Patents Assigned to Oxyrase, Inc.
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Patent number: 11771722Abstract: Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments and anaerobe bacteria is injected into a tumor to interfere with tumor growth and metabolism, leading to tumor necrosis. The composition may also contain a cryoprotectant, which permits the composition to be stored at sub-zero temperatures without freezing.Type: GrantFiled: July 27, 2020Date of Patent: October 3, 2023Assignee: Oxyrase, Inc.Inventor: James C. Copeland
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Patent number: 11286450Abstract: A culture system includes a dish and a lid. The dish comprises a base, a sidewall extending from the base, and a track extending outwardly from an outer surface of the sidewall. The lid comprises a central horizontal wall and a recess formed by two sidewalls and a top wall. At least one key extends downwardly from the recess. The sidewall of the dish extends into the recess of the lid, and the key engages the track. The track is shaped so that the lid rises or falls relative to the base of the dish when the lid is rotated relative to the dish.Type: GrantFiled: August 29, 2019Date of Patent: March 29, 2022Assignee: Oxyrase, Inc.Inventors: James C. Copeland, John E. Richey
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Patent number: 11207386Abstract: Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments is administered within a tumor to create a hypoxic environment. This interferes with tumor growth and metabolism, and can lead to tumor death.Type: GrantFiled: September 12, 2018Date of Patent: December 28, 2021Assignee: Oxyrase, Inc.Inventor: James C. Copeland
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Patent number: 10722543Abstract: Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments and anaerobe bacteria is injected into a tumor to interfere with tumor growth and metabolism, leading to tumor necrosis. The composition may also contain a cryoprotectant, which permits the composition to be stored at sub-zero temperatures without freezing.Type: GrantFiled: January 26, 2017Date of Patent: July 28, 2020Assignee: Oxyrase, Inc.Inventor: James C. Copeland
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Patent number: 10611996Abstract: Methods of preserving and storing biological specimens, particularly anaerobe microorganisms are disclosed. A composition containing oxygen scavenging membrane fragments and a cryoprotectant is administered to the specimens. The specimens are then stored at a temperature that is lower than 0° C. and greater than ?70° C. Cryogenic freezing is not required.Type: GrantFiled: January 26, 2017Date of Patent: April 7, 2020Assignee: OXYRASE, INC.Inventor: James C. Copeland
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Patent number: 10076556Abstract: Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments is administered within a tumor to create a hypoxic environment. This interferes with tumor growth and metabolism, and can lead to tumor death.Type: GrantFiled: January 28, 2016Date of Patent: September 18, 2018Assignee: OXYRASE, INC.Inventor: James C. Copeland
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Patent number: 7374905Abstract: The present invention is directed to a medium, broth or agar, and a method of utilizing the same, in order to isolate and/or identify anaerobes from a mixed sample that contains facultative microorganisms. The medium contains an inhibitor of the electron transport system, such as a salt of azide (N3?), cyanide (CN?) or related compounds. These inhibitors are present in an amount sufficient to limit the growth of facultative microorganisms under anaerobic conditions while not inhibiting the growth of the anaerobe microorganisms. Preferably, the inhibitor is present in the amount of from about 0.1 mg/ml to about 1.0 mg/ml in broth medium, and from about 0.01 mg/ml to 1.0 mg/ml in agar medium.Type: GrantFiled: November 8, 2001Date of Patent: May 20, 2008Assignee: Oxyrase, Inc.Inventors: James C. Copeland, Kathy J. Myers
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Publication number: 20030104608Abstract: The present invention is directed to a novel method, composition and device for removing dissolved oxygen from solutions containing alcohols and/or acids. By removing oxygen from various products, the present invention is an effective antioxidant for beverages and food products, as well as for industrial and commercial solutions containing alcohols and/or acids.Type: ApplicationFiled: March 9, 1993Publication date: June 5, 2003Applicant: Oxyrase, Inc.Inventors: JAMES C. COPELAND, HOWARD I. ADLER, WELDON D. CROW
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Patent number: 6429008Abstract: An apparatus for growing anaerobic microorganisms is provided having a dish top that contains a sealing ring upon which the media surface in the dish bottom rests when the apparatus is inverted. The contact between the sealing ring and the media surface forms a seal that traps the gas in the headspace between the media surface and the inside of the dish top. A oxygen reducing agent can also be incorporated into the media together, in some instances, with a substrate which react with oxygen in the media and with oxygen in the headspace thereby creating an environment suitable for growing anaerobic, microaerophilic and facultative anaerobic microorganisms.Type: GrantFiled: March 19, 2001Date of Patent: August 6, 2002Assignee: Oxyrase, Inc.Inventors: James C. Copeland, Howard I. Adler, Gerald E. Spady
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Publication number: 20020045245Abstract: An apparatus for growing anaerobic microorganisms is provided having a dish top that contains a sealing ring upon which the media surface in the dish bottom rests when the apparatus is inverted. The contact between the sealing ring and the media surface forms a seal that traps the gas in the headspace between the media surface and the inside of the dish top. A oxygen reducing agent can also be incorporated into the media together, in some instances, with a substrate which react with oxygen in the media and with oxygen in the headspace thereby creating an environment suitable for growing anaerobic, microaerophilic and facultative anaerobic microorganisms.Type: ApplicationFiled: March 19, 2001Publication date: April 18, 2002Applicant: Oxyrase, Inc.Inventors: James C. Copeland, Howard I. Adler, Gerald E. Spady
