Abstract: The present invention is related to a fusion protein comprising a variant of a nucleoprotein antigen from Influenza strain A, B or C, and a variant of a C4bp oligomerization domain for increasing the cellular immunogenicity of the nucleoprotein antigen from Influenza. The invention is also related to nucleic acids, vectors, fusion proteins and immunogenic compositions, for their use as a vaccine or immunotherapy for the prevention and treatment of influenza disease.
Type:
Grant
Filed:
December 21, 2015
Date of Patent:
May 8, 2018
Assignee:
OSIVAX SAS
Inventors:
Judith Del Campo Ascarateil, Fergal Hill