Abstract: Disclosed are methods of forming an antimicrobial and/or antiviral metal coating on a substrate comprising surface groups that bond to a metal alkoxide to form a 3-dimensional metal oxide/alkoxide adhesion layer. The methods include A) soaking or spraying a substrate comprising a 3-dimensional metal oxide/alkoxide layer with a solution of a transition metal salt, and reduction of the transition metal salt to form a continuous network of transition metal within the 3-D layer, or B) soaking or spraying a substrate comprising a 3-dimensional metal oxide/alkoxide layer with a solution of a post-transition metal salt, sintering at high temperature to form a continuous post-transition metal network within the 3-D layer, and electrolyzing to replace post-transition metal with a transition metal.
Type:
Application
Filed:
September 28, 2021
Publication date:
September 14, 2023
Applicants:
THE TRUSTEES OF PRINCETON UNIVERSITY, ORTHOBOND CORPORATION
Inventors:
Jeffrey Schwartz, Carlos E. Caicedo-Carvajal, Gregorg E. Lutz, Siyang Yang
Abstract: Articles having functional surfaces, for example antimicrobial functional surfaces, are prepared by methods comprising anodization. Organophosphorous compounds are deposited on a surface by methods comprising anodization, followed by attaching functional compounds, functional oligomers or functional polymers. Alternatively, functional organophosphorous compounds, functional oligomers or functional polymers are deposited on a surface by methods comprising anodization.
Abstract: Disclosed are novel compositions and methods for making a polymer substrate and a ligand that includes a proximal portion with a photoactive compound bound to the polymer substrate, a terminal portion with an anti-infective/anti-microbial compound, and a reactive portion attaching the proximal portion and the terminal portion.
Type:
Grant
Filed:
January 22, 2018
Date of Patent:
April 21, 2020
Assignee:
Orthobond Corporation
Inventors:
Randy Clevenger, Se-Ho Kim, Jordan Katz, Carlos Caicedo-Carvajal
Abstract: Devices are provided which are functionalized to include surface regions having anti-infective agents. Methods are provided for functionalizing various material surfaces to include active surface regions for binding anti-infective agents. Methods are provided by which anti-infective moieties or agents are bonded to functionalized surfaces.
Type:
Grant
Filed:
April 26, 2017
Date of Patent:
March 24, 2020
Assignees:
Orthobond Corporation, The Trustees of Princeton University
Inventors:
Randell Clevenger, Thomas J. Dennes, Jeffrey Schwartz
Abstract: Disclosed in certain embodiments is a composition comprising a biological material and transition metal atoms selected from the group consisting of Group IVB, Group VB, Group VIB of the Periodic Chart and a combination thereof, bound to a surface of the biological material.
Type:
Grant
Filed:
February 3, 2017
Date of Patent:
November 12, 2019
Assignee:
Orthobond Corporation
Inventors:
Randell Clevenger, Rong Dong, Jordan Katz
Abstract: Disclosed in certain embodiments is a composition comprising a first material; an adhesive material attached to the first material; a plurality of linker molecules bonded to the adhesive material; and a second material bonded to the linker molecules.
Type:
Grant
Filed:
January 7, 2015
Date of Patent:
October 22, 2019
Assignee:
Orthobond Corporation
Inventors:
Carlos Caicedo-Carvajal, Randy Clevenger, Sam Hong, Jordan Katz, Cheoljin Kim
Abstract: Articles having metal, metalloid or non-metal surfaces containing an antimicrobial layer comprising antimicrobial oligomers or polymers are suitable for use in medical devices, sanitary surfaces and other applications. Antimicrobial layers contain an organophosphorus layer deposited on an article surface and antimicrobial oligomers or polymers bonded to the organophosphorus layer.