Abstract: A composition for bone regeneration includes substantially spherical granules. Each of the spherical granules include an outer shell including magnesium phosphate and nano-sized silica and a bioactive core encapsulated by the outer shell. The granules include macro-pores and micro-pores. The macro-pores are intergranular spaces between adjacent granules, and the micro-pores are intragranular nanopores formed on the outer shell of each of the granules. A method of producing the substantially spherical granules, includes providing a mixture of a biological active powder, magnesium phosphate, and an initiator with a colloidal silica solution; rotating the mixture with dual asymmetric centrifugation for a predetermined amount of time; and drying the resulting material.

Abstract: Described is a method for the production of substantially spherical calcium phosphate particles that involves subjecting a composition comprising calcium phosphate to dual asymmetric centrifugation (DAC). Also described are products of the method.

Abstract: Described is a method for the production of substantially spherical calcium phosphate particles that involves subjecting a composition comprising calcium phosphate to dual asymmetric centrifugation (DAC). Also described are products of the method.