Patents Assigned to Osaka City University
  • Patent number: 11951229
    Abstract: To provide a liquid medical material maintaining a colloid in a more sol form than a solid at normal temperature, having a higher function as a wound dressing material and a hemostatic material than fibrin glue, and being able to be produced safely and inexpensively. A gelatin aqueous solution including calcium at a concentration of 0.2 M or more and 1.0 M or less, and having a concentration of 5% by weight or more and 40% by weight or less, an average molecular weight of 80,000 or more and 120,000 or less, and a molecular weight distribution of 20,000 or more and 300,000 or less, and transglutaminase inducing crosslinking of the gelatin, are included. It is preferable that the calcium has a concentration of 0.2 M or more and 0.7 M or less, the gelatin has a bloom of 160 or more and 250 or less, and the transglutaminase has activity per unit of 36 U/ml to 400 U/ml.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: April 9, 2024
    Assignees: AOBAKASEI KABUSHIKI KAISHA, OSAKA CITY UNIVERSITY IN UNIVERSITY PUBLIC CORPORATION OSAKA
    Inventors: Hirotsugu Kido, Katsunori Chiba, Hironori Arima, Kenji Ohata
  • Patent number: 11844776
    Abstract: The present invention provides a means for treating and/or preventing peripheral nerve disorder by facilitating regeneration of peripheral nerves. Specifically, the present invention provides a composition for treating and/or preventing peripheral nerve disorder comprising a compound represented by the general formula (I): wherein R1 is lower alkyl substituted with lower alkoxy, lower alkyl substituted with a heterocyclic group, a heterocyclic group, or a group represented by the formula (IIa): R4O—R5m??(IIa) wherein R4 is lower alkyl, R5 is lower alkylene, and m is an integer of 1 to 6; R2 is lower alkyl optionally substituted with phenyl; and R3 is lower alkyl optionally substituted with halogen, lower alkoxy, or phenyl; condensed polycyclic hydrocarbon; or hydrogen.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: December 19, 2023
    Assignees: OSAKA CITY UNIVERSITY, SENJU PHARMACEUTICAL CO., LTD.
    Inventor: Shinji Hirotsune
  • Publication number: 20230266606
    Abstract: A three-dimensional display system, a head up display system, and a mobile object including a head up display system include a display apparatus, barrier, detection apparatus, and controller. The display apparatus has subpixels arranged in a grid along orthogonal first and second directions and displays left- and right-eye images respectively in first subpixels and second subpixels separated by a display boundary from among the subpixels. The barrier has a light shielding region that shields the left-eye image and the right-eye image, and a light transmitting region that causes at least part of the left-eye image to reach a left eye of a user and at least part of the right-eye image to reach a right eye of the user. The detection apparatus detects the left and right eye positions. The controller moves the display boundary based on at least a change in the positions of the left and right eyes.
    Type: Application
    Filed: May 1, 2023
    Publication date: August 24, 2023
    Applicants: OSAKA CITY UNIVERSITY, KYOCERA Corporation
    Inventors: Hideya TAKAHASHI, Goro HAMAGISHI, Kaoru KUSAFUKA
  • Patent number: 11675211
    Abstract: A three-dimensional display apparatus comprises a display panel (display element) and a parallax barrier (optical element). The display panel displays a left-eye image and a right-eye image respectively in first subpixels and second subpixels. The parallax barrier transmits at least part of the left-eye image toward the left eye, and at least part of the right-eye image toward the right eye. A first certain number of the first subpixels and of the second subpixels are each successively arranged in each column. A region in which the first subpixels are arranged and a region in which the second subpixels are arranged are displaced from each other by a second certain number between two adjacent columns. The first certain number is greater than the second certain number and is not a multiple of the second certain number.
