Patents Assigned to OrthoTrophix, Inc.
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Patent number: 11963996Abstract: Knee pain caused by osteoarthritis is relieved by modifying the shape change of bone(s) underlying articular cartilage, by a method comprising evaluating the bone shape of the patient's joint, injecting the patient with a peptide of SEQ ID No. 1 or applying other therapeutic interventions that can reduce the shape change of the bone(s) underlying articular cartilage, and thereafter evaluating the bone shape of the patient's joint.Type: GrantFiled: September 27, 2019Date of Patent: April 23, 2024Assignee: ORTHOTROPHIX, Inc.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Publication number: 20230414705Abstract: Compounds, pharmaceutical compositions, and a method of treating hard tissue diseases and disorders are disclosed. The compounds may be a peptide and is structured to bind integrin ?v?3 expressed by osteocytes and by selective binding to the cell surface integrin on hard tissue forming cells regulate three-dimensional bone shape, cartilage formation and repair.Type: ApplicationFiled: September 5, 2023Publication date: December 28, 2023Applicant: OrthoTrophix, Inc.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Patent number: 11793857Abstract: Compounds, pharmaceutical compositions, and a method of treating hard tissue diseases and disorders are disclosed. The compounds may be a peptide and is structured to bind integrin ?v?3 expressed by osteocytes and by selective binding to the cell surface integrin on hard tissue forming cells regulate three-dimensional bone shape, cartilage formation and repair.Type: GrantFiled: September 17, 2021Date of Patent: October 24, 2023Assignee: ORTHOTROPHIX, INC.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Patent number: 11413327Abstract: A method of alleviating joint pain in a patient comprising evaluating the patient's joint pain when undergoing motions associated stress to the joint, and injecting the patient with a peptide of SEQ ID No. 1, and thereafter evaluating the patient's joint pain when undergoing the same motion.Type: GrantFiled: October 30, 2020Date of Patent: August 16, 2022Assignee: ORTHOTROPHIX, INC.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Publication number: 20220226433Abstract: A diagnostic and a method of treatment are disclosed whereby the diagnostic identifies patients more likely to respond to a therapeutic intervention thereby improving clinical benefits including improved joint function, reduced pain, and other clinical symptoms.Type: ApplicationFiled: September 27, 2021Publication date: July 21, 2022Applicant: Orthotrophix, Inc.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Patent number: 11389505Abstract: A method of alleviating joint pain in a patient comprising evaluating the patient's joint pain when undergoing motions associated stress to the joint, and injecting the patient with a peptide of SEQ ID No. 1, and thereafter evaluating the patient's joint pain when undergoing the same motion.Type: GrantFiled: October 9, 2020Date of Patent: July 19, 2022Assignee: ORTHOTROPHIX, INC.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Publication number: 20220105154Abstract: Compounds, pharmaceutical compositions, and a method of treating hard tissue diseases and disorders are disclosed. The compounds may be a peptide and is structured to bind integrin ?v?3 expressed by osteocytes and by selective binding to the cell surface integrin on hard tissue forming cells regulate three-dimensional bone shape, cartilage formation and repair.Type: ApplicationFiled: September 17, 2021Publication date: April 7, 2022Applicant: ORTHOTROPHIX, INC.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Publication number: 20220047501Abstract: A method of treating osteoarthritis by modifying the shape change of bone(s) underlying articular cartilage, comprising evaluating the bone shape of the patient's joint, injecting the patient with a peptide of SEQ ID No. 1 or applying other therapeutic interventions that can reduce the shape change of the bone(s) underlying articular cartilage, and thereafter evaluating the bone shape of the patient's joint is disclosed.Type: ApplicationFiled: November 2, 2021Publication date: February 17, 2022Applicant: ORTHOTROPHIX, INC.Inventors: Yoshinari KUMAGAI, Dawn McGUIRE, Meghan MILLER, David ROSEN
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Publication number: 20210238237Abstract: A method of alleviating joint pain in a patient comprising evaluating the patient's joint pain when undergoing motions associated stress to the joint, and injecting the patient with a peptide of SEQ ID No. 1, and thereafter evaluating the patient's joint pain when undergoing the same motion.Type: ApplicationFiled: October 30, 2020Publication date: August 5, 2021Applicant: ORTHOTROPHIX, INC.Inventors: Yoshinari KUMAGAI, Dawn McGUIRE, Meghan MILLER, David ROSEN
