Patents Assigned to Ospedale San Raffaele S.r.L.
  • Lentiviral vectors carrying synthetic bi-directional promoters and uses thereof
    Patent number: 8501464
    Abstract: It is described a bidirectional promoter for expression of at least two coding sequences in opposite direction in animal cells; bidirectional expression cassettes; expression constructs; gene transfer expression vectors, and methods for the use thereof.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: August 6, 2013
    Assignee: Ospedale San Raffaele S.r.l.
    Inventors: Luigi Naldini, Mario Amendola, Elisa Vigna
  • INCREASE OF MYELOID MICROVESICLES IN THE CEREBROSPINAL FLUID AS BIOMARKER OF MICROGLIA/MACROPHAGE ACTIVATION IN NEUROLOGICAL DISORDERS
    Publication number: 20130040318
    Abstract: The present invention relates to a method for the diagnostic and/or prognostic of a neurological disease characterized by an inflammation process in a subject comprising measuring the amount of myeloid derived microvesicles in a cerebrospinal fluid sample obtained from the subject. The invention further relates to a method for predicting and/or monitoring the efficacy of a treatment for a neurological pathology or for monitoring a neurological disease progression.
    Type: Application
    Filed: March 3, 2011
    Publication date: February 14, 2013
    Applicants: Consiglio Nazionale delle Ricerche, Universita degli Studi Milano, Ospedale San Raffaele S.r.L.
    Inventors: Claudia Verderio, Michela Matteoli, Roberto Furlan