Patents Assigned to Orthogen AG
  • Patent number: 11896972
    Abstract: The invention relates to an apparatus for receiving a body fluid, wherein the apparatus comprises a first chamber with a displaceable wall and a second chamber of a constant effective size, said second chamber being movable with respect to the displaceable wall, wherein the apparatus is designed to connect the first chamber and the second chamber during a longitudinally axial movement of the second chamber with respect to the displaceable wall and to transfer body fluid from the first chamber to the second chamber during a movement of the second chamber together with the displaceable wall.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: February 13, 2024
    Assignee: ORTHOGEN AG
    Inventors: Nina Breidenbach, Julio Reinecke, Julien Troillet, Peter Wehling, Julia Heindirk
  • Patent number: 11819841
    Abstract: The invention relates to an apparatus for receiving a body fluid, wherein the apparatus comprises a first chamber with a displaceable wall and a second chamber of a constant effective size, said second chamber being movable with respect to the displaceable wall, wherein the apparatus is designed to connect the first chamber and the second chamber during a longitudinally axial movement of the second chamber with respect to the displaceable wall and to transfer body fluid from the first chamber to the second chamber during a movement of the second chamber together with the displaceable wall.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: November 21, 2023
    Assignee: ORTHOGEN AG
    Inventors: Nina Breidenbach, Julio Reinecke, Julien Troillet, Peter Wehling, Julia Heindirk
  • Publication number: 20210290671
    Abstract: The present invention relates a pharmaceutical preparation for use in the treatment of ageing or as an anti-ageing agent, which is preparable by a production method comprising the following steps: providing a liquid collected from an organism, which liquid comprises cellular constituents of blood, and a vessel or containment means and contacting said liquid with said vessel or containment means, wherein (i) said production method further comprises the step of incubating said liquid in said Vessel or containment means, and optionally removing cellular constituents of said liquid after said incubation, (ii) said liquid comprises exosomes, and said production method further comprises the steps of concentrating said exosomes and optionally removing cellular constituents of said liquid after said concentration, or the step of isolating said exosomes, or (iii) said production method further comprises the step of avoiding incubation of said liquid, and the step of removing cellular constituents of said liquid con
    Type: Application
    Filed: May 12, 2017
    Publication date: September 23, 2021
    Applicant: ORTHOGEN AG
    Inventors: Peter WEHLING, Julio REINECKE
  • Publication number: 20210260110
    Abstract: The invention relates a method for producing a pharmaceutical composition, comprising the steps of: providing a liquid collected from a mammal, which liquid comprises cellular constituents of blood, providing a container having an internal surface, contacting said liquid with said internal surface, incubating said liquid contacted with said internal surface for an incubation time, wherein said liquid is agitated with an agitation means at least once during said incubation time, and after said incubation time has passed, obtaining said pharmaceutical composition by steps comprising (1) collecting said liquid or (2) removing part of or the entirety of said cellular constituents from said liquid and collecting the remainder.
    Type: Application
    Filed: August 22, 2019
    Publication date: August 26, 2021
    Applicant: ORTHOGEN AG
    Inventors: Peter WEHLING, Julio REINECKE, Julia HEINDIRK
  • Publication number: 20200238274
    Abstract: The invention relates to an apparatus for receiving a body fluid, wherein the apparatus comprises a first chamber with a displaceable wall and a second chamber of a constant effective size, said second chamber being movable with respect to the displaceable wall, wherein the apparatus is designed to connect the first chamber and the second chamber during a longitudinally axial movement of the second chamber with respect to the displaceable wall and to transfer body fluid from the first chamber to the second chamber during a movement of the second chamber together with the displaceable wall.
    Type: Application
    Filed: October 10, 2018
    Publication date: July 30, 2020
    Applicant: ORTHOGEN AG
    Inventors: Nina BREIDENBACH, Julio REINECKE, Julien TROILLET, Peter WEHLING, Julia HEINDIRK
  • Publication number: 20200206396
    Abstract: The invention concerns a device for the transfusion of body fluid, comprising a chamber for accommodating the body fluid, wherein the chamber has a cylindrical section and narrows in its end region, wherein the inclination of the wall in the end region of the chamber is continuous along the longitudinal axis.
