Patents Assigned to Oxular Limited
  • Patent number: 11622884
    Abstract: The present invention provides a cannulation device for administering an active agent containing composition to the suprachoroidal space or supraciliary space. The invention provides methods of treatment of an ocular disease or condition accordingly. The invention also provides compositions for use in a method of treatment of an ocular disease or condition for delivery into the suprachoroidal space or supraciliary space.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: April 11, 2023
    Assignee: Oxular Limited
    Inventors: Robert Steven Bley, Stanley R. Conston, Ronald Yamamoto
  • Patent number: 11564834
    Abstract: The present invention provides a drug composition comprising particles comprising a biodegradable or bioerodable polymer and a drug, a soluble, biodegradable or bioerodible excipient, a bulking agent and a reconstitution aid. The invention also provides a pharmaceutical formulation and a unit dosage form of the pharmaceutical formulation. The invention provides methods of treatment of a disease or condition accordingly. The invention also provides a drug composition for use in a cannulation device.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: January 31, 2023
    Assignee: Oxular Limited
    Inventors: Robert Steven Bley, Stanley R. Conston, Ronald K. Yamamoto, Tien T. Nguyen, John P. Lunsford, Dillon Daniel Martinez, Loc X. Phan
  • Patent number: 11154420
    Abstract: A device for controlled delivery of an injection material to tissue spaces of an eye that are not normally open, such as the subconjunctival space, the suprachoroidal space and the subretinal space. The device comprises an elongated body with a hollow cannula at the distal end, a slidable plunger at the proximal end, and a reservoir for the material to be injected residing between the cannula and the plunger. The plunger is mechanically coupled to a source of force such as a spring or pressurized gas reservoir such that an injection force is applied to the injection material within the device prior to delivery of the injection material into an eye. A valve that is normally closed to prevent flow of the injection material during application of the injection force is placed in the flow path between the cannula and reservoir. Due to the injection force placed on the injection material, actuation of the valve allows controlled flow from the reservoir through the cannula and into the tissue space.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: October 26, 2021
    Assignee: Oxular Limited
    Inventors: Ronald K. Yamamoto, Stanley R. Conston, Robert Steven Bley
  • Patent number: 11096822
    Abstract: Injection device comprising an elongated body (1) with a hollow needle (8) at a distal end; a reservoir for an injection material to be delivered through the needle; a plunger (3) with a first force element (5) configured to provide an injection force to said injection material, and a distal element (10) attached to the distal end of the device thereby sealing a needle lumen, wherein the distal element comprises a tissue interface and a distal seal (11), and wherein the distal seal is penetrable by a distal tip of the needle by the application of pressure on a tissue surface with the distal end of the device, wherein the penetrated distal element becomes slidable on the needle to allow advancement of the needle into tissue, wherein the penetrated distal seal opens a path for flow or delivery of the injection material from the distal end of the needle.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: August 24, 2021
    Assignee: Oxular Limited
    Inventors: Ronald K. Yamamoto, Stanley R. Conston