Patents Assigned to OsteoScreen
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Publication number: 20130122053Abstract: The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.Type: ApplicationFiled: September 24, 2012Publication date: May 16, 2013Applicants: Trustees of Dartmouth College, Rutgers, The State University of New Jersey, The Regents of the University of California, Osteoscreen, Inc.Inventors: Trustees of Dartmouth College, Osteoscreen, Inc., The Regents of the University of California, Rutgers, The State University of new Jersey
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Patent number: 8299046Abstract: The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.Type: GrantFiled: November 16, 2007Date of Patent: October 30, 2012Assignees: Trustees of Dartmouth College, Osteoscreen, Inc., The Regents of the Universtiy of CaliforniaInventors: Michael B. Sporn, Karen T. Liby, Tadashi Honda, Gregory Mundy, Ross Garrett, Hari Reddi, Gordon W. Gribble, Takahiro Niikura
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Patent number: 7678395Abstract: Flavanoid components of the Ginkgo biloba tree are useful to stimulate the growth of hair and are thus useful in treatment of alopecia or baldness.Type: GrantFiled: November 2, 2004Date of Patent: March 16, 2010Assignee: Osteoscreen, Inc.Inventors: Wolfgang E. Gallwitz, I. Ross Garrett, Gloria Gutierrez
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Publication number: 20090181098Abstract: Methods of enhancing skeletal framework tissue are provided by treating a site requiring enhancement with an HMG-CoA reductase inhibitor at a dosage and for a duration that enhances the tissue while avoiding excess of the inhibitor and degradation of the enhancement.Type: ApplicationFiled: March 6, 2007Publication date: July 16, 2009Applicant: OsteoScreen IP, LLCInventors: Ian R Garrett, Gloria Gutierrez, Gianni Rossini, Samuel P. Sawan, Gregory R. Mundy
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Publication number: 20080233195Abstract: The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34.Type: ApplicationFiled: November 16, 2007Publication date: September 25, 2008Applicants: Trustees of Dartmouth College, Regents of the University of California, Osteoscreen, Inc.Inventors: Michael B. Spoorn, Karen T. Liby, Tadashi Honda, Gordon Gribble, Gregory Mundy, Ross Garrett, Hari Reddi, Takahiro Niikura
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Patent number: 7288535Abstract: The invention relates to compositions and methods for use in treating skeletal system disorders in a vertebrate at risk for bone loss, and in treating conditions that are characterized by the need for bone growth, in treating fractures, and in treating cartilage disorders. More specifically, the invention concerns the use of NO-bisphosphonate assembly for enhancing bone growth.Type: GrantFiled: May 2, 2003Date of Patent: October 30, 2007Assignee: OsteoScreen, Inc.Inventor: I. Ross Garrett
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Publication number: 20070196316Abstract: Flavanoid components of the Ginkgo biloba tree are useful to stimulate the growth of hair and are thus treatment of alopecia or baldness.Type: ApplicationFiled: November 2, 2004Publication date: August 23, 2007Applicant: OSTEOSCREEN, INC.Inventors: Wolfgang Gallwitz, I. Garrett, Gloria Gutierrez
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Patent number: 7223554Abstract: Compounds that inhibit the activity of the proteasome or the production of proteasomal proteins promote hair growth by stimulating the production of hair follicles, and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.Type: GrantFiled: December 30, 2004Date of Patent: May 29, 2007Assignee: Osteoscreen, Ltd.Inventors: I. Ross Garrett, Jorge Gianny Rossini, Gloria Gutierrez
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Patent number: 7175994Abstract: Compounds that inhibit the activity of the proteasome or the production of proteasomal proteins promote hair growth by stimulating the production of hair follicles, and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.Type: GrantFiled: July 19, 2004Date of Patent: February 13, 2007Assignee: Osteoscreen IP, LLCInventors: I. Ross Garrett, Jorge Gianny Rossini, Gloria Gutierrez
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Patent number: 7101907Abstract: The topical administration of statins for the treatment of bone disorders is disclosed.Type: GrantFiled: August 29, 2003Date of Patent: September 5, 2006Assignees: ZymoGenetics Corporation, OsteoScreen IP, LLCInventors: Shirley R. Gasper, Robert R. West, Theresa Martinez, Kirk G. Robbins, Patricia A. McKernan, Nand Baindur, Virender M. Labroo, Gregory R. Mundy
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Patent number: 6958220Abstract: This inventions relates to compounds that inhibit the activity of the proteasome and both promotes hair growth and stimulates the production of hair follicles. The compounds provided herein are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.Type: GrantFiled: January 15, 2002Date of Patent: October 25, 2005Assignee: OsteoScreen, Inc.Inventors: Gregory R. Mundy, I. Ross Garrett, Jorge G. Rossini
