Abstract: Disclosed are a spiro-bisphosphorous compound, and a preparation and application thereof. The spiro-bisphosphorous compound is expressed in formula (I), (II) or (III).

Abstract: A saddle having a laser projection direction-indicating device is provided. The laser projection direction-indicating device has a module housing mounted to a saddle body. A left laser element is disposed in a left laser projection port of the module housing; a right laser element is disposed in a right laser projection port of the module housing. A control unit is connected with the left laser element and the right laser element. A direction signal generation unit is connected with the control unit and generates a left turn signal or a right turn signal to the control unit. The laser projection direction-indicating device responds to the left turn signal or the right turn signal generated by the direction signal generation unit to have the control unit drive the left laser element or the right laser element to generate a laser projection pattern.

Abstract: Method of treating hyperglycemia induced Red Blood Cell Disease/Dysfunction (RBCD) caused by generation of early and late glycation end products. Method of treating hemolytic anemia, smoldering hemolytic anemia, sickle cell anemia, hemorrhagic diseases, hemorrhagic stroke, hemorrhagic bleeding. Method of treating RBCD to prevent progression to diabetes associated vascular complications referred to as Syndrome X, particularly to prevent progression to chronic kidney disease, coronary vascular disease, and peripheral vascular disease.

Abstract: A clamp assembly for attaching a grip to a bike handlebar is provided. The clamp assembly includes an insertion member that is inserted between the grip and the bike handlebar and has an outer end formed with a jaw structure. A clamping member is disposed into and coupled with the jaw structure. The clamping member is of a C-shaped structure having a first end and a second end that face and correspond to each other and spaced by a spacing distance. With the clamping member being disposed into and coupled with the jaw structure of the insertion member, a fastening member is applied to reduce and shrink the spacing distance between the first end and the second end of the clamping member.

Abstract: The disclosure relates to chemical synthesis, and more particularly to a biphenyltetradentate phosphite compound and a preparation and application thereof.

Abstract: A knife gate valve including a knife valve gate, a gate actuation mechanism, operatively connected to the knife valve gate, a two-part sleeve and a valve body. The two-part sleeve includes an upstream section and a downstream section with the knife valve gate being selectively insertable therebetween. The valve body includes an upper casing section and a lower casing section pivotally connected to one another. The upper casing section and the lower casing section each include a concave cavity together defining a sleeve receiving channel of the valve body. The two-part sleeve is removably engageable in the sleeve receiving channel. The upper casing section and the lower casing section are pivotable between an operative configuration preventing removal of the two-part sleeve from the sleeve receiving channel and a maintenance configuration allowing insertion and removal of the two-part sleeve from the sleeve receiving channel.

Abstract: A knife gate valve including a knife valve gate, a gate actuation mechanism, operatively connected to the knife valve gate, a two-part sleeve and a valve body. The two-part sleeve includes an upstream section and a downstream section with the knife valve gate being selectively insertable therebetween. The valve body includes an upper casing section and a lower casing section pivotally connected to one another. The upper casing section and the lower casing section each include a concave cavity together defining a sleeve receiving channel of the valve body. The two-part sleeve is removably engageable in the sleeve receiving channel. The upper casing section and the lower casing section are pivotable between an operative configuration preventing removal of the two-part sleeve from the sleeve receiving channel and a maintenance configuration allowing insertion and removal of the two-part sleeve from the sleeve receiving channel.

Abstract: Method of treating hyperglycemia induced Red Blood Cell Disease/Dysfunction (RBCD) caused by generation of early and late glycation end products. Method of treating hemolytic anemia, smoldering hemolytic anemia, sickle cell anemia, hemorrhagic diseases, hemorrhagic stroke, hemorrhagic bleeding. Method of treating RBCD to prevent progression to diabetes associated vascular complications referred to as Syndrome X, particularly to prevent progression to chronic kidney disease, coronary vascular disease, and peripheral vascular disease.

Abstract: A tissue anchor (200, 258, 300) includes a shaft (122), a tissue-coupling element (128), and a flexible elongate tension member (202). The tissue-coupling element (128) includes a wire (150), which is shaped as an open loop (154) having more than one turn when the tissue anchor (200, 258, 300) is unconstrained. The tension member (202) includes a distal portion (204) that is fixed to a site (206) on the open loop (154), a proximal portion (208), which has a longitudinal segment (209) that runs alongside at least a portion (210) of the shaft (122), and a crossing portion (212), which (i) is disposed between the distal and the proximal N portions (204, 208) along the tension member (202), and (ii) crosses at least a portion of the open loop (154) when the tissue anchor (200, 258, 300) is unconstrained.

