Abstract: The invention relates to pharmacology and medicine, and more specifically to slow-release antitumor drug composition based on biodegradable poly(lactic-co-glycolic acid) (PLGA). The composition comprises temozolomide (TMZ) as the active ingredient and comprises, in addition, surface-active material and a cryoprotectant as parts of nanoparticles.
Type:
Application
Filed:
December 10, 2013
Publication date:
November 19, 2015
Applicants:
UNICHEMPHARM LTD, OY FILANA LTD
Inventors:
Ekaterina VASILENKO, Evgeny VORONTSOV, Evgenij SEVERIN, Victor GULENKO, Maxim MITROKHIN, Maksim IURCHENKO
Abstract: The present invention relates to the field of pharmacology and medicine, specifically to a new generation of anticancer drugs with the cytostatic action based on docetaxel. In the drug composition of the invention docetaxel is included in biodigestible stable nanoparticles. The nanoparticles comprise of docetaxel, PLGA, serum albumin and D-mannitol The developed drug is proposed to be manufactured as enterosoluble tablets, capsules granules, powder, or in any other peroral form.
Type:
Application
Filed:
May 17, 2013
Publication date:
May 21, 2015
Applicants:
UNICHEMPHARM LTD, OY FILANA LTD
Inventors:
Evgenij Severin, Irina Zykova, Victor Gulenko, Maksim Iurchenko