Abstract: The present invention relates to methods of and compositions comprising cytokines for, improving the success rate of embryo implantation and the success rate of pregnancy rates in females, by providing an immunopermissive uterine environment prior to insemination or implantation of embryos. The methods of the present invention are used to make the uterus more receptive or less hostile to, for example, transferred embryos, sperm or other allografted tissue.
Type:
Grant
Filed:
March 22, 2019
Date of Patent:
April 27, 2021
Assignee:
Ostara Biomedical Ltd.
Inventors:
Nadia Gopichandran, Nicolas Michel Orsi, David Andrew Brooke
Abstract: The present invention relates to methods, compositions and kits for controlling, managing or manipulating the non-human mammalian female reproductive cycle. The methods include oestrus induction and/or synchronisation, induction of ovulation and/or superovulation and optionally further includes a method of providing an immunopermissive uterine environment prior to insemination or implantation of embryos.
Type:
Grant
Filed:
October 4, 2016
Date of Patent:
March 17, 2020
Assignee:
Ostara Biomedical Ltd.
Inventors:
Nicolas Michel Orsi, Nadia Gopichandran, David Andrew Brooke
Abstract: The present invention relates to methods of and compositions comprising cytokines for, improving the success rate of embryo implantation and the success rate of pregnancy rates in females, by providing an immunopermissive uterine environment prior to insemination or implantation of embryos. The methods of the present invention are used to make the uterus more receptive or less hostile to, for example, transferred embryos, sperm or other allografted tissue.
Type:
Grant
Filed:
January 27, 2016
Date of Patent:
May 21, 2019
Assignee:
Ostara Biomedical Ltd.
Inventors:
Nadia Gopichandran, Nicolas Michel Orsi, David Andrew Brooke
Abstract: The present invention relates to methods of and compositions comprising cytokines for, improving the success rate of embryo implantation and the success rate of pregnancy rates in females, by providing an immunopermissive uterine environment prior to insemination or implantation of embryos. The methods of the present invention are used to make the uterus more receptive or less hostile to, for example, transferred embryos, sperm or other allografted tissue.
Type:
Grant
Filed:
August 12, 2014
Date of Patent:
December 25, 2018
Assignee:
Ostara Biomedical Ltd.
Inventors:
Nadia Gopichandran, Nicolas Michel Orsi, David Andrew Brooke