Patents Assigned to Osel, Inc.
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Patent number: 11571458Abstract: Methods are described for increasing levels of healthy vaginal bacteria by treating the vaginal mucosa with bacteriocins derived from Lactobacillus paragasseri, Lactobacillus gasseri, and other bacterial strains. The bacteriocins are surprisingly advantageous as being selectively active against Lactobacillus iners but relatively inactive against H2O2-producing Lactobacillus species. Because L. iners is involved in the onset and maintenance of vaginal dysbiosis, selective removal of this bacterium from the vaginal microbiome treats or prevents conditions associated with vaginal dysbiosis, such as bacterial vaginosis and its sequelae.Type: GrantFiled: February 26, 2021Date of Patent: February 7, 2023Assignee: Osel, Inc.Inventors: Thomas P. Parks, Trine Nilsen
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Patent number: 11278581Abstract: This invention provides for a method for improving the success rate of in vitro fertilization in women hosting abnormal vaginal microbiota. The method comprises the steps of: (i) selecting a woman suspected of hosting abnormal vaginal microbiota (AVM); (ii) administering to the woman a suitable antibiotic administered in an amount and duration effective to reduce the quantity of abnormal vaginal microbiota hosted by the woman; (iii) administering to the woman via vaginal administration an amount of Lactobacillus species in an amount sufficient to colonize the vaginal mucosa; and, (iv) transferring an embryo to the woman.Type: GrantFiled: July 5, 2018Date of Patent: March 22, 2022Assignee: Osel, Inc.Inventors: Thomas P. Parks, Peter Humaidan, Jørgen Skov Jensen, Niels Uldbjerg, Thor Haahr
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Patent number: 11083761Abstract: This invention provides for a dry preserved formulation of Lactobacillus suitable for administration to people as a pro-biotic or live biotherapeutic treatment where the formulation is stable, has high potency, and contains no animal-derived excipients.Type: GrantFiled: March 20, 2020Date of Patent: August 10, 2021Assignee: Osel, Inc.Inventors: Thomas P. Parks, Angela Marcobal
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Patent number: 8642029Abstract: The present invention relates to methods and compositions for Lactobacillus Replacement Therapy (LRT). Methods for improved stability and recovery of dried bacterial preparations are also provided.Type: GrantFiled: March 30, 2009Date of Patent: February 4, 2014Assignee: Osel, Inc.Inventors: Jun Wang, Yang Liu, Qiang Xu
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Patent number: 8329447Abstract: The invention provides a naturally occurring strain of Lactobacillus crispatus with advantageous characteristics. The strain colonizes mucosal surfaces, particularly vaginal surfaces. The strain is also capable of rapid growth in a number of conditions and is highly viable after desiccation. Moreover, the strain is capable of preventing and reducing pathogenic infection of vaginal mucosa.Type: GrantFiled: December 9, 2009Date of Patent: December 11, 2012Assignee: Osel, Inc.Inventors: Yang Liu, Rosa R. Yu, Andrew Cheng, Qing Xia, Qiang Xu
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Publication number: 20110135615Abstract: The present invention relates to methods and compositions for Lactobacillus Replacement Therapy (LRT). Methods for improved stability and recovery of dried bacterial preparations are also provided.Type: ApplicationFiled: March 30, 2009Publication date: June 9, 2011Applicant: Osel, Inc.Inventors: Jun Wang, Yang Liu, Qiang Xu
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Publication number: 20110066137Abstract: The present invention relates to applicators for applying powders to the vaginal mucosa.Type: ApplicationFiled: December 17, 2008Publication date: March 17, 2011Applicant: OSEL, Inc.Inventors: Thomas Parks, Troy Just
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Patent number: 7833791Abstract: The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.Type: GrantFiled: November 9, 2007Date of Patent: November 16, 2010Assignee: Osel, Inc.Inventors: Chia-Hwa Chang, David A. Simpson, Theresa Li-Yun Chang, Qiang Xu, John A. Lewicki
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Patent number: 7754467Abstract: Methods and compositions for targeting heterologous polypeptides to bacterial cell walls are provided.Type: GrantFiled: January 28, 2004Date of Patent: July 13, 2010Assignee: Osel, Inc.Inventors: Chia-Hwa Chang, Xiaowen Liu, John A. Lewicki, Qiang Xu
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Publication number: 20100151026Abstract: The invention provides a naturally occurring strain of Lactobacillus crispatus with advantageous characteristics. The strain colonizes mucosal surfaces, particularly vaginal surfaces. The strain is also capable of rapid growth in a number of conditions and is highly viable after desiccation. Moreover, the strain is capable of preventing and reducing pathogenic infection of vaginal mucosa.Type: ApplicationFiled: December 9, 2009Publication date: June 17, 2010Applicant: Osel, Inc.Inventors: Yang Liu, Rosa R. Yu, Andrew Cheng, Qing Xia, Qiang Xu