    Type: Application
    Filed: September 14, 2018
    Publication date: July 2, 2020
    Applicant: ORTHOGEN AG
    Inventors: Julien TROILLET, Julio REINECKE, Peter WEHLING
  • Patent number: 10537614
    Abstract: The present invention relates to pharmaceutical compositions for a combination therapy with a corticosteroid and exosomes. By means of the combination therapy diseases such as osteoarthritis, arthritis and/or degenerative spinal diseases can be treated.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: January 21, 2020
    Assignee: ORTHOGEN AG
    Inventors: Peter Wehling, Julio Reinecke
  • Publication number: 20190290689
    Abstract: The present invention provides a pharmaceutical preparation for use by injection into the skin, wherein the pharmaceutical preparation is preparable by a production method comprising the steps of providing a liquid collected from an organism, which liquid comprises cellular constituents of blood, providing a vessel or containment means, said vessel or containment means having an internal surface, and contacting said liquid with said vessel or containment means, wherein (a) said production method further comprises the step of incubating said liquid in said vessel or containment means for an incubation time, and optionally removing cellular constituents of said liquid after said incubation, (b) said liquid comprises exosomes, and said production method further comprises the steps of concentrating said exosomes and optionally removing cellular constituents of said liquid after said concentration, or the step of isolating said exosomes, or (c) said production method further comprises the step of avoiding incubat
    Type: Application
    Filed: May 11, 2017
    Publication date: September 26, 2019
    Applicant: ORTHOGEN AG
    Inventors: Peter WEHLING, Julio REINECKE
  • Publication number: 20190231816
    Abstract: The present invention provides a pharmaceutical preparation and in particular a combination of a pharmaceutical preparation and hyaluronic acid for use as a medicament, wherein the pharmaceutical preparation is injected into an intact skin and is preparable by a production method comprising the steps of providing a liquid collected from an organism, which liquid comprises cellular constituents of blood, providing a vessel or containment means, said vessel or containment means having an internal surface, and contacting said liquid with said vessel or containment means, wherein (a) said production method further comprises the step of incubating said liquid in said vessel or containment means for an incubation time, and optionally removing cellular constituents of said liquid after said incubation, or (b) said liquid comprises exosomes, and said production method further comprises the steps of concentrating said exosomes and optionally removing cellular constituents of said liquid after said concentration, or t
    Type: Application
    Filed: August 17, 2017
    Publication date: August 1, 2019
    Applicant: ORTHOGEN AG
    Inventors: Peter WEHLING, Julio REINECKE
  • Publication number: 20190192579
    Abstract: The present invention relates to a combination of a blood preparation and a helminthic preparation for use as a medicament, wherein the blood preparation is preparable by a production method comprising the following steps: providing a blood sample collected from an organism and a vessel or container, contacting said blood sample with said vessel or a container, and incubating said blood sample in said vessel or container, wherein said blood sample is (1) a whole blood sample or (2) a whole blood sample from which certain or all cells have been depleted. Moreover, the present invention relates to the non-therapeutic use of a blood preparation in combination with a helminthic preparation, wherein the helminthic preparation comprises helminths which are incapable of reproducing in the organism and/or which do not infect the organism and particularly do not chronically infect the organism, and wherein the blood preparation is preparable by a production method as described above.
    Type: Application
    Filed: August 25, 2017
    Publication date: June 27, 2019
    Applicant: ORTHOGEN AG
    Inventors: Peter WEHLING, Julio REINECKE
  • Publication number: 20190038719
    Abstract: The present invention relates to pharmaceutical compositions for a combination therapy with a corticosteroid and exosomes. By means of the combination therapy diseases such as osteoarthritis, arthritis and/or degenerative spinal diseases can be treated.
