposed relative to the measurement window. Measurement of the scattered light detects particle characteristics of a moving flow field from the sample to determine, for example, the amount of agglutination of the sample so as to perform blood typing or other classifications without spatial separation.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: April 12, 2016
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Merrit N. Jacobs, Michael W. Sundberg, Zhong Ding
  • Haptens of olanzapine
    Patent number: 9303041
    Abstract: The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from olanzapine. The invention also relates to conjugates of an olanzapine hapten and a protein.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: April 5, 2016
    Assignees: Janssen Pharmaceutica NV, Ortho-Clinical Diagnostics, Inc.
    Inventors: Matthew Garrett Donahue, Yong Gong, Rhys Salter, Eric Hryhorenko, Thomas R. DeCory, Bart Remmerie, Banumathi Sankaran
  • Haptens of quetiapine
    Patent number: 9304126
    Abstract: The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from quetiapine. The invention also relates to conjugates of a quetiapine hapten and a protein.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: April 5, 2016
    Assignees: Janssen Pharmaceutica NV, Ortho-Clinical Diagnostics, Inc.
    Inventors: Matthew Garrett Donahue, Yong Gong, Rhys Salter, Eric Hryhorenko, Thomas R. DeCory, Bart Remmerie, Banumathi Sankaran
  • Treponema pallidum triplet antigen
    Patent number: 9221884
    Abstract: A Treponema pallidum triplet antigen construct is disclosed which includes three Treponema pallidum antigens (TP15, TP17, and TP47), as well as a ten amino acid leader sequence (tag 261) and human copper zinc superoxide dismutase (hSOD). This construct is optimized for in vitro diagnosis of syphilis infection. Plasmids containing DNA encoding the triplet antigen, host cells, production methods, detection methods, and kits are also disclosed.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: December 29, 2015
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Jian Zheng, Renee Yura, Jianping Yang
  • Determination of sFlt-1:angiogenic factor complex
    Patent number: 9128099
    Abstract: Methods for determining the presence or amount of a complex comprising a first and second molecular entity are provided, preferably an sFlt-1:PlGF complex. A determination of the presence or amount of the complex can be used in methods for predicting, detecting, monitoring a disease, or guiding therapy in respect to a disease such as vascular, vascular-related disease, cardiac, cardiac-related disease, cancer, cancer-related disease, preeclampsia, and preeclampsia-related disease. Determining sFlt-1:angiogenic factor complex is particularly useful for predicting and detecting preeclampsia in early stages of gestation and in stages of the disease where clinical evaluation may be uninformative.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: September 8, 2015
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: George Bashirians, Deborah Byrne, Sarah Groulx, Sharon Jackson, Heather Lane-Brown, Banumathi Sankaran, Edward Scalice, Karen Yang, Jian Zheng
  • Apparatus for gripping and holding diagnostic cassettes
    Patent number: 9075031
    Abstract: The apparatus is a mechanism for acquiring, holding, and enabling the movement of a cassette-shaped article, such as a reagent or sample cassette, which may be part of an automated diagnostic analyzer, such that the apparatus can tolerate a significant degree of cassette misplacement and/or misalignment during the acquisition maneuver. The mechanism furthermore enables simultaneous two-dimensional movement of the acquiring gripper jaws such that the inter-jaw distance decreases at the same time as movement in an upward vertical direction is provided while the jaw movement is adequately smooth so as not to disturb the physical state of the sample.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: July 7, 2015
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Robert S. Jones, Lynn J. Willett
  • Full resolution color imaging of an object
    Patent number: 9066021
    Abstract: The invention relates generally to both a method and apparatus for the creation of full resolution color digital images of diagnostic cassettes or objects of interest using a gray-scale digital camera or sensor combined with time sequential illumination using additive primary colors followed by post exposure digital processing. Such procedures and equipment is of significant economic value when employed in situations such as diagnostic clinical analyzers where space is limited and image quality requirements are high.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: June 23, 2015
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Jens H. Jorgensen, Michael W. LaCourt, Donald J. Moran, Jr., David J. Hawks, Joseph Wycallis, Stephen C. Arnold
  • Detection method and quantification method for target substance
    Patent number: 9063144
    Abstract: Provided are a detection method and a quantification method for a detection target, which can detect and quantify the detection target rapidly, inexpensively, simply, and with high accuracy in a variety of environments.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: June 23, 2015
    Assignees: JNC Corporation, Ortho-Clinical Diagnostics Kabushiki Kaisha
    Inventors: Katsuhiko Kitsugi, Satoru Sugita, Noriyuki Ohnishi
  • Single column immunological test elements
    Patent number: 9052297
    Abstract: A plurality of individual single column test elements are provided for use in a clinical testing apparatus. Each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover strip used to access the contents of the test column. Individual test elements can be stored, retained and dispensed for testing patient samples.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: June 9, 2015
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Raymond F. Jakubowicz, Mark Sawczuk
  • Event-based communication in a clinical diagnostic analyzer
    Patent number: 8959200
    Abstract: A networked clinical diagnostic analyzer is disclosed with support for monitoring by a remote back office. The disclosed analyzer includes a module to detect in real-time events of interest while allowing the back office to modify the definitions of the events. The module may be networked using virtual private networking into the back office network, which is usually different from the network at the site of the clinical diagnostic analyzer's deployment. The real-time alerts allow both a quick response to actual or expected error conditions and the downloading of logged data that is likely of most interest and relevance.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: February 17, 2015
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Trevor Gyles, Keith Arnold Baker, Richard Peter Hemmenway, Christopher Thomas Doody
  • Calibrator/control for simultaneous assay of proteins capable of complexing with one another
    Patent number: 8940492
    Abstract: Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such compositions are useful as reference, calibrators or controls in methods and assays for determining the amount of one or more of the proteins that may be present in a sample of interest or in confirming the presence of one or more of the proteins in the sample. More particularly, it relates to compositions and methods comprising altered placental growth factor-1 (PlGF-1) and soluble fms-like tyrosine kinase (sFlt-1) and methods for determining the amount or confirming the presence of sFlt-1 and/or PlGF-1 in a sample of interest.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: January 27, 2015
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: John W. Backus, Jian Zheng, George Bashirians