Patents Assigned to Osteotech Inc.
  • Publication number: 20110262515
    Abstract: Fenestrated wound repair scaffolds and methods for forming scaffolds involve dispersing human collagen having a preserved amount of native constituents in solution, depositing the human collagen dispersion in a tray, forming openings in the collagen dispersion and removing the liquid component to form a fenestrated wound repair scaffold. Fenestrated wound repair scaffolds include a network of openings passing linearly through the wound repair scaffold to form channels for cells to pass into so as to form a series of cell formations therein.
    Type: Application
    Filed: April 23, 2010
    Publication date: October 27, 2011
    Applicant: Osteotech, Inc.
    Inventors: Nels Lauritzen, Lawrence A. Shimp, Brent Mitchell
  • Publication number: 20110262541
    Abstract: Foam-formed collagen strands and methods for forming strands involve depositing a dispersed solution of an isolated cleaned, de-fatted, enzymatically-treated (or non-enzyme treated) human-derived collagen product having a preserved amount of its natural constituents into grooves of a grooved plate, and processing the dispersed collagen product to provide a foam-formed collagen strand. Foam-formed collagen strands may be processed into threads having a matrix of reticulated pores to conduct biological materials in and through the strand, the collagen of the collagen strand comprising isolated, enzymatically-treated human derived collagen having a preserved amount of its natural collagen constituents.
    Type: Application
    Filed: April 23, 2010
    Publication date: October 27, 2011
    Applicant: Osteotech, Inc.
    Inventors: Nels Lauritzen, Lawrence A. Shimp, Brent Mitchell
  • Publication number: 20100297082
    Abstract: Present inventions present composites of particles and polymers, as well as methods of making such composite and uses thereof. A low or non-porous composite comprises a plurality of bone particles; and polyurethane components with which the bone particles are combined. Provided composites can be prepared in a one-shot process. Alternatively or additionally, composites can be prepared by compression molding under a high pressure. Before or after implantation, provided composites may be set to form a hardened state of composites that provides mechanical strength and supports the in-growth of cells.
    Type: Application
    Filed: May 19, 2010
    Publication date: November 25, 2010
    Applicants: OSTEOTECH, INC., VANDERBILT UNIVERSITY
    Inventors: Scott A. Guelcher, Jerald E. Dumas, Todd M. Boyce
  • Patent number: 7833245
    Abstract: An implant unit used in surgery has a body made from osteogenic implantable material and including an implant portion and a retaining portion, which is coupled to and extends transversely to the implant portion. The retaining portion is attached to the sidewall of the adjoining vertebral body or mammal bone to prevent displacement of the implant portion relative to the vertebral body or mammal bone and to accelerate fusion therebetween.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: November 16, 2010
    Assignee: Osteotech, Inc.
    Inventors: David R. Kaes, John W. Morris, Lawrence A. Shimp, John Winterbottom, Fred Geisler
  • Patent number: 7833255
    Abstract: A bone fastener for stabilizing bone fragments includes a single or multiple components coupleable with one another and displaceable to a locked position of the bone fastener.
    Type: Grant
    Filed: December 27, 2002
    Date of Patent: November 16, 2010
    Assignee: Osteotech, Inc.
    Inventors: David Chow, Perry Geremakis, Erik O. Martz, Stephen Howard Hochschuler, Daniel E. Rosenthal, Steven Annunziato, Larry C. Johnston
  • Publication number: 20100268232
    Abstract: A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering is suitable for a variety of procedure specific uses. Implantation tools may be provided for placing the covering at a surgical site. Kits may be provided including variously sized or shaped coverings and one or more tools for use in placing the covering.
    Type: Application
    Filed: February 12, 2010
    Publication date: October 21, 2010
    Applicant: Osteotech, Inc.
    Inventors: Randal R. Betz, Scott Boden, Munish Chandra Gupta, Michael F. O'Brien, Harvinder Sandhu, Alexis Shelokov, Georgiana Shelokov, Daryl R. Sybert, Alexander Vaccaro, Guobao Wei, Todd M. Boyce, Robert Cohen, Cristy Richards, Lawrence A. Shimp
  • Publication number: 20100256774
    Abstract: A composition includes bone and collagen, wherein the collagen has been acid treated, and cross-linked via dehydrothermal treatment or by a cross-linking agent (e.g., a citric acid derivative) under a compressive force of at least approximately 40 MPa.
