Patents Assigned to Osteogenex Inc.
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Publication number: 20120301509Abstract: The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.Type: ApplicationFiled: April 25, 2012Publication date: November 29, 2012Applicant: OsteoGeneX, Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20120231010Abstract: The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The compounds include the salts, hydrates and isomers thereof. The present invention also provides methods for the treatment of renal disease and cancer.Type: ApplicationFiled: May 17, 2012Publication date: September 13, 2012Applicant: OsteoGeneX Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20120201815Abstract: The present invention provides a method of promoting local bone growth by administering a therapeutic amount of a Sost antagonist to a mammalian patient in need thereof. Preferably, the Sost antagonist is an antibody or FAB fragment selectively recognizing any one of SEQ ID NOS: 1-23. The Sost antagonist may be coadministered together or sequentially with a matrix conducive to anchoring new bone growth. Orthopedic and Periodontal devices comprising an implantable portion adapted to be permanently implanted within a mammalian body and bearing an external coating of a Sost antagonist are also disclosed, as it a method of increasing bone density by administering to a mammalian patient a therapeutic amount of a Sost antagonist together with an antiresorptive drug.Type: ApplicationFiled: March 15, 2012Publication date: August 9, 2012Applicant: OSTEOGENEX INC.Inventor: Debra L. Ellies
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Patent number: 8198292Abstract: The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The compounds include the salts, hydrates and isomers thereof. The present invention also provides methods for the treatment of renal disease and cancer.Type: GrantFiled: June 30, 2009Date of Patent: June 12, 2012Assignee: Osteogenex, Inc.Inventors: Debra Ellies, William Rosenberg
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Patent number: 8188065Abstract: The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.Type: GrantFiled: October 1, 2009Date of Patent: May 29, 2012Assignee: OsteoGeneX Inc.Inventors: Debra Ellies, William Rosenberg
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Patent number: 8178099Abstract: The present invention provides a method of promoting local bone growth by administering a therapeutic amount of a Sost antagonist to a mammalian patient in need thereof. Preferably, the Sost antagonist is an antibody or FAB fragment selectively recognizing any one of SEQ ID NOS: 1-23. The Sost antagonist may be coadministered together or sequentially with a matrix conducive to anchoring new bone growth. Orthopedic and Periodontal devices comprising an implantable portion adapted to be permanently implanted within a mammalian body and bearing an external coating of a Sost antagonist are also disclosed, as it a method of increasing bone density by administering to a mammalian patient a therapeutic amount of a Sost antagonist together with an antiresorptive drug.Type: GrantFiled: December 21, 2007Date of Patent: May 15, 2012Assignee: OsteoGeneX Inc.Inventor: Debra L. Ellies
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Patent number: 8080575Abstract: The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include compounds of Formula I, wherein each R1 and R2 is H, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkoxy, —OR4, —NR4R5, —SR4, —C(O)R4, —C(O)OR4, —C(O)NR4R5, —N(R4)C(O)R5, —N(R4)C(O)OR5, —N(R4)C(O)NR4R5, —OP(O)(OR4)2, —S(O)2OR4, —S(O)2NR4R5, —CN, cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each R4 and R5 is H or C1-6 alkyl. X is O, S or NR4. Y is an aryl ring system having 6-10 ring members or a heteroaryl ring system having 5-10 ring members where 1-3 ring members are each N, O or S. Subscript n is 1 or 2. The compounds also include salts, hydrates and isomers of the compounds of the present invention.Type: GrantFiled: May 26, 2009Date of Patent: December 20, 2011Assignee: Osteogenex Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20100249171Abstract: The present invention provides a method of reducing body weight in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I: In Formula I, R1 is H, C1-6 alkyl, or C1-6 alkyl-aryl. Each of R2 and R4 of Formula I are independently H, halogen, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkoxy, —OR2a, —SR2a, —C(O)R2a, —C(O)OR2a, —C(O)NR2aR2b, —NR2aR2b, C1-6 alkyl-NR2aR2b, —N(R2a)C(O)R2b, —N(R2a)C(O)OR2b, —N(R2a)C(O)NR2aR2b, —OP(O)(OR2a)2, —S(O)2OR2a, —S(O)2NR2aR2b, —CN, —NO2, cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each of R2a and R2b of Formula I are independently H, C1-6 alkyl, C1-10 heteroalkyl or C1-6 alkyl-aryl. R3 of Formula I is absent, C1-6 alkyl or N-oxide. The compounds include the salts, hydrates and isomers thereof. The present invention also provides methods for the treatment