Abstract: A thin film polymer structure obtained by the steps of: (a) causing polyfunctional molecules to adsorb to an area of an arbitrary shape in an interface between a substrate body and a liquid phase; (b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film; and (c) exfoliating the formed thin film from the substrate body.
Type:
Application
Filed:
August 31, 2005
Publication date:
February 9, 2012
Applicants:
Oxygenix Co., Ltd., Shinji TAKEOKA, WASEDA UNIVERSITY
Abstract: The present invention relates to a biological tissue examination agent comprising hemoglobin labeled with 15O2 and a method for producing the same. More specifically, the present invention relates to a biological tissue examination agent for diagnosing a cause or condition of a disease by detecting oxygen metabolism in a biological tissue using hemoglobin labeled with 15O2, and a method for producing the same. The present invention also relates to a method for detecting oxygen metabolism in a biological tissue.
Abstract: The present invention provides a method for purifying hemoglobin from red blood cells, wherein the red blood cells are deep-frozen and preserved, and then purified.
Type:
Application
Filed:
December 27, 2004
Publication date:
May 31, 2007
Applicants:
OXYGENIX CO., LTD., WASEDA UNIVERSITY
Inventors:
Eishun Tsuchida, Shinji Takeoka, Keitaro Sou
Abstract: The present invention provides a method of analyzing organ or tissue injury, comprising the following steps of: (a) labeling the organ or tissue with dye; (b) obtaining multiple indices involving xenobiotic metabolism and/or cell condition of said organ or tissue; and (c) analyzing the organ or tissue injury from said indices.
Abstract: The present invention provides an agent containing L-tyrosine that prevents methemoglobin formation, and a vesicle comprising the above agent for preventing methemoglobin formation. More specifically, the present invention provides an oxygen infusion preparation suitable for long-term storage, which prevents an increase in methemoglobin content as a result of oxidation of hemoglobin or the like encapsulated in an vesicle having a lipid bilayer membrane structure.
Abstract: An oxygen carrier system includes an artificial oxygen carrier including hemoglobin vesicles encapsulating hemoglobin and an intermediate electron mediator having a standard electrode potential of 0.05 V to 0.56 V (vs. the standard hydrogen electrode) in the vesicles, and a reducing agent which is added to an external aqueous phase of the hemoglobin vesicle to reduce methemoglobin when the hemoglobin encapsulated in the hemoglobin vesicle is oxidized to the methemoglobin. The reducing agent has, as an active component, at least one compound selected from the group consisting of a thiol compound and a reducing sugar.
Abstract: Provided is a zwitterionic lipid compound represented by formula (I) given below: In formula (I), m and n are independently integers of 1 to 4, p is an integer of 7 to 21, one R is NH3+, and each other R is H.
Type:
Grant
Filed:
February 23, 2004
Date of Patent:
November 15, 2005
Assignee:
Oxygenix Co., Ltd.
Inventors:
Eishun Tsuchida, Shinji Takeoka, Keitaro Sou, Katsura Mori
Abstract: An oxygen carrier system includes an artificial oxygen carrier including hemoglobin vesicles encapsulating hemoglobin and an intermediate electron mediator having a standard electrode potential of 0.05 V to 0.56 V (vs. the standard hydrogen electrode) in the vesicles, and a reducing agent which is added to an external aqueous phase of the hemoglobin vesicle to reduce methemoglobin when the hemoglobin encapsulated in the hemoglobin vesicle is oxidized to the methemoglobin. The reducing agent has, as an active component, at least one compound selected from the group consisting of a thiol compound and a reducing sugar.