Abstract: Methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided. More particularly, this disclosure relates to methods and apparatuses for providing the models and employing the models for predicting risk of prostate cancer and/or predicting prostate gland volume. The methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided using, at least in part, information from a panel of kallikrein markers.
Type:
Application
Filed:
February 27, 2017
Publication date:
June 15, 2017
Applicants:
OPKO Diagnostics, LLC, Oy Arctic Partners Ab
Inventors:
Andrew J. Vickers, Peter T. Scardino, Hans Lilja, Vincent Linder, David Steinmiller
Abstract: Methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided. More particularly, this disclosure relates to methods and apparatuses for providing the models and employing the models for predicting risk of prostate cancer and/or predicting prostate gland volume. The methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided using, at least in part, information from a panel of kallikrein markers.
Type:
Grant
Filed:
March 5, 2013
Date of Patent:
June 6, 2017
Assignees:
OPKO Diagnostics, LLC, Oy Arctic Partners Ab
Inventors:
Andrew J. Vickers, Peter T. Scardino, Hans Lilja, Vincent Linder, David Steinmiller
Abstract: A bioassay employing a first group including a lanthanide ion carrier chelate and a first recognition element, a second group including an antenna ligand and a second recognition element; where the lanthanide ion carrier chelate binds strongly to lanthanide, or the lanthanide ion carrier chelate binds moderately to lanthanide, and an agent complexing the lanthanide ion is additionally employed at a concentration of at least 1 pmol/l. The antenna ligand binds weakly to the lanthanide ion. Analyte recognition by the first recognition element and by the second recognition element results in either chelate complementation and increased fluorescence, or chelate discomplementation and decreased fluorescence.