Abstract: The invention provides in one aspect a drug delivery device comprising a drug container assembly containing a drug, and a plunger positioned within the container assembly, the drug container assembly having an outlet for dispensing the drug, wherein, in an initial position, the outlet is sealed; a drive mechanism comprising a first stored energy source operable to apply pressure on the plunger or the drug container to pressurise the drug, and a first release mechanism operable to unseal the outlet after the drug has been pressurised.

Abstract: An automatic drug delivery device is described, comprising: a housing (1); a skin sensor element (15) coupled to the housing and movable relative to the housing, wherein the skin sensor element is biased into a front position relative to the housing and is movable to a rear position relative to the housing when the skin sensor element is pressed against an injection site; a needle assembly comprising a hypodermic needle (11), the hypodermic needle extending outside of the housing when the device is in a needle insertion configuration; a drug delivery mechanism comprising a stored energy source (4), within the housing; wherein the drug delivery mechanism is released when the skin sensor element is moved from the front position towards the rear position and wherein the stored energy source is arranged to expand along an axis that is offset from an axis of travel of the needle assembly in use; a needle retraction mechanism configured to withdraw the hypodermic needle into the housing when the needle retraction m

Abstract: The invention provides in one aspect a drug delivery device comprising a drug container assembly containing a drug, and a plunger positioned within the container assembly, the drug container assembly having an outlet for dispensing the drug, wherein, in an initial position, the outlet is sealed; a drive mechanism comprising a first stored energy source operable to apply pressure on the plunger or the drug container to pressurise the drug, and a first release mechanism operable to unseal the outlet after the drug has been pressurised.

Abstract: There is provided drug delivery devices comprising a drug container assembly with a needle and automatic needle insertion and drug delivery mechanisms. Aspects of the devices described include a noise-generation mechanism to indicate the completion of drug delivery, a mechanism for triggering drug delivery following needle insertion, front-end activation of the device and a safety mechanism for covering the needle after use and methods of assembly of the devices.

Abstract: An automatic drug delivery device is described, comprising: a housing (1); a skin sensor element (15) coupled to the housing and movable relative to the housing, wherein the skin sensor element is biased into a front position relative to the housing and is movable to a rear position relative to the housing when the skin sensor element is pressed against an injection site; a needle assembly comprising a hypodermic needle (11), the hypodermic needle extending outside of the housing when the device is in a needle insertion configuration; a drug delivery mechanism comprising a stored energy source (4), within the housing; wherein the drug delivery mechanism is released when the skin sensor element is moved from the front position towards the rear position and wherein the stored energy source is arranged to expand along an axis that is offset from an axis of travel of the needle assembly in use; a needle retraction mechanism configured to withdraw the hypodermic needle into the housing when the needle retraction m

Abstract: The invention provides a syringe for dispensing a drug (1), comprising: a rigid syringe body, —a first container (2), in contact with and enclosing the drug; and a second container (3), enclosing the first container, the second container being less gas permeable than the first container, wherein the second container partially or fully forms the rigid syringe body or is held within the rigid syringe body. The invention preserves the drug but allows the drug to be easily accessed without the need for a user to remove a gas barrier structure as a separate action in addition to the other actions needed to deliver the drug.

Abstract: The invention provides a delivery mechanism for an autoinjector comprising: a first drive member configured to drive a first component in an axial direction; a second drive member configured to drive a second component in an axial direction; and a release mechanism configured to control a sequence of release of the first drive member and the second drive member, wherein the release mechanism is positioned at least partially within the first or second drive member.

Abstract: A pre-filled drug delivery device, comprising a housing, a drug container within the housing and containing a drug; a plunger held within the drug container, movement of the plunger within the drug container being operative to dispense the drug from the drug container through an outlet; and a drive mechanism within the housing including a stored energy source and a plunger rod held in locked position against the stored energy source prior to activation of the device, wherein on activation of the device the stored energy source moves the plunger rod such that the plunger rod moves the plunger within the housing wherein the plunger rod comprises a longitudinal shaft formed from sheet metal, wherein the sheet metal defines a plane, and wherein the sheet metal is deformed so that the longitudinal shaft comprises an out-of-plane engagement surface, the out-of-plane engagement surface configured to engage a retaining surface on the housing or on a component of the drive mechanism, to hold the plunger rod in the loc

Abstract: The invention provides in one aspect a drug delivery device comprising a drug container (16), and a plunger (18) positioned within the container assembly, the drug container assembly having an outlet for dispensing the drug, wherein, in an initial position, the outlet is sealed; a drive mechanism comprising a first stored energy source (42) operable to apply pressure on the plunger or the drug container to pressurize the drug, and a first release mechanism operable to unseal the outlet after the drug has been pressurized.

