Patents Assigned to Osel, Inc.
  • Patent number: 11571458
    Abstract: Methods are described for increasing levels of healthy vaginal bacteria by treating the vaginal mucosa with bacteriocins derived from Lactobacillus paragasseri, Lactobacillus gasseri, and other bacterial strains. The bacteriocins are surprisingly advantageous as being selectively active against Lactobacillus iners but relatively inactive against H2O2-producing Lactobacillus species. Because L. iners is involved in the onset and maintenance of vaginal dysbiosis, selective removal of this bacterium from the vaginal microbiome treats or prevents conditions associated with vaginal dysbiosis, such as bacterial vaginosis and its sequelae.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: February 7, 2023
    Assignee: Osel, Inc.
    Inventors: Thomas P. Parks, Trine Nilsen
  • Patent number: 11278581
    Abstract: This invention provides for a method for improving the success rate of in vitro fertilization in women hosting abnormal vaginal microbiota. The method comprises the steps of: (i) selecting a woman suspected of hosting abnormal vaginal microbiota (AVM); (ii) administering to the woman a suitable antibiotic administered in an amount and duration effective to reduce the quantity of abnormal vaginal microbiota hosted by the woman; (iii) administering to the woman via vaginal administration an amount of Lactobacillus species in an amount sufficient to colonize the vaginal mucosa; and, (iv) transferring an embryo to the woman.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: March 22, 2022
    Assignee: Osel, Inc.
    Inventors: Thomas P. Parks, Peter Humaidan, Jørgen Skov Jensen, Niels Uldbjerg, Thor Haahr
  • Patent number: 11083761
    Abstract: This invention provides for a dry preserved formulation of Lactobacillus suitable for administration to people as a pro-biotic or live biotherapeutic treatment where the formulation is stable, has high potency, and contains no animal-derived excipients.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: August 10, 2021
    Assignee: Osel, Inc.
    Inventors: Thomas P. Parks, Angela Marcobal
  • Patent number: 8642029
    Abstract: The present invention relates to methods and compositions for Lactobacillus Replacement Therapy (LRT). Methods for improved stability and recovery of dried bacterial preparations are also provided.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: February 4, 2014
    Assignee: Osel, Inc.
    Inventors: Jun Wang, Yang Liu, Qiang Xu
  • Patent number: 8329447
    Abstract: The invention provides a naturally occurring strain of Lactobacillus crispatus with advantageous characteristics. The strain colonizes mucosal surfaces, particularly vaginal surfaces. The strain is also capable of rapid growth in a number of conditions and is highly viable after desiccation. Moreover, the strain is capable of preventing and reducing pathogenic infection of vaginal mucosa.
    Type: Grant
    Filed: December 9, 2009
    Date of Patent: December 11, 2012
    Assignee: Osel, Inc.
    Inventors: Yang Liu, Rosa R. Yu, Andrew Cheng, Qing Xia, Qiang Xu
  • Publication number: 20110135615
    Abstract: The present invention relates to methods and compositions for Lactobacillus Replacement Therapy (LRT). Methods for improved stability and recovery of dried bacterial preparations are also provided.
    Type: Application
    Filed: March 30, 2009
    Publication date: June 9, 2011
    Applicant: Osel, Inc.
    Inventors: Jun Wang, Yang Liu, Qiang Xu
  • Publication number: 20110066137
    Abstract: The present invention relates to applicators for applying powders to the vaginal mucosa.
    Type: Application
    Filed: December 17, 2008
    Publication date: March 17, 2011
    Applicant: OSEL, Inc.
    Inventors: Thomas Parks, Troy Just
  • Patent number: 7833791
    Abstract: The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: November 16, 2010
    Assignee: Osel, Inc.
    Inventors: Chia-Hwa Chang, David A. Simpson, Theresa Li-Yun Chang, Qiang Xu, John A. Lewicki
  • Patent number: 7754467
    Abstract: Methods and compositions for targeting heterologous polypeptides to bacterial cell walls are provided.
    Type: Grant
    Filed: January 28, 2004
    Date of Patent: July 13, 2010
    Assignee: Osel, Inc.
    Inventors: Chia-Hwa Chang, Xiaowen Liu, John A. Lewicki, Qiang Xu
  • Publication number: 20100151026
    Abstract: The invention provides a naturally occurring strain of Lactobacillus crispatus with advantageous characteristics. The strain colonizes mucosal surfaces, particularly vaginal surfaces. The strain is also capable of rapid growth in a number of conditions and is highly viable after desiccation. Moreover, the strain is capable of preventing and reducing pathogenic infection of vaginal mucosa.
    Type: Application
    Filed: December 9, 2009
    Publication date: June 17, 2010
    Applicant: Osel, Inc.