of obesity and disorders related to obesity and higher than recommended percentage body fat, such as type II diabetes.Type: ApplicationFiled: March 15, 2010Publication date: September 30, 2010Applicant: OsteoGeneX Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20100173931Abstract: The present invention provides a method of reducing body weight in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of obesity and disorders related to obesity and higher than recommended percentage body fat, such as type II diabetes.Type: ApplicationFiled: January 5, 2010Publication date: July 8, 2010Applicant: OsteoGeneX Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20100143441Abstract: The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.Type: ApplicationFiled: November 12, 2009Publication date: June 10, 2010Applicant: OsteoGeneX Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20100092559Abstract: The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.Type: ApplicationFiled: October 1, 2009Publication date: April 15, 2010Applicant: OsteoGeneX Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20100074939Abstract: The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.Type: ApplicationFiled: September 18, 2009Publication date: March 25, 2010Applicant: OsteoGeneX Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20100055183Abstract: The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.Type: ApplicationFiled: August 25, 2009Publication date: March 4, 2010Applicant: OsteoGeneX Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20100047314Abstract: The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.Type: ApplicationFiled: August 20, 2009Publication date: February 25, 2010Applicant: OsteoGeneX Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20100040628Abstract: The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.Type: ApplicationFiled: August 11, 2009Publication date: February 18, 2010Applicant: OsteoGeneX, IncInventors: Debra Ellies, William Rosenberg
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Publication number: 20100021524Abstract: The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.Type: ApplicationFiled: July 20, 2009Publication date: January 28, 2010Applicant: OsteoGeneX Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20100003324Abstract: The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The compounds include the salts, hydrates and isomers thereof. The present invention also provides methods for the treatment of renal disease and cancer.Type: ApplicationFiled: June 30, 2009Publication date: January 7, 2010Applicant: OsteoGeneX Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20090297606Abstract: The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include compounds of Formula I, wherein each R1 and R2 is H, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkoxy, —OR4, —NR4R5, —SR4, —C(O)R4, —C(O)OR4, —C(O)NR4R5, —N(R4)C(O)R5, —N(R4)C(O)OR5, —N(R4)C(O)NR4R5, —OP(O)(OR4)2, —S(O)2OR4, —S(O)2NR4R5, —CN, cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each R4 and R5 is H or C1-6 alkyl. X is O, S or NR4. Y is an aryl ring system having 6-10 ring members or a heteroaryl ring system having 5-10 ring members where 1-3 ring members are each N, O or S. Subscript n is 1 or 2. The compounds also include salts, hydrates and isomers of the compounds of the present invention.Type: ApplicationFiled: May 26, 2009Publication date: December 3, 2009Applicant: OsteoGeneX Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20090258052Abstract: The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include the following: wherein R1 and R2 are each H or C1-6 alkyl. X is C1-6 alkylene. R3 is H, —OR4, —OC(O)R4, —OC(O)NR4R5, —OC(O)OR4, —OP(O)(OR4)2 or —OC(O)(CH2)2C(O)OH. R4 and R5 are each independently H or C1-20 alkyl. The compounds also include salts, hydrates and isomers of the compounds.Type: ApplicationFiled: April 14, 2009Publication date: October 15, 2009Applicant: OsteoGeneX Inc.Inventors: Debra Ellies, William Rosenberg
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Publication number: 20080160060Abstract: The present invention provides a method of promoting local bone growth by administering a therapeutic amount of a Sost antagonist to a mammalian patient in need thereof. Preferably, the Sost antagonist is an antibody or FAB fragment selectively recognizing any one of SEQ ID NOS: 1-23. The Sost antagonist may be coadministered together or sequentially with a matrix conducive to anchoring new bone growth. Orthopedic and Periodontal devices comprising an implantable portion adapted to be permanently implanted within a mammalian body and bearing an external coating of a Sost antagonist are also disclosed, as it a method of increasing bone density by administering to a mammalian patient a therapeutic amount of a Sost antagonist together with an antiresorptive drug.Type: ApplicationFiled: December 21, 2007Publication date: July 3, 2008Applicant: OSTEOGENEX INC.Inventor: Debra L. Ellies