Abstract: The use of an ScFv Ab (ScFv Ab) capable of recognising a disease associated molecule (DAM) in the manufacture of a medicament for the prevention and/or treatment of a disease condition associated with a DAM is described. The ScFv Ab has therapeutic, diagnostic and prognostic applications.
Type:
Grant
Filed:
November 2, 2001
Date of Patent:
July 11, 2006
Assignee:
Oxford Biomedica PLC
Inventors:
Susan Mary Kingsman, Christopher Robert Bebbington, Miles William Carrol, Fiona Margaret Ellard, Kevin Alan Myers
Abstract: Retroviral vector production systems for producing lentivirus-based vector particles which are capable of infecting and transducing non-dividing target cells, wherein one or more of the auxiliary genes such as vpr, vif, tat, and nef in the case of HIV-1 are absent from the system. The systems and resulting retrovirus vector particles have improved safety over existing systems and vectors.
Type:
Grant
Filed:
December 28, 1998
Date of Patent:
November 6, 2001
Assignee:
Oxford BioMedica plc
Inventors:
Alan John Kingsman, Susan Mary Kingsman, Narry Kim, Kyriacos Mitrophanous