Patents Assigned to Oxygenix Co., Ltd.
  • Publication number: 20120034466
    Abstract: A thin film polymer structure obtained by the steps of: (a) causing polyfunctional molecules to adsorb to an area of an arbitrary shape in an interface between a substrate body and a liquid phase; (b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film; and (c) exfoliating the formed thin film from the substrate body.
    Type: Application
    Filed: August 31, 2005
    Publication date: February 9, 2012
    Applicants: Oxygenix Co., Ltd., Shinji TAKEOKA, WASEDA UNIVERSITY
    Inventors: Shinji Takeoka, Yosuke Okamura, Masanori Ohtsuka
  • Publication number: 20080247949
    Abstract: The present invention relates to a biological tissue examination agent comprising hemoglobin labeled with 15O2 and a method for producing the same. More specifically, the present invention relates to a biological tissue examination agent for diagnosing a cause or condition of a disease by detecting oxygen metabolism in a biological tissue using hemoglobin labeled with 15O2, and a method for producing the same. The present invention also relates to a method for detecting oxygen metabolism in a biological tissue.
    Type: Application
    Filed: November 18, 2005
    Publication date: October 9, 2008
    Applicant: Oxygenix Co., Ltd.
    Inventors: Yasuhisa Fujibashi, Tetsuya Mori, Makoto Suematsu, Katsuji Ohta
  • Publication number: 20070123698
    Abstract: The present invention provides a method for purifying hemoglobin from red blood cells, wherein the red blood cells are deep-frozen and preserved, and then purified.
    Type: Application
    Filed: December 27, 2004
    Publication date: May 31, 2007
    Applicants: OXYGENIX CO., LTD., WASEDA UNIVERSITY
    Inventors: Eishun Tsuchida, Shinji Takeoka, Keitaro Sou
  • Publication number: 20070003483
    Abstract: The present invention provides a method of analyzing organ or tissue injury, comprising the following steps of: (a) labeling the organ or tissue with dye; (b) obtaining multiple indices involving xenobiotic metabolism and/or cell condition of said organ or tissue; and (c) analyzing the organ or tissue injury from said indices.
    Type: Application
    Filed: September 28, 2004
    Publication date: January 4, 2007
    Applicant: Oxygenix Co., Ltd.
    Inventor: Makoto Suematsu
  • Publication number: 20060088583
    Abstract: The present invention provides an agent containing L-tyrosine that prevents methemoglobin formation, and a vesicle comprising the above agent for preventing methemoglobin formation. More specifically, the present invention provides an oxygen infusion preparation suitable for long-term storage, which prevents an increase in methemoglobin content as a result of oxidation of hemoglobin or the like encapsulated in an vesicle having a lipid bilayer membrane structure.
    Type: Application
    Filed: July 12, 2005
    Publication date: April 27, 2006
    Applicants: Oxygenix Co., Ltd., Waseda University
    Inventors: Shinji Takeoka, Eishun Tsuchida, Hiromi Sakai, Yuji Teramura, Tomoyasu Atoji
  • Patent number: 6967020
    Abstract: An oxygen carrier system includes an artificial oxygen carrier including hemoglobin vesicles encapsulating hemoglobin and an intermediate electron mediator having a standard electrode potential of 0.05 V to 0.56 V (vs. the standard hydrogen electrode) in the vesicles, and a reducing agent which is added to an external aqueous phase of the hemoglobin vesicle to reduce methemoglobin when the hemoglobin encapsulated in the hemoglobin vesicle is oxidized to the methemoglobin. The reducing agent has, as an active component, at least one compound selected from the group consisting of a thiol compound and a reducing sugar.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: November 22, 2005
    Assignee: Oxygenix Co., Ltd
    Inventors: Eishun Tsuchida, Shinji Takeoka, Yuji Teramura, Tomoyasu Atoji
  • Patent number: 6965049
    Abstract: Provided is a zwitterionic lipid compound represented by formula (I) given below: In formula (I), m and n are independently integers of 1 to 4, p is an integer of 7 to 21, one R is NH3+, and each other R is H.
    Type: Grant
    Filed: February 23, 2004
    Date of Patent: November 15, 2005
    Assignee: Oxygenix Co., Ltd.
    Inventors: Eishun Tsuchida, Shinji Takeoka, Keitaro Sou, Katsura Mori
  • Publication number: 20050025757
    Abstract: An oxygen carrier system includes an artificial oxygen carrier including hemoglobin vesicles encapsulating hemoglobin and an intermediate electron mediator having a standard electrode potential of 0.05 V to 0.56 V (vs. the standard hydrogen electrode) in the vesicles, and a reducing agent which is added to an external aqueous phase of the hemoglobin vesicle to reduce methemoglobin when the hemoglobin encapsulated in the hemoglobin vesicle is oxidized to the methemoglobin. The reducing agent has, as an active component, at least one compound selected from the group consisting of a thiol compound and a reducing sugar.
    Type: Application
    Filed: August 27, 2004
    Publication date: February 3, 2005
    Applicant: OXYGENIX CO., LTD.
    Inventors: Eishun Tsuchida, Shinji Takeoka, Yuji Teramura, Tomoyasu Atoji
  • Publication number: 20040162261
    Abstract: Provided is a zwitterionic lipid compound represented by formula (I) given below: 1
    Type: Application
    Filed: February 23, 2004
    Publication date: August 19, 2004
    Applicant: OXYGENIX CO., LTD.
    Inventors: Eishun Tsuchida, Shinji Takeoka, Keitaro Sou, Katsura Mori