Patents Assigned to Oxford Gene Systems Limited
  • Vector expressing fusion proteins and particles
    Patent number: 5041385
    Abstract: Fusion proteins comprising a first amino acid sequence and a second amino acid sequence are disclosed. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion protein the ability to assemble into particles. The TYA gene of the yeast retrotransposon Ty codes for the first amino acid sequence. The second amino acid sequence is a biologically active antigen. The particles formed by the fusion proteins are useful in vaccines or in diagnostic or purification applications.
    Type: Grant
    Filed: April 10, 1987
    Date of Patent: August 20, 1991
    Assignee: Oxford Gene Systems Limited
    Inventors: Alan J. Kingsman, Susan M. Kingsman, Sally E. Adams, Michael H. Malim, Elizabeth-Jane C. Mellor
  • Fusion proteins and particles
    Patent number: 5008373
    Abstract: Fusion proteins comprise a first amino acid sequence and a second amino acid sequence. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion protein the ability of assemble into particles; an example is the product of the TYA gene of the yeast retrotransposon Ty. The second amino acid sequence is biologically active; for example, it may be antigenic.
    Type: Grant
    Filed: October 26, 1987
    Date of Patent: April 16, 1991
    Assignee: Oxford Gene Systems Limited
    Inventors: Alan J. Kingsman, Susan M. Kingsman, Sally E. Adams, Elizabeth J. C. Mellor, Michael H. Malim
  • Particulate hybrid HIV antigens
    Patent number: 4918166
    Abstract: Fusion proteins comprise a77 first amino acid sequence and a second amino acid sequence. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion protein the ability to assemble into particles; an example is the product of the YTA gene of the yeast retrotransposon Ty. The second amino acid sequence is an HIV antigen. So particles formed of the fusion proteins may be useful in vaccines or in diagnostic or purification applications.
    Type: Grant
    Filed: October 26, 1987
    Date of Patent: April 17, 1990
    Assignee: Oxford Gene Systems Limited
    Inventors: Alan J. Kingsman, Susan M. Kingsman, Sally E. Adams