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: June 13, 2023
    Assignees: OSAKA CITY UNIVERSITY, KYOCERA Corporation
    Inventors: Hideya Takahashi, Goro Hamagishi, Kaoru Kusafuka
  • Patent number: 11629889
    Abstract: A geothermal heat utilization system (10) includes a pumping well (20), a water injection well (30), a pipe (13) having two ends which are immersed in water stored in the pumping well (20) and the water injection well (30) so as to connect the pumping well (20) and the water injection well (30) to each other, a pump (21) and a pump (31) which are respectively provided inside the pumping well (20) and the water injection well (30) and pump up stored water through the pipe (13), a valve (25) and a valve (35) which are respectively provided on a pressurization side of the pump (21) inside the pumping well (20) and a pressurization side of the pump (31) inside the water injection well (30), and a heat exchanger (14) which is configured to exchange heat with the pipe (13).
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: April 18, 2023
    Assignees: MITSUBISHI HEAVY INDUSTRIES THERMAL SYSTEMS, LTD., OSAKA CITY UNIVERSITY, NEWJEC INC., THE KANSAI ELECTRIC POWER CO., INC., MORIKAWA SAKUSEN INDUSTRIES CO., LTD.
    Inventors: Masanobu Sakai, Takeshi Fuchimoto, Rinnichi Sai, Masaki Nakao, Kazuhiro Nakamura, Yasuhisa Nakaso, Toshihide Morikawa, Shinsuke Sakae
  • Publication number: 20220340646
    Abstract: [Summary] [Purpose] The invention provides a novel therapeutic agent or prophylactic agent for cognitive disorders. [Solution Means] The invention provides an antibody that participates in antigen-antibody reaction specifically with tau protein that has been phosphorylated in the vicinity of Ser413 of SEQ ID NO: 1, and a therapeutic agent or prophylactic agent for cognitive disorders comprising as an active ingredient a peptide that has been phosphorylated in the vicinity of Ser413.
    Type: Application
    Filed: December 1, 2021
    Publication date: October 27, 2022
    Applicants: OSAKA CITY UNIVERSITY, TEIJIN PHARMA LIMITED
    Inventors: Hiroshi MORI, Takami TOMIYAMA, Yoichi MATSUMOTO, Hiroshi EGUCHI, Yuichi KUNORI
  • Publication number: 20220082854
    Abstract: A three-dimensional display apparatus comprises a display panel (display element) and a parallax barrier (optical element). The display panel displays a left-eye image and a right-eye image respectively in first subpixels and second subpixels. The parallax barrier transmits at least part of the left-eye image toward the left eye, and at least part of the right-eye image toward the right eye. A first certain number of the first subpixels and of the second subpixels are each successively arranged in each column. A region in which the first subpixels are arranged and a region in which the second subpixels are arranged are displaced from each other by a second certain number between two adjacent columns. The first certain number is greater than the second certain number and is not a multiple of the second certain number.
    Type: Application
    Filed: November 23, 2021
    Publication date: March 17, 2022
    Applicants: OSAKA CITY UNIVERSITY, KYOCERA Corporation
    Inventors: Hideya TAKAHASHI, Goro Hamagishi, Kaoru Kusafuka
  • Publication number: 20220054701
    Abstract: To provide a liquid medical material maintaining a colloid in a more sol form than a solid at normal temperature, having a higher function as a wound dressing material and a hemostatic material than fibrin glue, and being able to be produced safely and inexpensively. A gelatin aqueous solution including calcium at a concentration of 0.2 M or more and 1.0 M or less, and having a concentration of 5% by weight or more and 40% by weight or less, an average molecular weight of 80,000 or more and 120,000 or less, and a molecular weight distribution of 20,000 or more and 300,000 or less, and transglutaminase inducing crosslinking of the gelatin, are included. It is preferable that the calcium has a concentration of 0.2 M or more and 0.7 M or less, the gelatin has a bloom of 160 or more and 250 or less, and the transglutaminase has activity per unit of 36 U/ml to 400 U/ml.
