Patents Assigned to OTC Biotechnologies, LLC
  • Patent number: 9562900
    Abstract: Specific DNA sequences for binding various foodborne and waterborne pathogens and biotoxins are described. Each of these sequences can function in varying assay and sensor formats with varying degrees of success.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: February 7, 2017
    Assignee: OTC Biotechnologies, LLC
    Inventor: John G. Bruno
  • Patent number: 8975390
    Abstract: Specific DNA ligand sequences for binding various arthropod-borne pathogens including arboviruses, rickettsia and parasites are described. Each of these sequences or their linear, two- and three-dimensional linked sequences can function in varying assay and sensor formats with varying degrees of success. Linkage of the whole or partial DNA sequences (putative binding sites) can be used to enhance specificity and affinity towards complex targets, thereby improving assay selectivity and sensitivity in many instances. In addition, the DNA sequences may bind and neutralize or prevent infection from arthropod-borne viruses, rickettsia and Leishmania or other parasites.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: March 10, 2015
    Assignee: OTC Biotechnologies, LLC
    Inventor: John Bruno
  • Patent number: 8658613
    Abstract: Specific DNA sequences for binding various clinically relevant analytes from the human body are described. Each of these sequences or their linear, two- and three-dimensional linked sequences can function in varying assay and sensor formats with varying degrees of success. Linkage of the whole or partial DNA sequences (putative binding sites) can be used to enhance specificity and affinity towards complex targets, thereby improving assay selectivity and sensitivity in many instances. In addition, a FRET-based quantitative method is described for normalizing analyte data by assessing urine creatinine and urea levels. Finally, a method is described for removing creatinine or urea by size-exclusion chromatography prior to a FRET-based aptamer assay to avoid the denaturing effects of these compounds.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: February 25, 2014
    Assignee: OTC Biotechnologies, LLC
    Inventor: John G. Bruno
  • Patent number: 8648181
    Abstract: Specific DNA ligand sequences for binding various arthropod-borne pathogens including arboviruses, rickettsia and parasites are described. Each of these sequences or their linear, two-and three-dimesional linked sequences can function in varying assay and sensor formats with varying degrees of success. Linkage of the whole or partial DNA sequences (putative binding sites) can be used to enhance specificity and affinity towards complex targets, thereby improving assay selectivity and sensitivity in many instances. In addition, the DNA sequences may bind and neutralize or prevent infection from arthropod-borne viruses, rickettsia and Leishmania or other parasites.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: February 11, 2014
    Assignee: OTC Biotechnologies, LLC
    Inventor: John G. Bruno