Patents Assigned to Oxis International S.A.
  • Use of novel organoselenium compounds as pro-oxidizing agents, their methods of preparation and pharmaceutical compositions and application thereof
    Patent number: 6130212
    Abstract: Compounds represented by the following formula I: ##STR1## in which: R.sup.1 to R.sup.5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR.sup.6 R.sup.7).sub.n in which n=0 or 1, and CO are disclosed. These compounds are useful as anti-tumor drugs, especially with pro-oxidizing activity.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: October 10, 2000
    Assignee: Oxis International S.A.
    Inventors: Jinzhu Xu, Georges Appere, Jean Chaudiere, Jean-Claude Yadan
  • Aromatic diselenides and selenosulfides, their preparation and their uses, more particularly their therapeutical use
    Patent number: 6040328
    Abstract: The objects of the present invention are:novel organoselenium compounds: aromatic diselenides and selenosulphides;the use of said novel compounds as antioxidant agents;pharmaceutical compositions containing them;a method of preparation of said novel compounds.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: March 21, 2000
    Assignee: Oxis International S.A.
    Inventors: Catherine Tailhan-Lomont, Irene Erdelmeier, Marc Moutet, Jean Chaudiere, Jean-Claude Yadan
  • Aromatic diselenides and selenosulfides, their preparation and their uses, more particularly their therapeutical use
    Patent number: 5973009
    Abstract: The objects of the present invention are:novel organoselenium compounds: aromatic diselenides and selenosulphides;the use of said novel compounds as antioxidant agents;pharmaceutical compositions containing them;a method of preparation of said novel compounds.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: October 26, 1999
    Assignee: Oxis International S.A.
    Inventors: Catherine Tailhan-Lomont, Irene Erdelmeier, Marc Moutet, Jean Chaudiere, Jean-Claude Yadan
  • Spectrophotometric methods for assaying total mercaptans, reduced glutathione (GSH) and mercaptans other than GSH in an aqueous medium reagents and kits for implementing same
    Patent number: 5817520
    Abstract: According to the invention, the total mercaptans in an aqueous sample are assayed by means of the formation of a chromophoric substitution product between all the mercaptans present in the sample and a reagent corresponding to the general formula I: ##STR1## Reduced glutathione (GSH) is assayed in the form of a chromophoric thione formed specifically by alkalization from the substitution product formed above between GSH and the reagent.The concentration of mercaptans distinct from GSH is obtained by subtraction of the concentrations obtained in the preceding assays.Application to the assay of mercaptans and GSH, especially in the presence of other mercaptans, in particular in biological media.
    Type: Grant
    Filed: August 12, 1996
    Date of Patent: October 6, 1998
    Assignee: Oxis International S.A.
    Inventors: Jean-Claude Yomtob Yadan, Marc Gabriel Antoine, Jean Raymond Chaudiere
  • Method for assaying the sod activity by using a self-oxidizable compound necessary for its implementation, self-oxidizable compounds and preparation thereof
    Patent number: 5543298
    Abstract: The method for assaying the SOD (super oxide dismutase) activity in liquid medium is based on the activation of self-oxidization, by SOD activity, of a reactive agent having the general formula (I) wherein either n is 1 or 2, R.sup.1 is --OR.sup.4 or --NR.sup.5 R.sup.6 ; R.sup.2 is H, --OR.sup.4, alkyl (1-6C), --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --, to form a ring by binding to the phenyl substituent, at meta with respect to R.sup.1 ; and R.sup.3 is H, alkyl (1-6C) or --OR.sup.4 (if R.sup.2 is different from --OR.sup.4); with R.sup.4 being H or alkyl (1-6C); R.sup.5 being H, alkyl (1-6C), --CH.sub.2 COOH, --C.sub.6 H.sub.5 COOH or --C.sub.6 H.sub.5 SO.sub.3 H; and R.sup.6 is H, alkyl (1-6C) or --CH.sub.2 COOH; or n is 1, R.sup.1 is --OR.sup.4, R.sup.2 is --CH.sub.2 --O--, in order to form a ring by bonding of O with the phenyl substituent, at meta with respect to R.sup.1 ; and R.sup.3 is H or --OR.sup.4.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: August 6, 1996
    Assignee: Oxis International S.A.
    Inventors: Jinzhu Xu, Jean-Claude Y. Yadan, Marc E. Moutet, Jean R. Chaudiere