Abstract: The invention relates to an image-capturing device for the miniaturized near-field image capture of biological tissue, in particular for the imaging of genetic indicators. The image-capturing device comprises at least one digital image sensor and an objective lens in the form of a rod-shaped gradient index lens (GRIN), which objective lens is coupled to the digital image sensor for image capture. The objective lens is connected to the digital image sensor to from a monolithic, fixed assembly. There is no mechanical separating interface between the objective lens and the digital image sensor by means of which the digital image sensor can be separated from the objective lens by the user. The invention further relates to a system for the miniaturized near-field image capture of biological tissue, said system comprising an image-capturing device of this type and an evaluation device connected to the image-capturing device.

Abstract: The invention relates to a positioning device for positioning a medical instrument relative to a patient, wherein the positioning device has a patient fastening member which is specified to fasten the positioning device to the patient, and has an instrument holder which is specified to hold the medical instrument, wherein the patient fastening member has a patient holding surface for bearing on the patient.

Abstract: The invention relates to a medical imaging system which repeatedly irradiates a capturing area of a patient with a radiation and acquires data from the irradiated area of the patient and generates images from such acquired data, characterized in that the system is arranged for automatic adaptive adjustment of at least one parameter of the system influencing the image quality of the generated images dependent from the position, spatial orientation and/or type of an intervention tool which is introduced into the patient.

Abstract: An accessory kit is provided for interventional procedures using a magnetic resonance imaging scanner. The accessory kit includes a patient support and an electrical connection adapter. The patient support has a first end proximal and a second end distal to the scanner. The distal end is configured to create a space to accommodate a clinician, such as narrowing of the distal end or at least one cutout on a side of the distal end. The electrical connection adapter interfaces with the scanner and a scanner table. The accessory kit is configured so that when the proximal end is extended into the scanner bore, the distal end extends outside the bore. The narrowed width and/or cutout(s) of the exposed distal end and the extended gap between the scanner and scanner table create space on at least one side of the patient support that a clinician may use to access a patient.

Abstract: The present invention relates to a method for protecting surfaces of components against cavitation erosion and components provided with such cavitation protection surfaces, wherein in the surface a plurality of microcavities is provided which entrap gas such as air; the gas, air, entrapped inside the microcavities expands in the vicinity of cavitation bubbles, forming a gas cushion layer that directs cavitation jets away from the surface, thereby protecting the surface against cavitation erosion; the cavitation having a reentrant or double reentrant inlet design with typical T-shape and T-shape profile

Abstract: The invention relates to a method for obtaining brain wave data using a microelectrode array, comprising a plurality of electrodes for electrically measuring brain waves and an integrated optical stimulation unit for stimulating brain regions by means of optical signals, wherein the stimulation unit has one or more electrical light sources, and wherein the method includes stimulating neurons of the brain via optical signals produced by the light sources, recording a response of the neurons to the stimulation via the electrodes, unambiguously assigning the recorded response to individual optical stimulation signals provided by the light source, and determining an unambiguous correlation between the optical stimulation signals and resulting brain waves measured by the electrodes.

Abstract: The invention relates to a guide device (1) for guiding and positioning a biopsy needle (100) at a puncture site (101) on the body of a patient, wherein the guide device (1) has a base (2) and a needle holder (3), on which the biopsy needle (100) is guided along the longitudinal extent of same, wherein the position of the needle holder (3) relative to the base (2) can be changed. The invention proposes that the position of the needle holder (3) relative to the base (2) can be changed in only two degrees of freedom (4, 5), wherein the biopsy needle (100) guided on the needle holder (3) always punctures the same puncture site (101) when the position of the needle holder (3) relative to the base (2) changes.

Abstract: The invention relates to a locomotion aid (1) for people with limited mobility, comprising at least one frame (1?), frame legs (2) which are connected to the frame (V) at a first end (2?) and the second ends (2?) of which are equipped with casters (3), a hip lock or a lumbar lock (8) which is connected to the frame (1?) via a return mechanism (7) and via a mounting (6), and a seat (9) with an integrated brake triggering mechanism, wherein the seat (9) interacts with the hip lock (8), the return mechanism (7), which is in the form of a spring for example, and the mounting (6) when the seat is actuated by the person such that the brake triggering mechanism (5?) can be triggered.

Abstract: The invention relates to a holding device comprising at least one locking unit (2) having at least two sockets (3), wherein the sockets (3) are designed to make it possible for joint heads (5) received in the sockets (3) to each pivot about a pivot axis, as well as to a locking unit, to a tool mount and to an instrument holder for use in magnetic resonance imaging (MRI).

Abstract: The invention relates to an operative assistance system (1) for a magnetic resonance tomograph (I) for displaying an entry point (IX) for an instrument on the surface of a patient (VIII), comprising at least one device (3) having at least one first holder (IV) for accommodating at least one conductor loop (III), and having a second holder (V) for accommodating at least one luminous means (II) for displaying predefinable coordinates of the entry point (IX)).

Abstract: A first plurality of images of a scene may be captured. Each image of the first plurality of images may be captured using a different TET. Based at least on the first plurality of images, a long TET, a short TET, and a TET sequence that includes the long TET and the short TET may be determined. A second plurality of images of the scene may be captured. The images in the second plurality of images may be captured sequentially in an image sequence using a sequence of TETs corresponding to the TET sequence. Based on one or more images in the image sequence, an output image may be constructed.

Abstract: The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production.

Abstract: The invention relates to a layer system composed of a silicon-based carrier having a single-crystal surface and of a heterostructure applied directly to the single-crystal surface of the carrier. The layer system according to the invention is characterized in that the carrier comprises a silicon substrate doped with one or more dopants, wherein the doped portion extends across at least 30% of the thickness of the doped silicon substrate and a concentration of the dopants in the doped portion of the silicon substrate is predetermined such that a corrected limiting concentration GK meets the condition of formula (1): GK = ? m = i n ? ? N dot i 1 + 5 × 10 22 ? ? cm - 3 N dot i ? ? - E A i / 0.

Abstract: The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production.

Abstract: The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production.

Abstract: cFLIP serves as a biomarker for efficacy of treatment with IAP antagonists, including Smac peptidomimetics.

Abstract: The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production.

Abstract: The invention relates to a method for determining the concentration of asymmetric dimethylarginine (ADMA) simultaneously with arginine and with symmetric dimethylarginine (SDMA) in biological samples by means of HPLC-MS-MS. The sample preparation consists exclusively of adding a solution of isotope-labeled internal standards (13C6-arginine and D6-ADMA) and of adding a mixture consisting of acetonitrile/propionic acid/trifluoroacetic acid for precipitating high-molecular proteins, the quantity and composition being realized in such a manner that a bringing of the sample composition in line with the composition of the mobile phase in the HPLC separation is achieved without requiring a derivitization or extraction of the analytes.

Abstract: The invention relates to a method for determining the concentration of asymmetric dimethylarginine (ADMA) simultaneously with arginine and with symmetric dimethylarginine (SDMA) in biological samples by means of HPLC-MS-MS. The sample preparation consists exclusively of adding a solution of isotope-labeled internal standards (13C6-argininc and D6-ADMA) and of adding a mixture consisting of acetonitrile/propionic acid/trifluoroacetic acid for precipitating high-molecular proteins, the quantity and composition being realized in such a manner that a bringing of the sample composition in line with the composition of the mobile phase in the HPLC separation is achieved without requiring a derivitization or extraction of the analytes.