Abstract: Vitamin C compositions comprise a Vitamin C compound, preferably a mineral ascorbate, and at least one compound of the group of 4-hydroxy-5-methyl-3(2H)-furanone and 3-hydroxy kojic acid.

Abstract: The effect of cancer chemotherapeutic agents is potentiated by combination with mineral ascorbates, Vitamin C metabolites and/or Vitamin C-derived furanones.

Abstract: Liquid vitamin C concentrate compositions comprise a mineral ascorbate and a pharmacologically acceptable liquid organic polyol solvent for the mineral ascorbate, the concentrate having a pH between about 5 and 7. The concentrate may also contain an aldonic compound and/or a pharmacologically acceptable zinc compound. The concentrate compositions are prepared by heating the solvent to 50-90° C. and mixing the ascorbate and/or aldonic compound and/or zinc compound into the heated solvent, preferably in the absence of oxygen. These concentrate compositions are also characterized as a composition which comprises the reaction product of a mineral ascorbate and a pharmacologically acceptable liquid organic polyol solvent and, optionally an aldonic compound and/or a soluble non-toxic zinc compound, which reaction product includes 4-hydroxy-5-methyl-3(2H)-furanone and/or 3-hydroxy kojic acid.

Abstract: A composition useful for administering therapeutically active compounds to improve the body absorption and/or retention thereof comprising a composition includes a therapeutically active compound having a molecular weight below about 5,000, having an acidic functional group and a pKa of .ltoreq.6 at pH 7.4 normally eliminated unmetabolized from the body via the renal tubular secretion pathway for organic anions, for example, Vitamin C, and at least one compound selected from the class consisting of L-threonic, L-xylonic and L-lyxonic acids, and the edible salts, aldono-lactones and aldono-lactides thereof.A method for establishing and maintaining body levels of a therapeutically active compound includes the step of administering a therapeutically effective dose of this composition.

Abstract: A composition useful for administering therapeutically active compounds to improve the body absorption and/or retention thereof comprising a composition which includes a therapeutically active compound having a molecular weight below about 5,000 and having an acidic functional group, which is normally eliminated from the body via the renal tubular secretion pathway for organic anions, for example, Vitamin C, and at least one compound selected from the class consisting of L-threonic, L-xylonic and L-lyxonic acids, and the edible salts, aldono-lactones and aldono-lactides thereof.A method for establishing and maintaining body levels of a therapeutically active compound which includes the step of administering a therapeutically effective dose of this composition.

Abstract: A composition useful for administering Vitamin C to a subject comprises a compound having Vitamin C activity and at least one compound selected from the class consisting of the aldono-lactones and edible salts of L-threonic, L-xylonic and L-lyxonic acids.High Vitamin C levels in the human body are established by orally administering to a human subject an effective amount of this composition.