Abstract: The invention relates to an interactive system (S) for a device including a control unit (UCd), means for releasing multimedia content (Md), with the control unit (UCd) cooperating with said means for providing the control thereof. To enhance the attractiveness of the device, the system (S) comprises a processing unit (UC), at least one tag (T1, T2, Ti, Tn) to be affixed to said means for releasing (Md). Said at least one tag is directly connected to the processing unit and further enables a wireless communication (CP) with a communicating object (Oc). The processing unit (UC) is so arranged as to communicate with the control unit (UCd) in order to trigger an action relative to the multimedia content released in response to a communication initiated by said at least one tag.

Abstract: The present disclosure relates to a pinch valve having upper and lower casings respectively supporting upper and lower pinch elements. The upper and lower casings are adapted for receiving a sleeve. A synchronization mechanism drives movements of the upper and lower pinch elements for pinching the sleeve. The upper and lower casings are connected by a pivot allowing pivoting of one or the other of the upper and lower casings for opening of the pinch valve, and for ease of access to the sleeve for maintenance purposes.

Abstract: Interactive system for a device releasing multimedia content, associated device and methods. The invention relates to an interactive system (S) for a device including a control unit (UCd), means for releasing multimedia content (Md), with the control unit (UCd) cooperating with said means for providing the control thereof. To enhance the attractiveness of the device, the system (S) comprises a processing unit (UC), at least one tag (T1, T2, Ti, Tn) to be affixed to said means for releasing (Md). Said at least one tag is directly connected to the processing unit and further enables a wireless communication (CP) with a communicating object (Oc). The processing unit (UC) is so arranged as to communicate with the control unit (UCd) in order to trigger an action relative to the multimedia content released in response to a communication initiated by said at least one tag.

Abstract: Methods of using a stabilized chlorite solution to inhibit antigen-specific immune responses are disclosed. The stabilized chlorite solution, when administered to a mammal in need thereof, can prevent the presentation of antigens by antigen presenting cells. The stabilized chlorite solution therefore is useful in treating, inter alia, auto-immune diseases, treating diseases caused by an inappropriate immune response, treating lymphoproliferative disease and in inhibiting rejection in transplant patients.

Abstract: Methods of determining clinical outcomes in patients suffering from a pathological condition or syndrome are provided. Levels of intracellular gene expression re measured from a clinical sample provided by the patient, and the levels are compared to reference levels. Deviations from reference levels are predictive of clinical outcomes, for example, disease progression or response to therapeutic intervention.

Abstract: Methods of determining clinical outcomes in patients suffering from a pathological condition or syndrome are provided. Levels of intracellular gene expression re measured from a clinical sample provided by the patient, and the levels are compared to reference levels. Deviations from reference levels are predictive of clinical outcomes, for example, disease progression or response to therapeutic intervention.

Abstract: The present invention is concerned with the use of a chemically-stabilized chlorite matrix for the parenteral treatment of HIV infections. The chlorite matrix is an isotonic solution containing 5 to 100 mMol ClO.sub.2- per liter of solution.

Abstract: The present invention relates to a process for the preparation of diols of the general formula (I) ##STR1## and monoesters thereof of the general formula (II) ##STR2## and the general formula (III) ##STR3## wherein R.sub.1 and R.sub.2 are the same of different groups and each denotes a lower alkyl group having 1 to 4 carbon atoms, preferably a methyl group. The process of this invention comprises condensing in a multi-phase reaction environment an aldehyde containing a hydrogen atom in the alpha position and having the general formula (IV) ##STR4## wherein R.sub.1 and R.sub.2 having the meaning given above, in the presence of a catalytic system consisting of a phase transferring catalyst and an alkaline substance.

Abstract: A universal handle for household and other hand-held implements, the handle being adapted to ergonomically render the implement to which it is applied useable by individuals who have diffculty in firmly grasping a conventional handle. The universal handle, which is fabricated of elastomeric material having good thermal isulation and cushioning properties, includes an internal cavity to socket the core shank of the implement. The handle has an ellipticl cross section, the opposing sides of the handle adjacent its upper end each having a concave depression, in each of which an array of spaced, flexible fins is anchored to define a depressible grip site. When the fingers of a user's hand are clenched about the handle, the internal region of the resultant fist conforms to the form of the handle to provide a good grip thereon, the thumb and forefinger pressing into the grip sites to enhance the user's grip on the handle.