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Publication number: 20090155304Abstract: This disclosure relates to a modified version of cyanovirin-N protein and a transformed Lactobacillus bacterium that is capable of recombinantly expressing this modified protein. Further disclosed are polynucleotide sequence encoding the modified cyanovirin-N protein, expression cassette that allows the expression of the modified protein, and method of make and use of the modified protein as well as the transformed Lactobacillus bacterium. In addition, this disclosure describes two novel promoters originated from L. jensenii, which are capable of directing a high level of gene expression in Lactobacillus bacteria. Also described are an expression cassette comprising one of the novel promoters, a genetically modified Lactobacillus bacterium containing the expression cassette, a method for recombinant gene expression in Lactobacillus bacteria using the novel promoters, and a method for delivery of proteins with desired biological activity to a mucosal surface in a human.Type: ApplicationFiled: November 24, 2008Publication date: June 18, 2009Applicant: Osel, Inc.Inventors: Xiaowen Liu, Kirsten Essenmacher, David A. Simpson, Qiang Xu
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Publication number: 20090148408Abstract: The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.Type: ApplicationFiled: November 9, 2007Publication date: June 11, 2009Applicant: Osel, Inc.Inventors: Chia-Hwa Chang, David A. Simpson, Theresa Li-Yun Chang, Qiang Xu, John A. Lewicki
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Patent number: 7456011Abstract: This disclosure relates to a modified version of cyanovirin-N protein and a transformed Lactobacillus bacterium that is capable of recombinantly expressing this modified protein. Further disclosed are polynucleotide sequence encoding the modified cyanovirin-N protein, expression cassette that allows the expression of the modified protein, and method of make and use of the modified protein as well as the transformed Lactobacillus bacterium. In addition, this disclosure describes two novel promoters originated from L. jensenii, which are capable of directing a high level of gene expression in Lactobacillus bacteria. Also described are an expression cassette comprising one of the novel promoters, a genetically modified Lactobacillus bacterium containing the expression cassette, a method for recombinant gene expression in Lactobacillus bacteria using the novel promoters, and a method for delivery of proteins with desired biological activity to a mucosal surface in a human.Type: GrantFiled: January 12, 2006Date of Patent: November 25, 2008Assignee: Osel, Inc.Inventors: Xiaowen Liu, Kirsten Essenmacher, David A. Simpson, Qiang Xu
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Patent number: 7312076Abstract: The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.Type: GrantFiled: January 5, 2007Date of Patent: December 25, 2007Assignee: Osel, Inc.Inventors: Chia-Hwa Chang, David A. Simpson, Theresa Li-Yun Chang, Qiang Xu, John A. Lewicki
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Publication number: 20070117197Abstract: The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.Type: ApplicationFiled: January 5, 2007Publication date: May 24, 2007Applicant: Osel, Inc.Inventors: Chia-Hwa Chang, David Simpson, Theresa Chang, Qiang Xu, John Lewicki
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Patent number: 7179458Abstract: The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.Type: GrantFiled: March 6, 2003Date of Patent: February 20, 2007Assignee: Osel, Inc.Inventors: Chia-Hwa Chang, David A. Simpson, Theresa Li-Yun Chang, Qiang Xu, John A. Lewicki
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Publication number: 20060194226Abstract: This disclosure relates to a modified version of cyanovirin-N protein and a transformed Lactobacillus bacterium that is capable of recombinantly expressing this modified protein. Further disclosed are polynucleotide sequence encoding the modified cyanovirin-N protein, expression cassette that allows the expression of the modified protein, and method of make and use of the modified protein as well as the transformed Lactobacillus bacterium. In addition, this disclosure describes two novel promoters originated from L. jensenii, which are capable of directing a high level of gene expression in Lactobacillus bacteria. Also described are an expression cassette comprising one of the novel promoters, a genetically modified Lactobacillus bacterium containing the expression cassette, a method for recombinant gene expression in Lactobacillus bacteria using the novel promoters, and a method for delivery of proteins with desired biological activity to a mucosal surface in a human.Type: ApplicationFiled: January 12, 2006Publication date: August 31, 2006Applicant: Osel, Inc.Inventors: Xiaowen Liu, Kirsten Essenmacher, David Simpson, Qiang Xu
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Publication number: 20050003510Abstract: Methods and compositions for targeting heterologous polypeptides to bacterial cell walls are provided.Type: ApplicationFiled: January 28, 2004Publication date: January 6, 2005Applicant: OSEL, INC.Inventors: Chia-Hwa Chang, Xiaowen Liu, John Lewicki, Qiang Xu
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Publication number: 20030228297Abstract: The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.Type: ApplicationFiled: March 6, 2003Publication date: December 11, 2003Applicant: Osel, Inc.Inventors: Chia-Hwa Chang, David A. Simpson, Theresa Li-Yun Chang, Qiang Xu, John A. Lewicki
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Publication number: 20020086020Abstract: This invention relates to methods of increasing the half-life of a viral-specific ligand on a mucosal membrane by modifying the viral-specific ligand to bind the bacteria colonized on the mucosal membrane. The invention also provides a chimeric molecule comprising a viral-specific ligand and a bacterial-specific ligand.Type: ApplicationFiled: January 10, 2002Publication date: July 4, 2002Applicant: OSEL, INC.Inventor: Peter P. Lee