Abstract: There is provided drug delivery devices including a drug container assembly with a needle and automatic needle insertion and drug delivery mechanisms. Aspects of the devices described include a noise-generation mechanism to indicate the completion of drug delivery, a mechanism for triggering drug delivery following needle insertion, front-end activation of the device and a safety mechanism for covering the needle after use and methods of assembly of the devices.

Abstract: The invention provides a drive mechanism for an autoinjector, configured to be coupled to a drug containing portion to form a complete autoinjector, the drive mechanism comprising: a housing (20); a drive means coupled to the housing, the drive means comprising a resilient member (22); a retaining means coupled to the housing, the retaining means (60) engaging the drive means in a first position to retain the resilient member in a deformed condition, and releasing the drive means in a second position; and a coupling means (24) for coupling with a drug containing portion (10). The drug containing portion retains the drive means in a second deformed condition when the retaining means is in the second position, the drive means storing enough energy in the second deformed condition to drive needle insertion and/or drug delivery.

Abstract: A pre-filled drug delivery device, comprising a housing, a drug container within the housing and containing a drug; a plunger held within the drug container, movement of the plunger within the drug container being operative to dispense the drug from the drug container through an outlet; and a drive mechanism within the housing including a stored energy source and a plunger rod held in locked position against the stored energy source prior to activation of the device, wherein on activation of the device the stored energy source moves the plunger rod such that the plunger rod moves the plunger within the housing wherein the plunger rod comprises a longitudinal shaft formed from sheet metal, wherein the sheet metal defines a plane, and wherein the sheet metal is deformed so that the longitudinal shaft comprises an out-of-plane engagement surface, the out-of-plane engagement surface configured to engage a retaining surface on the housing or on a component of the drive mechanism, to hold the plunger rod in the loc

Abstract: The invention provides a syringe or autoinjector for dispensing a drug comprising a rigid syringe body containing the drug, an oxygen absorbing material, a separating element between the drug and oxygen absorbing material to prevent the drug from contacting the oxygen absorbing material but which allows oxygen to pass from the drug to the oxygen absorbing material, and an oxygen impermeable container enclosing both the drug and the oxygen absorbing material, wherein the oxygen impermeable container partially or fully forms the rigid syringe body or is held within the rigid syringe body.

Abstract: The invention provides a delivery mechanism for an autoinjector comprising: a first drive member configured to drive a first component in an axial direction; a second drive member configured to drive a second component in an axial direction; and a release mechanism configured to control a sequence of release of the first drive member and the second drive member, wherein the release mechanism is positioned at least partially within the first or second drive member.

Abstract: A device for storing and administering drug includes a housing, a sealing element (3) and a separate low friction plunger (4) which is substantially-permeable to gas over time. The sealing element (3) is typically broken to allow delivery of the drug. The housing (2) may be filled with the drug through an opening other than the opening through which the pusher (13) enters the housing to move the plunger so as to expel the drug during administration to a patient.

Abstract: The invention provides a drive mechanism for an autoinjector, configured to be coupled to a drug containing portion to form a complete autoinjector, the drive mechanism comprising: a housing (20); a drive means coupled to the housing, the drive means comprising a resilient member (22); a retaining means coupled to the housing, the retaining means (60) engaging the drive means in a first position to retain the resilient member in a deformed condition, and releasing the drive means in a second position; and a coupling means (24) for coupling with a drug containing portion (10). The drug containing portion retains the drive means in a second deformed condition when the retaining means is in the second position, the drive means storing enough energy in the second deformed condition to drive needle insertion and/or drug delivery.