    Type: Application
    Filed: December 12, 2008
    Publication date: October 7, 2010
    Applicant: Osteotech ,Inc.
    Inventors: Sherry Hsiu-Ying Wang, Michael Jaffe, Lawrence A. Shimp, Nels J. Lauritzen, Charles M. Schiff
  • Patent number: 7799076
    Abstract: Methods of repairing a joint formed by at least two bone sections are provided wherein a biocompatible osteogenic band fabricated from an osteogenic biological material such as bone, tendon, ligament and collagen is affixed to two or more bone sections.
    Type: Grant
    Filed: August 18, 2008
    Date of Patent: September 21, 2010
    Assignee: Osteotech, Inc.
    Inventors: Daryl R. Sybert, Lawrence A. Shimp, Todd M. Boyce, John W. Boyle
  • Patent number: 7780708
    Abstract: There is provided an implant retaining device, which has the effect of preventing an intervertebral implant from jutting out of the receiving bed. The implant retaining device generally includes a plate having at least one throughbore to receive a screw, and a screw for securing the plate to the vertebrae. The plate may be dimensioned to cover a portion of the opening of a receiving bed, and thus, need only be secured to a single vertebral body. In an alternate embodiment, the plate may be used during bone fracture correction procedures to prevent a bone screw from backing out of engagement with adjacent bone sections. A method of retaining an intervertebral implant using the device is also provided.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: August 24, 2010
    Assignee: Osteotech, Inc.
    Inventors: John W. Morris, Lawrence A. Shimp, David R. Kaes
  • Patent number: 7726319
    Abstract: A method for dehydrating a monolithic bone intended for implantation is provided. The method serves to conserve at least one of the biomechanical properties of the bone during the dehydration of the bone and its subsequent packaging. Also provided is a monolithic bone for implantation and a method of using the bone for the repair of damaged bone.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: June 1, 2010
    Assignee: Osteotech, Inc.
    Inventor: Todd M. Boyce
  • Patent number: 7726002
    Abstract: A cortical bone implant is formed of two or more planks of bone which are connected with one or more offset pins. The pins may be right circular cylinders inserted into a corresponding offset bore which offset bends the inserted pin. The bending creates compression and tensile loads in the pin which loads creates friction compression forces on the planks connecting them to the pins by friction. The pins may have different shapes to form offset configurations in place of the offset bores for friction attachment to the planks. The implants may be formed of flat or L-shaped planks or bones formed into other shapes including interlocking arrangements. Processes and fixtures are disclosed for forming the pins, planks and implants. Various embodiments of the pins, planks, implants and processes are disclosed.
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: June 1, 2010
    Assignee: Osteotech, Inc.
    Inventors: Lawrence A. Shimp, John M. Winterbottom, David R. Kaes, Todd M. Boyce, Erik O. Martz
  • Patent number: 7662184
    Abstract: A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.
    Type: Grant
    Filed: February 19, 2007
    Date of Patent: February 16, 2010
    Assignee: Osteotech, Inc.
    Inventors: Jean T. Edwards, Lawrence A. Shimp, Michele Diegmann, Todd M. Boyce, Nelson L. Scarborough, James L. Russell
  • Patent number: 7662185
    Abstract: A multipart intervertebral implant is provided which includes an implant portion and an implant extender portion. The implant portion and the implant extender portion can be fastened together using any known fastening means including pins, interlocking structure (e.g., dovetail, tongue and groove, etc.), adhesives, etc. The size of the implant extender portion can be selected during a surgical procedure to provide an implant suitable for a particular intervertebral receiving bed. An intervertebral implant is also provided which may be formed from a multiplicity of implant sections which are fastened together to provide an implant having a desired length. Implants having surface configurations which more closely correspond to the configuration of vertebral endplates are also provided.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: February 16, 2010
    Assignee: Osteotech, Inc.
