Abstract: Compounds of Formula (I) wherein R, R.sup.1, R.sup.2 and R.sup.9 are as herein defined, processes for their preparation and transition metal complexes comprising such compounds are disclosed. The complexes may be attached to insoluble supports and are useful as asymetric catalysts.
Type:
Grant
Filed:
March 19, 1999
Date of Patent:
December 19, 2000
Assignee:
Oxford Asymmetry International plc
Inventors:
Mario Eugenio Cosamino Polywka, Edwin Moses, Daniel John Bayston, Anthony David Baxter, Mark Richard Ashton
Abstract: This invention relates to novel compounds of general formula (I) ##STR1## wherein R.sup.1 represents an organic group, R.sup.2 represents a hydrogen atom or an organic group, and the asterisk denotes that the group R.sup.1 is predominantly in the R- or S-configuration such that the compound is in substantially enantiomerically pure form. The compounds are a useful source of chiral nucleophiles, e.g. undergoing stereoselective Michael addition to .alpha.,.beta.-unsaturated carboxylic acid derivatives.
Type:
Grant
Filed:
August 12, 1996
Date of Patent:
March 14, 2000
Assignee:
Oxford Asymmetry International PLC
Inventors:
Stephen Graham Davies, Mario Eugenio Cosamino Polywka, David Roy Fenwick, Frank Reed
Abstract: The present invention relates to the synthesis of chiral amino acids and to novel ferrocene-substituted oxazolidinone derivatives useful in such syntheses.
Type:
Grant
Filed:
April 21, 1997
Date of Patent:
September 1, 1998
Assignee:
Oxford Asymmetry International PLC.
Inventors:
Mario Eugenio Cosamino Polywka, Stephen Graham Davies
Abstract: This invention relates to novel compounds of general formula (I): ##STR1## wherein the two R.sup.1 groups are identical lower alkyl groups or together form a lower alkylene group; R.sup.2 and R.sup.3 are both different and are selected from hydrogen atoms or organic groups; X and X', which may be the same or different, are selected from O, S and NR, where R represents an organic group; and the asterisk denotes that the configurations of R.sup.2 and R.sup.3 are such that the compound (I) is in substantially enantiomerically pure 4R- or 4S-form. The compounds are useful chiral auxiliaries to which a wide range of, for example, acyl groups containing prochiral centers may be readily and reversibly coupled to the 3-position amino group.
Type:
Grant
Filed:
June 24, 1996
Date of Patent:
September 1, 1998
Assignee:
Oxford Asymmetry International plc
Inventors:
Stephen Graham Davies, Mario Eugenio Cosamino Polywka, Hitesh Jayantilal Sanganee