    Type: Application
    Filed: August 20, 2021
    Publication date: February 24, 2022
    Applicants: AOBAKASEI KABUSHIKI KAISHA, OSAKA CITY UNIVERSITY IN UNIVERSITY PUBLIC CORPORATION OSAKA
    Inventors: Hirotsugu KIDO, Katsunori CHIBA, Hironori ARIMA, Kenji OHATA
  • Patent number: 11215820
    Abstract: A three-dimensional display apparatus comprises a display panel (display element) and a parallax barrier (optical element). The display panel displays a left-eye image and a right-eye image respectively in first subpixels and second subpixels. The parallax barrier transmits at least part of the left-eye image toward the left eye, and at least part of the right-eye image toward the right eye. A first certain number of the first subpixels and of the second subpixels are each successively arranged in each column. A region in which the first subpixels are arranged and a region in which the second subpixels are arranged are displaced from each other by a second certain number between two adjacent columns. The first certain number is greater than the second certain number and is not a multiple of the second certain number.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: January 4, 2022
    Assignees: OSAKA CITY UNIVERSITY, KYOCERA Corporation
    Inventors: Hideya Takahashi, Goro Hamagishi, Kaoru Kusafuka
  • Patent number: 10974062
    Abstract: The present invention includes: a front-side positive trace (2P) disposed on a flexible substrate (5); a positive external connection line (12P) connected to the front-side positive trace (2P) to supply electric power; and LED chips (4) provided to the flexible substrate (5) and connected to the front-side positive trace (2P), wherein an electric resistance between the positive external connection line (12P) and one of the LED chips (4) which is farthest from the positive external connection line (12P) is less than an internal resistance of the one of the LED chips (4).
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: April 13, 2021
    Assignees: SHARP KABUSHIKI KAISHA, OSAKA CITY UNIVERSITY, SBI PHARMACEUTICALS CO.. LTD.
    Inventors: Katsuji Iguchi, Hiroya Sato, Takashi Yoshimoto, Jun Mori, Toshiyuki Ozawa, Kunio Awazu
  • Patent number: 10905341
    Abstract: A cancer invasiveness diagnosis system includes an endoscope; a microtomography probe which is introduced into a body cavity together with the endoscope, the microtomography probe emitting a low-coherence light on a target tissue in which a target tumor is present to obtain an optical interference signal; a determination portion which is configured to obtain a tomography image of the target tissue including the target tumor and a blood flow velocity information in a blood vessel in the tomography image based on the optical interference signal, wherein the determination portion is configured to determine the cancer invasiveness of the target tumor based on the tomography image and the blood flow velocity information.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: February 2, 2021
    Assignee: OSAKA CITY UNIVERSITY
    Inventors: Souichi Saeki, Masatsugu Shiba
  • Patent number: 10845129
    Abstract: A geothermal heat utilization system includes a heat source well facility, a heat source device having a refrigeration cycle including a compressor, a condenser, an expanded portion, and an evaporator, a primary refrigerant circuit that is connected to a first unit which is one of the condenser and the evaporator of the heat source device, heat exchange being able to be performed between the first unit and the well-side pipe, a secondary refrigerant circuit that is connected to a second unit which is the other of the condenser and the evaporator of the heat source device, heat exchange being able to be performed between the second unit and a load, and a mode switching unit that switches between a cold heat storage operation mode in which the primary refrigerant circuit is connected to the evaporator and the secondary refrigerant circuit is connected to the condenser and a cold heat discharge operation mode in which the primary refrigerant circuit is connected to the condenser and the secondary refrigerant cir
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: November 24, 2020
    Assignees: MITSUBISHI HEAVY INDUSTRIES THERMAL SYSTEMS, LTD., THE KANSAI ELECTRIC POWER CO., INC., OSAKA CITY UNIVERSITY, NEWJEC INC.
