Patents Assigned to OXFORD BIODYNAMICS LIMITED
  • APPLICATION OF EPIGENETIC CHROMSOMAL INTERACTIONS IN CANCER DIAGNOSTICS
    Publication number: 20190338367
    Abstract: The invention provides a method of determining the epigenetic chromosome interactions which are relevant to a prognostic companion epigenetic test for cancer.
    Type: Application
    Filed: November 30, 2017
    Publication date: November 7, 2019
    Applicant: Oxford BioDynamics Limited
    Inventors: Francis Hector GRAND, Aroul Selvam RAMADASS, Alexandre AKOULITCHEV, Ewan HUNTER
  • TYPING METHOD
    Publication number: 20190309367
    Abstract: The invention provides a method of determining the epigenetic chromosome interactions which are relevant to an epigenetic test for a neurodegenerative condition.
    Type: Application
    Filed: June 19, 2019
    Publication date: October 10, 2019
    Applicant: Oxford BioDynamics Limited
    Inventors: Aroul Selvam RAMADASS, Ewan HUNTER, Alexandre AKOULITCHEV
  • DETECTION PROCESSES USING SITES OF CHROMOSOME INTERACTION
    Publication number: 20180274015
    Abstract: A process for analysing epigenetically active regions of the genome.
    Type: Application
    Filed: June 24, 2016
    Publication date: September 27, 2018
    Applicant: Oxford Biodynamics Limited
    Inventors: Alexandre Akoulitchev, Ewan Hunter, Aroul Ramadass
  • METHODS OF DETECTING LONG RANGE CHROMOSOMAL INTERACTIONS
    Publication number: 20140162271
    Abstract: The present invention relates to a method of monitoring epigenetic changes comprising monitoring changes in conditional long range chromosomal interactions at at least one chromosomal locus where the spectrum of long range interaction is associated with a specific physiological condition, the method comprising the steps of:— (i) in vitro crosslinking of said long range chromosomal interactions present at the at least one chromosomal locus; (ii) isolating the cross linked DNA from said chromosomal locus; (iii) subjecting said cross linked DNA to restriction digestion with an enzyme that cuts at least once within the at least one chromosomal locus; (iv) ligating said cross linked cleaved DNA ends to form DNA loops; (v) identifying the presence of said DNA loops; wherein the presence of DNA loops indicates the presence of a specific long range chromosomal interaction.
    Type: Application
    Filed: June 20, 2013
    Publication date: June 12, 2014
    Applicant: Oxford Biodynamics Limited
    Inventors: Aroul Selvam Ramadass, Alexandre Akoulitchev, Elizabeth Jane Mellor
  • METHODS OF DETECTING LONG RANGE CHROMOSOMAL INTERACTIONS
    Publication number: 20110098342
    Abstract: The present invention relates to a method of monitoring epigenetic changes comprising monitoring changes in conditional long range chromosomal interactions at at least one chromosomal locus where the spectrum of long range interaction is associated with a specific physiological condition, the method comprising the steps of: —(i) in vitro crosslinking of said long range chromosomal interactions present at the at least one chromosomal locus; (ii) isolating the cross linked DNA from said chromosomal locus; (iii) subjecting said cross linked DNA to restriction digestion with an enzyme that cuts at least once within the at least one chromosomal locus; (iv) ligating said cross linked cleaved DNA ends to form DNA loops; (v) identifying the presence of said DNA loops; wherein the presence of DNA loops indicates the presence of a specific long range chromosomal interaction.
    Type: Application
    Filed: June 2, 2009
    Publication date: April 28, 2011
    Applicant: OXFORD BIODYNAMICS LIMITED
    Inventors: Aroul Selvam Ramadass, Alexandre Akoulitchev, Elizabeth Jane Mellor