    Type: Application
    Filed: June 12, 2017
    Publication date: February 7, 2019
    Applicant: ORTHOGEN AG
    Inventors: PETER WEHLING, JULIO REINECKE
  • Patent number: 10111905
    Abstract: The present invention refers to a pharmaceutical preparation for use as an antibacterial agent, where the pharmaceutical preparation is prepared by a method comprising the steps of bringing a full blood sample taken from a patient in contact with a vessel or container and incubating the sample.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: October 30, 2018
    Assignee: ORTHOGEN AG
    Inventors: Maria-Paz Weisshaar, Julio Reinecke, Peter Wehling
  • Patent number: 9724391
    Abstract: The present invention relates to pharmaceutical compositions for a combination therapy with a corticosteroid and exosomes. By means of the combination therapy diseases such as osteoarthritis, arthritis and/or degenerative spinal diseases can be treated.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: August 8, 2017
    Assignee: ORTHOGEN AG
    Inventors: Peter Wehling, Julio Reinecke
  • Patent number: 8828946
    Abstract: The present invention relates to pharmaceutical compositions for a combination therapy with a cytokine antagonist and a corticosteroid. By means of the combination therapy diseases such as osteoarthritis, tendon injuries and/or degenerative spinal diseases can be treated.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: September 9, 2014
    Assignee: Orthogen AG
    Inventors: Peter Wehling, Julio Reinecke
  • Publication number: 20140093545
    Abstract: The present invention refers to a pharmaceutical preparation for use as an antibacterial agent, where the pharmaceutical preparation is prepared by a method comprising the steps of bringing a full blood sample taken from a patient in contact with a vessel or container and incubating the sample.
    Type: Application
    Filed: September 26, 2013
    Publication date: April 3, 2014
    Applicant: ORTHOGEN AG
    Inventors: Maria-Paz Weisshaar, Julio Reinecke, Peter Wehling
  • Publication number: 20130164303
    Abstract: The present invention relates to pharmaceutical compositions for a combination therapy with a cytokine antagonist and a corticosteroid. By means of the combination therapy diseases such as osteoarthritis, tendon injuries and/or degenerative spinal diseases can be treated.
    Type: Application
    Filed: November 7, 2011
    Publication date: June 27, 2013
    Applicant: Orthogen AG
    Inventors: Peter Wehling, Julio Reinecke
  • Publication number: 20120237587
    Abstract: The present invention relates to pharmaceutical compositions for a combination therapy with a corticosteroid and exosomes. By means of the combination therapy diseases such as osteoarthritis, arthritis and/or degenerative spinal diseases can be treated.
    Type: Application
    Filed: December 10, 2010
    Publication date: September 20, 2012
    Applicant: ORTHOGEN AG
    Inventors: Peter Wehling, Julio Reinecke
  • Publication number: 20120237525
    Abstract: The present invention relates to pharmaceutical compositions for a combination therapy with a cytokine antagonist and a corticosteroid. By means of the combination therapy diseases such as osteoarthritis, tendon injuries and/or degenerative spinal diseases can be treated.
    Type: Application
    Filed: December 10, 2010
    Publication date: September 20, 2012
    Applicant: ORTHOGEN AG
    Inventors: Peter Wehling, Julio Reinecke
  • Patent number: 6759188
    Abstract: The present invention relates to a method for producing a prophylactically or therapeutically active protein, the syringe being filled with a body fluid and incubated, and the prophylactically or therapeutically active protein subsequently being formed in the body fluid.
    Type: Grant
    Filed: December 31, 2002
    Date of Patent: July 6, 2004
    Assignee: Orthogen AG
    Inventors: Julio Reinecke, Hans Meijer, Peter Wehling
  • Patent number: 6713246
    Abstract: The present invention relates to a method for producing interleukin-1 receptor antagonists, a prophylatically or therapeutically effective protein. A syringe is filled with a body fluid and incubated. The prophylatically or therapeutically effective protein is then produced in the body fluid.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: March 30, 2004
    Assignee: Orthogen AG
    Inventors: Julio Reinecke, Hans Meijer, Peter Wehling