    Inventors: Arthur A. Alfaro, Lawrence A. Shimp, James L. Russell, John W. Boyle, Erik O. Martz, Daniel E. Rosenthal, John W. Morris
  • Patent number: 7645458
    Abstract: A method is provided for sterilizing and/or deactivating adventitious agent(s) on and/or within a biological material which comprises packaging the biological material, altering the original atmosphere associated with the biological material in order to reduce the level of oxygen to which the biological material is exposed and subjecting the packaged biological material with its altered atmosphere to irradiation.
    Type: Grant
    Filed: July 7, 2003
    Date of Patent: January 12, 2010
    Assignee: Osteotech, Inc.
    Inventor: Lawrence A. Shimp
  • Patent number: 7585461
    Abstract: Bone such as cortical or cancellous bone or connective tissue are centrifuged as a solution is applied to the tissue in a continuous process. The centrifuge creates forces, which cause the flowing solution to penetrate substantially all of the cavities of the tissue. The solution, which may be alcohol, a detergent, an oxidizer, or a surfactant, with or without water, flushes the cavities of the tissue and removes and inactivates viral and bacterial contaminants. In a second embodiment, bone or connective tissue is centrifuged in a batch process to remove contaminants from cavities in the tissue by first spinning the tissue dry and then submerging the tissue in a viral/bacteria cleansing solution and centrifuging the submerged tissue and solution at a sufficiently high speed and radius from the spin axis to create substantially high G forces on the tissue and solution to force the solution into and through the tissue cavities.
    Type: Grant
    Filed: January 28, 2004
    Date of Patent: September 8, 2009
    Assignee: Osteotech, Inc.
    Inventors: Lawrence A. Shimp, Sheldon Dean, Daniel Martins
  • Patent number: 7448264
    Abstract: A non-destructive method for evaluating the strength of cancellous bone includes the steps of performing at least two of the following tests on each cancellous bone of a population of cancellous bones: a manual compression test, an apparent density test, and an appearance test; determining a compressive strength for each cancellous bone based on the two tests performed; comparing the determined compressive strength of each cancellous bone against a predetermined compressive strength requirement; and, eliminating a subset of cancellous bone from the population of cancellous bone, which subset of cancellous bone fails to meet the predetermined compressive strength requirement.
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: November 11, 2008
    Assignee: Osteotech, Inc.
    Inventors: Todd M. Boyce, David R. Kaes, Lawrence A. Shimp, John M. Winterbottom
  • Patent number: 7413576
    Abstract: Methods of repairing a joint formed by at least two bone sections are provided wherein a biocompatible osteogenic band fabricated from an osteogenic biological material such as bone, tendon, ligament and collagen is affixed to two or more bone sections.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: August 19, 2008
    Assignee: Osteotech, Inc.
    Inventors: Daryl R Sybert, Lawrence A. Shimp, Todd M Boyce, John W. Boyle
  • Patent number: 7399739
    Abstract: A flowable vertebral augmentation composition for the treatment and repair of a vertebral body defect, e.g., an osteoporotic condition, contains biocompatible, optionally osteoconductive, support elements that are resistant to deformation or fracture under the normal physiologic loads to which the repair site is subject, the support elements being incorporable into the repair site, at least one osteoinductive susbtance and an amount of biocompatible carrier sufficient to render the augmentation composition flowable, the carrier having the capacity to be cleared from the repair site.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: July 15, 2008
    Assignee: Osteotech, Inc.
    Inventor: Lawrence A. Shimp
  • Patent number: 7357895
    Abstract: A method is provided for sterilizing a bioactive material which comprises contacting the bioactive material with hydrogen gas and while the bioactive material is in contact with hydrogen gas, irradiating the bioactive material with ionizing radiation to sterilize the material.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: April 15, 2008
    Assignee: Osteotech, Inc.
    Inventor: Lawrence A. Shimp
  • Patent number: 7323193
    Abstract: Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: January 29, 2008
    Assignee: Osteotech, Inc.
    Inventors: John Morris, Lawrence A. Shimp, Kenneth C. Petersen, Albert Manrique, David Kaes, Nelson Scarborough, Michael Dowd