Patents Assigned to Oxyrase, Inc.
  • Patent number: 11771722
    Abstract: Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments and anaerobe bacteria is injected into a tumor to interfere with tumor growth and metabolism, leading to tumor necrosis. The composition may also contain a cryoprotectant, which permits the composition to be stored at sub-zero temperatures without freezing.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: October 3, 2023
    Assignee: Oxyrase, Inc.
    Inventor: James C. Copeland
  • Patent number: 11286450
    Abstract: A culture system includes a dish and a lid. The dish comprises a base, a sidewall extending from the base, and a track extending outwardly from an outer surface of the sidewall. The lid comprises a central horizontal wall and a recess formed by two sidewalls and a top wall. At least one key extends downwardly from the recess. The sidewall of the dish extends into the recess of the lid, and the key engages the track. The track is shaped so that the lid rises or falls relative to the base of the dish when the lid is rotated relative to the dish.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: March 29, 2022
    Assignee: Oxyrase, Inc.
    Inventors: James C. Copeland, John E. Richey
  • Patent number: 11207386
    Abstract: Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments is administered within a tumor to create a hypoxic environment. This interferes with tumor growth and metabolism, and can lead to tumor death.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: December 28, 2021
    Assignee: Oxyrase, Inc.
    Inventor: James C. Copeland
  • Patent number: 10722543
    Abstract: Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments and anaerobe bacteria is injected into a tumor to interfere with tumor growth and metabolism, leading to tumor necrosis. The composition may also contain a cryoprotectant, which permits the composition to be stored at sub-zero temperatures without freezing.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: July 28, 2020
    Assignee: Oxyrase, Inc.
    Inventor: James C. Copeland
  • Patent number: 10611996
    Abstract: Methods of preserving and storing biological specimens, particularly anaerobe microorganisms are disclosed. A composition containing oxygen scavenging membrane fragments and a cryoprotectant is administered to the specimens. The specimens are then stored at a temperature that is lower than 0° C. and greater than ?70° C. Cryogenic freezing is not required.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: April 7, 2020
    Assignee: OXYRASE, INC.
    Inventor: James C. Copeland
  • Patent number: 10076556
    Abstract: Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments is administered within a tumor to create a hypoxic environment. This interferes with tumor growth and metabolism, and can lead to tumor death.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: September 18, 2018
    Assignee: OXYRASE, INC.
    Inventor: James C. Copeland
  • Patent number: 7374905
    Abstract: The present invention is directed to a medium, broth or agar, and a method of utilizing the same, in order to isolate and/or identify anaerobes from a mixed sample that contains facultative microorganisms. The medium contains an inhibitor of the electron transport system, such as a salt of azide (N3?), cyanide (CN?) or related compounds. These inhibitors are present in an amount sufficient to limit the growth of facultative microorganisms under anaerobic conditions while not inhibiting the growth of the anaerobe microorganisms. Preferably, the inhibitor is present in the amount of from about 0.1 mg/ml to about 1.0 mg/ml in broth medium, and from about 0.01 mg/ml to 1.0 mg/ml in agar medium.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: May 20, 2008
    Assignee: Oxyrase, Inc.
    Inventors: James C. Copeland, Kathy J. Myers
  • Publication number: 20030104608
    Abstract: The present invention is directed to a novel method, composition and device for removing dissolved oxygen from solutions containing alcohols and/or acids. By removing oxygen from various products, the present invention is an effective antioxidant for beverages and food products, as well as for industrial and commercial solutions containing alcohols and/or acids.
    Type: Application
    Filed: March 9, 1993
    Publication date: June 5, 2003
    Applicant: Oxyrase, Inc.
    Inventors: JAMES C. COPELAND, HOWARD I. ADLER, WELDON D. CROW
  • Patent number: 6429008
    Abstract: An apparatus for growing anaerobic microorganisms is provided having a dish top that contains a sealing ring upon which the media surface in the dish bottom rests when the apparatus is inverted. The contact between the sealing ring and the media surface forms a seal that traps the gas in the headspace between the media surface and the inside of the dish top. A oxygen reducing agent can also be incorporated into the media together, in some instances, with a substrate which react with oxygen in the media and with oxygen in the headspace thereby creating an environment suitable for growing anaerobic, microaerophilic and facultative anaerobic microorganisms.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: August 6, 2002
    Assignee: Oxyrase, Inc.
    Inventors: James C. Copeland, Howard I. Adler, Gerald E. Spady
  • Publication number: 20020045245
    Abstract: An apparatus for growing anaerobic microorganisms is provided having a dish top that contains a sealing ring upon which the media surface in the dish bottom rests when the apparatus is inverted. The contact between the sealing ring and the media surface forms a seal that traps the gas in the headspace between the media surface and the inside of the dish top. A oxygen reducing agent can also be incorporated into the media together, in some instances, with a substrate which react with oxygen in the media and with oxygen in the headspace thereby creating an environment suitable for growing anaerobic, microaerophilic and facultative anaerobic microorganisms.
    Type: Application
    Filed: March 19, 2001
    Publication date: April 18, 2002
    Applicant: Oxyrase, Inc.
    Inventors: James C. Copeland, Howard I. Adler, Gerald E. Spady
  • Patent number: 6204051
    Abstract: An apparatus for growing anaerobic microorganisms is provided having a dish top that contains a sealing ring upon which the media surface in the dish bottom rests when the apparatus is inverted. The contact between the sealing ring and the media surface forms a seal that traps the gas in the headspace between the media surface and the inside of the dish top. A oxygen reducing agent can also be incorporated into the media together, in some instances, with a substrate which react with oxygen in the media and with oxygen in the headspace thereby creating an environment suitable for growing anaerobic, microaerophilic and facultative anaerobic microorganisms.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: March 20, 2001
    Assignee: Oxyrase, Inc.