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Patent number: 6902721Abstract: The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation, in subject where this is desirable.Type: GrantFiled: October 20, 1999Date of Patent: June 7, 2005Assignee: OsteoScreen, Inc.Inventors: Gregory R. Mundy, I. Ross Garrett, Jorge G. Rossini
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Patent number: 6884769Abstract: Compounds that inhibit the activity of NF-?B or inhibit the activity of the proteasome or both promote bone formation and hair growth and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyrdidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation; they also stimulate the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.Type: GrantFiled: April 25, 2000Date of Patent: April 26, 2005Assignee: OsteoScreen, Inc.Inventors: Gregory R. Mundy, I. Ross Garrett, Jorge Gianny Rossini
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Patent number: 6838252Abstract: The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.Type: GrantFiled: January 15, 2002Date of Patent: January 4, 2005Assignee: OsteoScreen, Inc.Inventors: Gregory R. Mundy, I. Ross Garrett, Jorge Gianny Rossini
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Patent number: 6838436Abstract: The present invention relates to compounds that inhibit the activity of the proteasome or the productions of proteasomal proteins and promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgey, and post-dental implantation, in subject where this is desirable.Type: GrantFiled: October 23, 2000Date of Patent: January 4, 2005Assignee: Osteoscreen Inc.Inventors: Gregory R. Mundy, I. Ross Garrett, Jorge Gianny Rossini
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Publication number: 20040254238Abstract: Methods and compositions provided herein relate to the promotion of bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation. Disclosed is a method of enhancing bone formation by administering at least two components selected from at least one statin-like compound, at least one nitric oxide generating system, and at least one phosphodiesterase inhibitor. Also disclosed is a pharmaceutical composition comprising said at least two components.Type: ApplicationFiled: April 7, 2004Publication date: December 16, 2004Applicant: OSTEOSCREENInventors: I. Ross Garrett, Gregory R. Mundy, Gloria Gutierrez
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Patent number: 6656904Abstract: The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote hair growth and the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.Type: GrantFiled: January 15, 2002Date of Patent: December 2, 2003Assignee: OsteoScreen, Inc.Inventors: Gregory R. Mundy, I. Ross Garrett, Jorge Gianny Rossini
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Patent number: 6649631Abstract: Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.Type: GrantFiled: November 19, 1999Date of Patent: November 18, 2003Assignees: The Board of Regents of the University of Texas System, ZymoGenetics Corporation, OsteoScreenInventors: Mark W. Orme, Nand Baindur, Kirk G. Robbins, Scott M. Harris, Maria Kontoyianni, Laurence H. Hurley, Sean M. Kerwin, Gregory Mundy, Charles Petrie
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Patent number: 6642216Abstract: Compounds of the formula wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6C; Y is of the formula or a stereoisomer thereof, wherein R1 is substituted or unsubstituted alkyl; each R2 is independently H, hydroxy, alkoxy (1-6C) or lower alkyl (1-4C); R3 is H, hydroxy, or alkoxy (1-6C); or Y is of the formula wherein each n is 1, Z is N, K comprises a substituted or unsubstituted aromatic carbocyclic or heterocyclic ring system which may optionally be spaced from the linkage position shown in formula (7) by a linker of 1-2C, or in formula (7), Z may be spaced from the carbon bonded to X by ═CR6— wherein R6 is H or linear, branded or cyclic alkyl (1-6C), R5 is H or linear, branched or cyclic alkyl, and R′ represents a cation, H or a substituted or unsubstituted alkyl group of 1-6C, promote bone formation and are thus useful in treating osteType: GrantFiled: May 3, 2001Date of Patent: November 4, 2003Assignees: ZymoGenetics Corporation, OsteoScreen, Inc.Inventors: Shirley R. Gasper, Robert R. West, Theresa Martinez, Kirk G. Robbins, Patricia A. McKernan, Nand Baindur, Virender M. Labroo, Gregory R. Mundy
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Patent number: 6492333Abstract: The present invention involves the identification and use of compositions for treating myeloma bone disease. The compositions inhibit proteasomal activity and decrease the activity of the transcription factor NF-&kgr;B. Assessment of a candidate compound for its ability to inhibit production or activity of proteasomal enzymes or NF-&kgr;B provides a useful means to identify agents to treat myeloma bone disease.Type: GrantFiled: April 9, 1999Date of Patent: December 10, 2002Assignee: Osteoscreen, Inc.Inventor: Gregory R. Mundy