    Inventors: Masanobu Sakai, Takeshi Fuchimoto, Rinnichi Sai, Yasuhisa Nakaso, Shinsuke Sakae, Masaki Nakao, Masatoshi Nishioka, Kazuhiro Nakamura
  • Patent number: 10808968
    Abstract: A thermoacoustic cooling device includes a tube in which a working fluid is enclosed; a first stack that generates acoustic waves in the working fluid with use of a temperature gradient; a first high-temperature heat exchanger provided at a first side of the first stack to heat the first side of the first stack; a first low-temperature heat exchanger provided at a second side of the first stack; a second stack in which a temperature gradient is generated by the acoustic waves; a second high-temperature heat exchanger provided at a first side of the second stack, which has a high temperature; a second low-temperature heat exchanger provided at a second side of the second stack, which has a low temperature; and a heat transfer portion configured to connect the second low-temperature heat exchanger to the first low-temperature heat exchanger so as to transfer heat therebetween.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: October 20, 2020
    Assignees: JTEKT CORPORATION, PUBLIC UNIVERSITY CORPORATION OSAKA CITY UNIVERSITY
    Inventors: Toshiyuki Saito, Ryouichi Takahata, Tomoyuki Takei, Osamu Ishikawa
  • Patent number: 10765451
    Abstract: A retractor holds a surgical incision in a body in an opened state to ensure a surgical field in small-incision endoscopic surgery, and includes a base body that is a thin plate made of tin having a purity of not less than 99.9% and has an elongated rectangular shape in an extended state of the base body. The retractor, in an extended form in a rectangular shape or in a rounded form in a small shape, can be inserted from a small incision wound into the body, and can easily be delivered to the surgical incision in the body by a surgical instrument. The base body is bent and deformed into a desired shape by the surgical instrument and is applied to the surgical incision in the body, so that the surgical incision can be held in an opened state so as to ensure the surgical field.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: September 8, 2020
    Assignees: OSAKA CITY UNIVERSITY, OZK CO., LTD., SHINWA SYOJI CO., LTD.
    Inventors: Toshihiko Shibata, Haruhiko Yamasaki, Katsunori Mitsuhashi, Yoshiro Morishita
  • Patent number: 10750988
    Abstract: A fatigue degree determination device includes a fatigue degree determination unit. A first biological heart rate is acquired while a user is awake and at rest, based on a biological heart rate measured from the user. A second biological heart rate is acquired while the user is sleeping, based on the biological heart rate measured from the user. The fatigue degree determination unit determines a fatigue degree of the user, based on information read out from a storage medium, the first biological heart rate and the second biological heart rate. The storage medium stores the information in which a degree of change of one biological heart rate relative to the other biological heart rate of a biological heart rate while a person is awake and at rest and a biological heart rate while the person is sleeping and a fatigue degree are associated with each other.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: August 25, 2020
    Assignees: OMRON HEALTHCARE Co., Ltd., OSAKA CITY UNIVERSITY
    Inventors: Kenji Fujii, Shingo Yamashita, Yasuyoshi Watanabe, Kei Mizuno
  • Patent number: 10697004
    Abstract: A method in which a mutant gene present in a gene pool mixedly with a large number of wild-type genes can be simply, inexpensively and sensitively detected is developed and provided. A clamping probe that is connected to a target nucleic acid molecule in two regions of first and second target nucleic acid complementary regions so that a wild-type target nucleic acid molecule and a mutant-type target nucleic acid molecule can be distinguished from each other depending on a difference in complementarity to these target nucleic acid molecules is provided.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: June 30, 2020
    Assignee: Osaka City University
    Inventors: Akira Tachibana, Toshizumi Tanabe
  • Publication number: 20200148753
    Abstract: [PURPOSE] The invention provides a novel therapeutic agent or prophylactic agent for cognitive disorders. [SOLUTION MEANS] The invention provides an antibody that participates in antigen-antibody reaction specifically with tau protein that has been phosphorylated in the vicinity of Ser413 of SEQ ID NO: 1, and a therapeutic agent or prophylactic agent for cognitive disorders comprising as an active ingredient a peptide that has been phosphorylated in the vicinity of Ser413.
