Patents Assigned to OSAKA CITY UNIVERSITY IN UNIVERSITY PUBLIC CORPORATION OSAKA
  • Patent number: 11951229
    Abstract: To provide a liquid medical material maintaining a colloid in a more sol form than a solid at normal temperature, having a higher function as a wound dressing material and a hemostatic material than fibrin glue, and being able to be produced safely and inexpensively. A gelatin aqueous solution including calcium at a concentration of 0.2 M or more and 1.0 M or less, and having a concentration of 5% by weight or more and 40% by weight or less, an average molecular weight of 80,000 or more and 120,000 or less, and a molecular weight distribution of 20,000 or more and 300,000 or less, and transglutaminase inducing crosslinking of the gelatin, are included. It is preferable that the calcium has a concentration of 0.2 M or more and 0.7 M or less, the gelatin has a bloom of 160 or more and 250 or less, and the transglutaminase has activity per unit of 36 U/ml to 400 U/ml.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: April 9, 2024
    Assignees: AOBAKASEI KABUSHIKI KAISHA, OSAKA CITY UNIVERSITY IN UNIVERSITY PUBLIC CORPORATION OSAKA
    Inventors: Hirotsugu Kido, Katsunori Chiba, Hironori Arima, Kenji Ohata
  • Publication number: 20220054701
    Abstract: To provide a liquid medical material maintaining a colloid in a more sol form than a solid at normal temperature, having a higher function as a wound dressing material and a hemostatic material than fibrin glue, and being able to be produced safely and inexpensively. A gelatin aqueous solution including calcium at a concentration of 0.2 M or more and 1.0 M or less, and having a concentration of 5% by weight or more and 40% by weight or less, an average molecular weight of 80,000 or more and 120,000 or less, and a molecular weight distribution of 20,000 or more and 300,000 or less, and transglutaminase inducing crosslinking of the gelatin, are included. It is preferable that the calcium has a concentration of 0.2 M or more and 0.7 M or less, the gelatin has a bloom of 160 or more and 250 or less, and the transglutaminase has activity per unit of 36 U/ml to 400 U/ml.
    Type: Application
    Filed: August 20, 2021
    Publication date: February 24, 2022
    Applicants: AOBAKASEI KABUSHIKI KAISHA, OSAKA CITY UNIVERSITY IN UNIVERSITY PUBLIC CORPORATION OSAKA
    Inventors: Hirotsugu KIDO, Katsunori CHIBA, Hironori ARIMA, Kenji OHATA