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Patent number: 6204051Abstract: An apparatus for growing anaerobic microorganisms is provided having a dish top that contains a sealing ring upon which the media surface in the dish bottom rests when the apparatus is inverted. The contact between the sealing ring and the media surface forms a seal that traps the gas in the headspace between the media surface and the inside of the dish top. A oxygen reducing agent can also be incorporated into the media together, in some instances, with a substrate which react with oxygen in the media and with oxygen in the headspace thereby creating an environment suitable for growing anaerobic, microaerophilic and facultative anaerobic microorganisms.Type: GrantFiled: May 28, 1999Date of Patent: March 20, 2001Assignee: Oxyrase, Inc.Inventors: James C. Copeland, Howard I. Adler, Gerald E. Spady
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Patent number: 5955344Abstract: An apparatus for growing anaerobic microorganisms is provided having a dish top that contains a sealing ring upon which the media surface in the dish bottom rests when the apparatus is inverted. The contact between the sealing ring and the media surface forms a seal that traps the gas in the headspace between the media surface and the inside of the dish top. A oxygen reducing agent can also be incorporated into the media together, in some instances, with a substrate which react with oxygen in the media and with oxygen in the headspace thereby creating an environment suitable for growing anaerobic, microaerophilic and facultative anaerobic microorganisms.Type: GrantFiled: November 3, 1997Date of Patent: September 21, 1999Assignee: Oxyrase, Inc.Inventors: James C. Copeland, Howard I. Adler, Gerald E. Spady
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Patent number: 5830746Abstract: An apparatus for growing anaerobic microorganisms is provided having a dish top that contains a sealing ring upon which the media surface in the dish bottom rests when the apparatus is inverted. The contact between the sealing ring and the media surface forms a seal that traps the gas in the headspace between the media surface and the inside of the dish top. A oxygen reducing agent can also be incorporated into the media together, in some instances, with a substrate which react with oxygen in the media and with oxygen in the headspace thereby creating an environment suitable for growing anaerobic, microaerophilic and facultative anaerobic microorganisms.Type: GrantFiled: May 4, 1994Date of Patent: November 3, 1998Assignee: Oxyrase, Inc.Inventors: James C. Copeland, Howard I. Adler, Gerald E. Spady
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Patent number: 5482860Abstract: The present invention is directed to an apparatus for removing oxygen from a fluid stream. The apparatus is comprised of a flow through reactor chamber containing a sufficient amount of oxygen scavenging cell membrane fragments to catalyze the transformation of oxygen present in a fluid stream to water. The fragments are contained in the apparatus in a manner which allows free contact between the fragments and the fluid stream flowing therethrough or for the diffusion of the oxygen from the fluid stream across a synthetic membrane to a compartment containing the fragments where the oxygen is transformed to water. An inlet for introducing a fluid stream containing oxygen into said flow-through reaction chamber and an outlet for removing the deoxygenated fluid stream are also provided.Type: GrantFiled: April 20, 1993Date of Patent: January 9, 1996Assignee: Oxyrase, Inc.Inventors: James C. Copeland, Howard I. Adler
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Patent number: 5432083Abstract: The present invention is directed to a novel method and device for removing oxygen from oils. The oils may be in liquid form, such as vegetables oils, etc., in solid form, such as fats, etc. or in some type of intermediate semi-solid form. By removing oxygen from various products containing oils and fats, the present invention is an effective antioxidant for food products, as well as for various industrial and commercial products, such as paints, varnishes, etc. The method comprises the steps of providing an oil containing oxygen and adding to the oil a sufficient amount of an aqueous solution containing oxygen scavenging membrane fragments and a hydrogen donor substance to reduce the oxygen present in the oil to water.Type: GrantFiled: February 19, 1993Date of Patent: July 11, 1995Assignee: Oxyrase, Inc.Inventors: James C. Copeland, Howard I. Adler
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Patent number: 5362501Abstract: The present invention is directed to a novel method, composition and device for removing dissolved oxygen from solutions containing alcohols and/or acids. By removing oxygen from various products, the present invention is an effective antioxidant for beverages and food products, as well as for industrial and commercial solutions containing alcohols and/or acids.Type: GrantFiled: February 11, 1991Date of Patent: November 8, 1994Assignee: Oxyrase, Inc.Inventors: James C. Gopeland, Howard I. Adler, Weldon D. Crow
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Patent number: 5240853Abstract: The present invention is directed to a continuous flow method for removing oxygen from a fluid stream. The method comprises the steps of providing a fluid stream containing oxygen, causing the fluid stream to come in contact directly or indirectly, with a sufficient amount of oxygen scavenging cell membrane fragments having an electron transport system which reduces oxygen to water to catalyze the transformation of the oxygen contained in the fluid stream to water. The present invention is also directed to an apparatus for removing oxygen from a fluid stream.Type: GrantFiled: March 7, 1989Date of Patent: August 31, 1993Assignee: Oxyrase, Inc.Inventors: James C. Copeland, Howard I. Adler
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Patent number: 4996073Abstract: The present invention is directed to a novel method, composition and device for removing dissolved oxygen from solutions containing alcohols and/or acids. By removing oxygen from various products, the present invention is an effective antioxidant for beverages and food products, as well as for industrial and commercial solutions containing alcohols and/or acids.Type: GrantFiled: August 29, 1989Date of Patent: February 26, 1991Assignee: Oxyrase, Inc.Inventors: James C. Copeland, Howard I. Adler, Weldon D. Crow
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Patent number: D563560Type: GrantFiled: March 12, 2007Date of Patent: March 4, 2008Assignee: Oxyrase, Inc.Inventor: James C. Copeland