Abstract: A bone biospecific agent comprises a contrast material core, which is visible using Magnetic Resonance Imaging (MRI) or Computed Tomography (CT). The contrast material core is surrounded by a polymeric shell, which is functionalised with a bone-targeting peptide. In use, the peptide targets the biospecific agent to bone. The bone biospecific agent can be used in diagnostic imaging techniques, such as MRI and CT, and in imaging bone remodelling activities, detecting and treating pathological bone conditions and/or bone repair processes. The invention extends to the diagnosis and/or treatment of bone disease and bone pathologies using the biospecific agents.
Type:
Grant
Filed:
November 25, 2019
Date of Patent:
October 11, 2022
Assignee:
ORTHOPAEDIC RESEARCH UK
Inventors:
Matteo Santin, Steven Thomas Meikle, Lubinda Mbundi
Abstract: A bone biospecific agent comprises a contrast material core, which is visible using Magnetic Resonance Imaging (MRI) or Computed Tomography (CT). The contrast material core is surrounded by a polymeric shell, which is functionalised with a bone-targeting peptide. In use, the peptide targets the biospecific agent to bone. The bone biospecific agent can be used in diagnostic imaging techniques, such as MRI and CT, and in imaging bone remodelling activities, detecting and treating pathological bone conditions and/or bone repair processes. The invention extends to the diagnosis and/or treatment of bone disease and bone pathologies using the biospecific agents.
Type:
Application
Filed:
November 25, 2019
Publication date:
July 9, 2020
Applicant:
ORTHOPAEDIC RESEARCH UK
Inventors:
Matteo Santin, Steven Thomas Meikle, Lubinda Mbundi
Abstract: A bone biospecific agent comprises a contrast material core, which is visible using Magnetic Resonance Imaging (MRI) or Computed Tomography (CT). The contrast material core is surrounded by a polymeric shell, which is functionalised with a bone-targeting peptide. In use, the peptide targets the biospecific agent to bone. The bone biospecific agent can be used in diagnostic imaging techniques, such as MRI and CT, and in imaging bone remodelling activities, detecting and treating pathological bone conditions and/or bone repair processes. The invention extends to the diagnosis and/or treatment of bone disease and bone pathologies using the biospecific agents.
Type:
Application
Filed:
January 31, 2014
Publication date:
December 24, 2015
Applicant:
ORTHOPAEDIC RESEARCH UK
Inventors:
Matteo Santin, Steven Thomas Meikle, Lubinda Mbundi