    Inventors: James C. Copeland, Howard I. Adler, Gerald E. Spady
  • Patent number: 5955344
    Abstract: An apparatus for growing anaerobic microorganisms is provided having a dish top that contains a sealing ring upon which the media surface in the dish bottom rests when the apparatus is inverted. The contact between the sealing ring and the media surface forms a seal that traps the gas in the headspace between the media surface and the inside of the dish top. A oxygen reducing agent can also be incorporated into the media together, in some instances, with a substrate which react with oxygen in the media and with oxygen in the headspace thereby creating an environment suitable for growing anaerobic, microaerophilic and facultative anaerobic microorganisms.
    Type: Grant
    Filed: November 3, 1997
    Date of Patent: September 21, 1999
    Assignee: Oxyrase, Inc.
    Inventors: James C. Copeland, Howard I. Adler, Gerald E. Spady
  • Patent number: 5830746
    Abstract: An apparatus for growing anaerobic microorganisms is provided having a dish top that contains a sealing ring upon which the media surface in the dish bottom rests when the apparatus is inverted. The contact between the sealing ring and the media surface forms a seal that traps the gas in the headspace between the media surface and the inside of the dish top. A oxygen reducing agent can also be incorporated into the media together, in some instances, with a substrate which react with oxygen in the media and with oxygen in the headspace thereby creating an environment suitable for growing anaerobic, microaerophilic and facultative anaerobic microorganisms.
    Type: Grant
    Filed: May 4, 1994
    Date of Patent: November 3, 1998
    Assignee: Oxyrase, Inc.
    Inventors: James C. Copeland, Howard I. Adler, Gerald E. Spady
  • Patent number: 5482860
    Abstract: The present invention is directed to an apparatus for removing oxygen from a fluid stream. The apparatus is comprised of a flow through reactor chamber containing a sufficient amount of oxygen scavenging cell membrane fragments to catalyze the transformation of oxygen present in a fluid stream to water. The fragments are contained in the apparatus in a manner which allows free contact between the fragments and the fluid stream flowing therethrough or for the diffusion of the oxygen from the fluid stream across a synthetic membrane to a compartment containing the fragments where the oxygen is transformed to water. An inlet for introducing a fluid stream containing oxygen into said flow-through reaction chamber and an outlet for removing the deoxygenated fluid stream are also provided.
    Type: Grant
    Filed: April 20, 1993
    Date of Patent: January 9, 1996
    Assignee: Oxyrase, Inc.
    Inventors: James C. Copeland, Howard I. Adler
  • Patent number: 5432083
    Abstract: The present invention is directed to a novel method and device for removing oxygen from oils. The oils may be in liquid form, such as vegetables oils, etc., in solid form, such as fats, etc. or in some type of intermediate semi-solid form. By removing oxygen from various products containing oils and fats, the present invention is an effective antioxidant for food products, as well as for various industrial and commercial products, such as paints, varnishes, etc. The method comprises the steps of providing an oil containing oxygen and adding to the oil a sufficient amount of an aqueous solution containing oxygen scavenging membrane fragments and a hydrogen donor substance to reduce the oxygen present in the oil to water.
    Type: Grant
    Filed: February 19, 1993
    Date of Patent: July 11, 1995
    Assignee: Oxyrase, Inc.
    Inventors: James C. Copeland, Howard I. Adler
  • Patent number: 5362501
    Abstract: The present invention is directed to a novel method, composition and device for removing dissolved oxygen from solutions containing alcohols and/or acids. By removing oxygen from various products, the present invention is an effective antioxidant for beverages and food products, as well as for industrial and commercial solutions containing alcohols and/or acids.
    Type: Grant
    Filed: February 11, 1991
    Date of Patent: November 8, 1994
    Assignee: Oxyrase, Inc.
    Inventors: James C. Gopeland, Howard I. Adler, Weldon D. Crow
  • Patent number: 5240853
    Abstract: The present invention is directed to a continuous flow method for removing oxygen from a fluid stream. The method comprises the steps of providing a fluid stream containing oxygen, causing the fluid stream to come in contact directly or indirectly, with a sufficient amount of oxygen scavenging cell membrane fragments having an electron transport system which reduces oxygen to water to catalyze the transformation of the oxygen contained in the fluid stream to water. The present invention is also directed to an apparatus for removing oxygen from a fluid stream.
    Type: Grant
    Filed: March 7, 1989
    Date of Patent: August 31, 1993
    Assignee: Oxyrase, Inc.
    Inventors: James C. Copeland, Howard I. Adler
  • Patent number: 4996073
    Abstract: The present invention is directed to a novel method, composition and device for removing dissolved oxygen from solutions containing alcohols and/or acids. By removing oxygen from various products, the present invention is an effective antioxidant for beverages and food products, as well as for industrial and commercial solutions containing alcohols and/or acids.
    Type: Grant
    Filed: August 29, 1989
    Date of Patent: February 26, 1991
    Assignee: Oxyrase, Inc.
    Inventors: James C. Copeland, Howard I. Adler, Weldon D. Crow
  • Patent number: D563560
    Type: Grant
    Filed: March 12, 2007
    Date of Patent: March 4, 2008
    Assignee: Oxyrase, Inc.
    Inventor: James C. Copeland