Abstract: Methods and devices for treating patients using high partial pressures of dissolved gas in a liquid. Greater than hyperbaric partial pressures of gas may be dissolved and maintained in the liquid when mixing occurs at ambient pressure. Additional increases in dissolved gas partial pressure may be achieved when the temperature of the liquid is further decreased. The method further includes administering the liquid intravenously via a conventional catheter. Gas exchange occurs due to diffusion upon mixing of the liquid and blood within the vasculature of the patient.

Abstract: Methods and devices for creating a supersaturated liquid solution having dissolved gas with hyperbaric partial pressures and aerosolizing the supersaturated solution via a nebulizer. High partial pressures of the dissolved gas may be maintained before, during, and after the aerosolization process. Thus, the hyperbaric partial pressures may be retained in the aerosol particles even after the particles are exposed to ambient barometric pressure. The aerosolized particles may be inhaled to improve oxygenation and blood flow to the lung or alternatively, the aerosolized particles can be topically applied to accelerate wound healing. Nebulizers may produce aerosol particles in some embodiments have mass median aerodynamic diameters of between about 0.25 and about 5 microns, thereby allowing sufficient deposition in the lung parenchyma, proximal to alveoli.

Abstract: Methods and devices for treating patients using high partial pressures of dissolved gas in a liquid. Greater than hyperbaric partial pressures of gas may be dissolved and maintained in the liquid when mixing occurs at ambient pressure. Additional increases in dissolved gas partial pressure may be achieved when the temperature of the liquid is further decreased. The method further includes administering the liquid intravenously via a conventional catheter. Gas exchange occurs due to diffusion upon mixing of the liquid and blood within the vasculature of the patient.

Abstract: Methods and devices for creating a supersaturated liquid solution having dissolved gas with hyperbaric partial pressures and aerosolizing the supersaturated solution via a nebulizer. High partial pressures of the dissolved gas may be maintained before, during, and after the aerosolization process. Thus, the hyperbaric partial pressures may be retained in the aerosol particles even after the particles are exposed to ambient barometric pressure. The aerosolized particles may be inhaled to improve oxygenation and blood flow to the lung or alternatively, the aerosolized particles can be topically applied to accelerate wound healing. Nebulizers may produce aerosol particles in some embodiments have mass median aerodynamic diameters of between about 0.25 and about 5 microns, thereby allowing sufficient deposition in the lung parenchyma, proximal to alveoli.