    Type: Application
    Filed: June 10, 2019
    Publication date: May 14, 2020
    Applicants: OSAKA CITY UNIVERSITY, TEIJIN PHARMA LIMITED
    Inventors: Hiroshi Mori, Takami Tomiyama, Yoichi Matsumoto, Hiroshi Eguchi, Yuichi Kunori
  • Publication number: 20200025419
    Abstract: A geothermal heat utilization system (10) includes a pumping well (20), a water injection well (30), a pipe (13) having two ends which are immersed in water stored in the pumping well (20) and the water injection well (30) so as to connect the pumping well (20) and the water injection well (30) to each other, a pump (21) and a pump (31) which are respectively provided inside the pumping well (20) and the water injection well (30) and pump up stored water through the pipe (13), a valve (25) and a valve (35) which are respectively provided on a pressurization side of the pump (21) inside the pumping well (20) and a pressurization side of the pump (31) inside the water injection well (30), and a heat exchanger (14) which is configured to exchange heat with the pipe (13).
    Type: Application
    Filed: March 28, 2018
    Publication date: January 23, 2020
    Applicants: MITSUBISHI HEAVY INDUSTRIES THERMAL SYSTEMS, LTD., OSAKA CITY UNIVERSITY, NEWJEC INC., THE KANSAI ELECTRIC POWER CO., INC., MORIKAWA SAKUSEN INDUSTRIES CO., LTD.
    Inventors: Masanobu SAKAI, Takeshi FUCHIMOTO, Rinnichi SAI, Masaki NAKAO, Kazuhiro NAKAMURA, Yasuhisa NAKASO, Toshihide MORIKAWA, Shinsuke SAKAE
  • Publication number: 20190377177
    Abstract: A three-dimensional display apparatus 3 comprises a display panel 5 (display element) and a parallax barrier 6 (optical element). The display panel 5 displays a left-eye image and a right-eye image respectively in first subpixels 11L and second subpixels 11R. The parallax barrier 6 transmits at least part of the left-eye image toward the left eye, and at least part of the right-eye image toward the right eye. A first sertain number of the first subpixels 11L and of the second subpixels 11R are each successively arranged in each column. A region in which the first subpixels 11L are arranged and a region in which the second subpixels 11R are arranged are displaced from each other by a second sertain number between two adjacent columns. The first sertain number is greater than the second sertain number and is not a multiple of the second sertain number.
    Type: Application
    Filed: January 26, 2018
    Publication date: December 12, 2019
    Applicants: OSAKA CITY UNIVERSITY, KYOCERA Corporation
    Inventors: Hideya TAKAHASHI, Goro HAMAGISHI, Kaoru KUSAFUKA
  • Publication number: 20190314320
    Abstract: The present invention provides a means for treating and/or preventing peripheral nerve disorder by facilitating regeneration of peripheral nerves. Specifically, the present invention provides a composition for treating and/or preventing peripheral nerve disorder comprising a compound represented by the general formula (I): wherein R1 is lower alkyl substituted with lower alkoxy, lower alkyl substituted with a heterocyclic group, a heterocyclic group, or a group represented by the formula (IIa): R4?O—R5?m??(IIa) wherein R4 is lower alkyl, R5 is lower alkylene, and m is an integer of 1 to 6; R2 is lower alkyl optionally substituted with phenyl; and R3 is lower alkyl optionally substituted with halogen, lower alkoxy, or phenyl; condensed polycyclic hydrocarbon; or hydrogen.
    Type: Application
    Filed: May 22, 2017
    Publication date: October 17, 2019
    Applicants: OSAKA CITY UNIVERSITY, SENJU PHARMACEUTICAL CO., LTD.
    Inventor: Shinji HIROTSUNE