    Inventors: Yang Liu, Rosa R. Yu, Andrew Cheng, Qing Xia, Qiang Xu
  • Publication number: 20090155304
    Abstract: This disclosure relates to a modified version of cyanovirin-N protein and a transformed Lactobacillus bacterium that is capable of recombinantly expressing this modified protein. Further disclosed are polynucleotide sequence encoding the modified cyanovirin-N protein, expression cassette that allows the expression of the modified protein, and method of make and use of the modified protein as well as the transformed Lactobacillus bacterium. In addition, this disclosure describes two novel promoters originated from L. jensenii, which are capable of directing a high level of gene expression in Lactobacillus bacteria. Also described are an expression cassette comprising one of the novel promoters, a genetically modified Lactobacillus bacterium containing the expression cassette, a method for recombinant gene expression in Lactobacillus bacteria using the novel promoters, and a method for delivery of proteins with desired biological activity to a mucosal surface in a human.
    Type: Application
    Filed: November 24, 2008
    Publication date: June 18, 2009
    Applicant: Osel, Inc.
    Inventors: Xiaowen Liu, Kirsten Essenmacher, David A. Simpson, Qiang Xu
  • Publication number: 20090148408
    Abstract: The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.
    Type: Application
    Filed: November 9, 2007
    Publication date: June 11, 2009
    Applicant: Osel, Inc.
    Inventors: Chia-Hwa Chang, David A. Simpson, Theresa Li-Yun Chang, Qiang Xu, John A. Lewicki
  • Patent number: 7456011
    Abstract: This disclosure relates to a modified version of cyanovirin-N protein and a transformed Lactobacillus bacterium that is capable of recombinantly expressing this modified protein. Further disclosed are polynucleotide sequence encoding the modified cyanovirin-N protein, expression cassette that allows the expression of the modified protein, and method of make and use of the modified protein as well as the transformed Lactobacillus bacterium. In addition, this disclosure describes two novel promoters originated from L. jensenii, which are capable of directing a high level of gene expression in Lactobacillus bacteria. Also described are an expression cassette comprising one of the novel promoters, a genetically modified Lactobacillus bacterium containing the expression cassette, a method for recombinant gene expression in Lactobacillus bacteria using the novel promoters, and a method for delivery of proteins with desired biological activity to a mucosal surface in a human.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: November 25, 2008
    Assignee: Osel, Inc.
    Inventors: Xiaowen Liu, Kirsten Essenmacher, David A. Simpson, Qiang Xu
  • Patent number: 7312076
    Abstract: The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: December 25, 2007
    Assignee: Osel, Inc.
    Inventors: Chia-Hwa Chang, David A. Simpson, Theresa Li-Yun Chang, Qiang Xu, John A. Lewicki
  • Publication number: 20070117197
    Abstract: The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.
    Type: Application
    Filed: January 5, 2007
    Publication date: May 24, 2007
    Applicant: Osel, Inc.
    Inventors: Chia-Hwa Chang, David Simpson, Theresa Chang, Qiang Xu, John Lewicki
  • Patent number: 7179458
    Abstract: The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: February 20, 2007
    Assignee: Osel, Inc.
    Inventors: Chia-Hwa Chang, David A. Simpson, Theresa Li-Yun Chang, Qiang Xu, John A. Lewicki
  • Publication number: 20060194226
    Abstract: This disclosure relates to a modified version of cyanovirin-N protein and a transformed Lactobacillus bacterium that is capable of recombinantly expressing this modified protein. Further disclosed are polynucleotide sequence encoding the modified cyanovirin-N protein, expression cassette that allows the expression of the modified protein, and method of make and use of the modified protein as well as the transformed Lactobacillus bacterium. In addition, this disclosure describes two novel promoters originated from L. jensenii, which are capable of directing a high level of gene expression in Lactobacillus bacteria. Also described are an expression cassette comprising one of the novel promoters, a genetically modified Lactobacillus bacterium containing the expression cassette, a method for recombinant gene expression in Lactobacillus bacteria using the novel promoters, and a method for delivery of proteins with desired biological activity to a mucosal surface in a human.
    Type: Application
    Filed: January 12, 2006
    Publication date: August 31, 2006
    Applicant: Osel, Inc.
    Inventors: Xiaowen Liu, Kirsten Essenmacher, David Simpson, Qiang Xu
  • Publication number: 20050003510
    Abstract: Methods and compositions for targeting heterologous polypeptides to bacterial cell walls are provided.
    Type: Application
    Filed: January 28, 2004
    Publication date: January 6, 2005
    Applicant: OSEL, INC.
    Inventors: Chia-Hwa Chang, Xiaowen Liu, John Lewicki, Qiang Xu
  • Publication number: 20030228297
    Abstract: The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.
    Type: Application
    Filed: March 6, 2003
    Publication date: December 11, 2003
    Applicant: Osel, Inc.
    Inventors: Chia-Hwa Chang, David A. Simpson, Theresa Li-Yun Chang, Qiang Xu, John A. Lewicki
  • Publication number: 20020086020
    Abstract: This invention relates to methods of increasing the half-life of a viral-specific ligand on a mucosal membrane by modifying the viral-specific ligand to bind the bacteria colonized on the mucosal membrane. The invention also provides a chimeric molecule comprising a viral-specific ligand and a bacterial-specific ligand.
    Type: Application
    Filed: January 10, 2002
    Publication date: July 4, 2002
    Applicant: OSEL, INC.
    Inventor: Peter P. Lee