Abstract: A transgenic animal with alterations in an IRAK gene is prepared by introduction of an altered IRAK gene into a host animal. The resulting transgenic animals do not produce functional IRAK molecules. Cells and cell lines derived from these animals also contain the altered IRAK gene.
Type:
Grant
Filed:
May 13, 1999
Date of Patent:
December 26, 2000
Assignee:
Ortho-McNeil Pharmacueticals
Inventors:
Crafford A. Harris, John J. Siekierka, Per A. Peterson, Wai-Ping Leung