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Publication number: 20210236595Abstract: A method of alleviating joint pain in a patient comprising evaluating the patient's joint pain when undergoing motions associated stress to the joint, and injecting the patient with a peptide of SEQ ID No. 1, and thereafter evaluating the patient's joint pain when undergoing the same motion.Type: ApplicationFiled: October 9, 2020Publication date: August 5, 2021Applicant: ORTHOTROPHIX, INC.Inventors: Yoshinari KUMAGAI, Dawn McGUIRE, Meghan MILLER, David ROSEN
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Patent number: 10849958Abstract: Knee pain evaluation and management is carried out via intra-articular injections into a patient suffering from knee pain with the injection being comprised of water and a particularly defined peptide. After injection, knee pain is evaluated using a pain subscale such as Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) or Knee injury and Osteoarthritis Outcome Score (KOOS).Type: GrantFiled: June 12, 2018Date of Patent: December 1, 2020Assignee: ORTHOTROPHIX, INC.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Patent number: 10849957Abstract: Making an initial evaluation of patient's joint pain when undergoing motions associated stress to the joint such as going up and down stairs, and injecting the patient with a peptide of SEQ ID No. 1, and thereafter evaluating the patient's joint pain when undergoing the same motion is disclosed.Type: GrantFiled: June 12, 2018Date of Patent: December 1, 2020Assignee: ORTHOTROPHIX, INC.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Patent number: 10849959Abstract: An injectable aqueous formulation as well as a dosage form is disclosed for use in intra-articular injection of a specific peptide of SEQ ID NO: 1, whereby the joint pain at the injection site is relieved in the absence of detectable changes in joint cartilage formation, with pain particularly relieved under certain stress motions such as walking down stairs.Type: GrantFiled: June 12, 2018Date of Patent: December 1, 2020Assignee: ORTHOTROPHIX, INC.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Publication number: 20200170939Abstract: A method of treating osteoarthritis by modifying the shape change of bone(s) underlying articular cartilage, comprising evaluating the bone shape of the patient's joint, injecting the patient with a peptide of SEQ ID No. 1 or applying other therapeutic interventions that can reduce the shape change of the bone(s) underlying articular cartilage, and thereafter evaluating the bone shape of the patient's joint is disclosed.Type: ApplicationFiled: September 27, 2019Publication date: June 4, 2020Applicant: ORTHOTROPHIX, Inc.Inventors: Yoshinari KUMAGAI, Dawn McGUIRE, Meghan MILLER, David ROSEN
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Publication number: 20200129588Abstract: Knee pain caused by osteoarthritis is relieved by modifying the shape change of bone(s) underlying articular cartilage, by a method comprising evaluating the bone shape of the patient's joint, injecting the patient with a peptide of SEQ ID No. 1 or applying other therapeutic interventions that can reduce the shape change of the bone(s) underlying articular cartilage, and thereafter evaluating the bone shape of the patient's joint.Type: ApplicationFiled: September 27, 2019Publication date: April 30, 2020Applicant: ORTHOTROPHIX, Inc.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Publication number: 20200009220Abstract: Knee pain evaluation and management is carried out via intra-articular injections into a patient suffering from knee pain with the injection being comprised of water and a particularly defined peptide. After injection, knee pain is evaluated using a pain subscale such as WOMAC or KOOS.Type: ApplicationFiled: June 12, 2018Publication date: January 9, 2020Applicant: ORTHOTROPHIX, INC.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Publication number: 20200002393Abstract: A method of alleviating joint pain in a patient comprising evaluating the patient's joint pain when undergoing motions associated stress to the joint, and injecting the patient with a peptide of SEQ ID No. 1, and thereafter evaluating the patient's joint pain when undergoing the same motion.Type: ApplicationFiled: June 12, 2018Publication date: January 2, 2020Applicant: ORTHOTROPHIX, INC.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Publication number: 20190388503Abstract: An injectable aqueous formulation as well as a dosage form is disclosed for use in intra-articular injection of a specific peptide of SEQ ID NO: 1, whereby the joint pain at the injection site is relieved in the absence of detectable changes in joint cartilage formation, with pain particularly relieved under certain stress motions such as walking down stairs.Type: ApplicationFiled: June 12, 2018Publication date: December 26, 2019Applicant: ORTHOTROPHIX, INC.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Patent number: 8426558Abstract: The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.Type: GrantFiled: December 15, 2010Date of Patent: April 23, 2013Assignee: OrthoTrophix, Inc.Inventors: Catherine Middleton-Hardie, Mirella Lazarov, David Rosen
