Patents Assigned to Orthox Limited
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Patent number: 11717410Abstract: An implantable tissue repair device containing a body having a biocompatible hydrogel and a plurality of tissue anchoring elements projecting from the body, where the anchoring elements are integrally formed with the body and have the same biocompatible hydrogel as the body, and the anchoring elements, in use, are arranged to enter apertures in a tissue and anchor the device to the tissue.Type: GrantFiled: May 22, 2018Date of Patent: August 8, 2023Assignee: ORTHOX LIMITEDInventors: Robert Alan Walker, Ben Armstrong, Nicholas James Vavasour Skaer
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Publication number: 20200205986Abstract: An implantable tissue repair device for the repair, replacement or augmentation of a tissue, the device having a biocompatible solvated structural material, where at least part of the structural material is in a compressed and/or dried state.Type: ApplicationFiled: May 18, 2018Publication date: July 2, 2020Applicant: ORTHOX LIMITEDInventors: Nicholas James Vavasour SKAER, Robert Alan WALKER
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Publication number: 20200155322Abstract: An implantable tissue repair device containing a body having a biocompatible hydrogel and a plurality of tissue anchoring elements projecting from the body, where the anchoring elements are integrally formed with the body and have the same biocompatible hydrogel as the body, and the anchoring elements, in use, are arranged to enter apertures in a tissue and anchor the device to the tissue.Type: ApplicationFiled: May 22, 2018Publication date: May 21, 2020Applicant: ORTHOX LIMITEDInventors: ROBERT Alan WALKER, Ben ARMSTRONG, Nicholas James Vavasour SKAER
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Publication number: 20200069430Abstract: An implantable tissue repair device containing a body having a biocompatible hydrogel and a rigid support at least partly located within the body or device, or connected to the body or device.Type: ApplicationFiled: May 22, 2018Publication date: March 5, 2020Applicant: ORTHOX LIMITEDInventors: Robert ALAN WALKER, Ben ARMSTRONG, Nicholas James Vavasour SKAER
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Patent number: 9943412Abstract: An implantable repair device for the repair, augmentation or replacement of tissue, uses silk fibroin and has a smooth surface and a porous surface. The smooth surface has a measured Sa value of less than approximately 0.1 ?m when using Atomic Force Microscopy when samples of the repair device are fully hydrated by imaging through fluid in peak force tapping mode. A method of preparing such an implantable repair device includes preparing a gel from a fibroin solution in a mold, preparing a material by subjecting the gel to one or more steps of freezing and thawing the gel, and creating at least a porous surface on the device, wherein a portion of the mold is adapted to provide at least one smooth surface.Type: GrantFiled: October 18, 2012Date of Patent: April 17, 2018Assignee: ORTHOX LIMITEDInventor: Nicholas Skaer
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Patent number: 9226992Abstract: A cartilaginous tissue repair device with a biocompatible, bioresorbable three-dimensional silk or other fiber lay and a biocompatible, bioresorbable substantially porous silk-based or other hydrogel partially or substantially filling the interstices of the fiber lay; with or without an integral means of firmly anchoring the device to a patient's bone.Type: GrantFiled: August 17, 2006Date of Patent: January 5, 2016Assignee: Orthox LimitedInventors: Stephen Mann, David Philip Knight, Nicholas James Vavasour Skaer, Caroline Bertram, Richard O. C. Oreffo, Helmtrud I. Roach, Andrew Michael Collins
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Publication number: 20140277452Abstract: An implantable repair device for the repair, augmentation or replacement of tissue, uses silk fibroin and has a smooth surface and a porous surface. The smooth surface has a measured Sa value of less than approximately 0.1 ?m when using Atomic Force Microscopy when samples of the repair device are fully hydrated by imaging through fluid in peak force tapping mode. A method of preparing such an implantable repair device includes preparing a gel from a fibroin solution in a mould, preparing a material by subjecting the gel to one or more steps of freezing and thawing the gel, and creating at least a porous surface on the device, wherein a portion of the mould is adapted to provide at least one smooth surface.Type: ApplicationFiled: October 18, 2012Publication date: September 18, 2014Applicant: ORTHOX LIMITEDInventor: Nicholas Skaer
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Patent number: 8337938Abstract: A method for the preparation of a regenerated silk fibroin solution comprises the steps of: treating silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between ?0.001 and ?0.05 at 25° C.; and subsequently degumming the treated silk or silk cocoons; or alternatively, degumming silk or silk cocoons; and subsequently treating the degummed silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between ?0.001 and ?0.05 at 25° C. The invention also extends to fibroin solution, a fibroin material and an implant useful for cartilage repair.Type: GrantFiled: February 8, 2012Date of Patent: December 25, 2012Assignee: Orthox LimitedInventors: David Philip Knight, Nicholas James Vavasour Skaer, Andrew Michael Collins, Tom Louis Dirk Gheysens, Christopher Holland
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Patent number: 8128984Abstract: A method for the preparation of a regenerated silk fibroin solution comprises the steps of: treating silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between ?0.001 and ?0.05 at 25° C.; and subsequently degumming the treated silk or silk cocoons; or alternatively, degumming silk or silk cocoons; and subsequently treating the degummed silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between ?0.001 and ?0.05 at 25° C. The invention also extends to fibroin solution, a fibroin material and an implant useful for cartilage repair.Type: GrantFiled: April 30, 2009Date of Patent: March 6, 2012Assignee: Orthox LimitedInventors: David Philip Knight, Nicholas James Vavasour Skaer, Andrew Michael Collins, Tom Louis Dirk Gheysens, Christopher Holland
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Publication number: 20110172394Abstract: A method for the preparation of an implantable material for the repair, augmentation or replacement of bone from a fibroin solution, the method comprising the steps of: preparing a gel from the fibroin solution; preparing a material by subjecting the gel to one or more steps of freezing and thawing the gel, wherein the step of preparing the gel from the fibroin solution is performed in the presence of phosphate ions. The material may be treated with calcium ionstoform a fibroin-apatite. A further method comprises the step of treating the material with an isocyanate. The invention also extends to a method for the preparation of an implantable material, wherein a regenerated fibroin solution is used. Also, there is an implantable material and an implant.Type: ApplicationFiled: June 24, 2009Publication date: July 14, 2011Applicant: ORTHOX LIMITEDInventors: David Knight, Nicholas Skaer, Andrew Collins, Tom Louis Dirk Gheysens