Patents Assigned to Oy Medix Biochemica AB
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Patent number: 11378579Abstract: The present invention relates to a novel MMP-8 activation product such as a MMP-8 middle-part activation product. The invention also relates to detecting such a MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject and to the use thereof for diagnosing diseases which relate to abnormal or elevated levels of activated MMP-8.Type: GrantFiled: May 2, 2019Date of Patent: July 5, 2022Assignees: Oy Medix Biochemica AB, Dentognostics GmbHInventors: Timo Sorsa, Dirk-Rolf Gieselmann, Armi Korvuo, Kurt Maier, Païvi Mäntylä, Ismo Råman, Sinikka Tiisala
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Patent number: 10488415Abstract: MMP-8 activation products are disclosed that have a MMP-8 middle-part activation product having a size between 20-35 kDa. Methods of detecting the MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject are also disclosed. The MMP-8 activation product or activated MMP-8 fragments diagnose diseases based on abnormal or elevated levels of activated MMP-8.Type: GrantFiled: February 27, 2015Date of Patent: November 26, 2019Assignees: OY MEDIX BIOCHEMICA AB, DENTOGNOSTICS GMBHInventors: Timo Sorsa, Dirk-Rolf Gieselmann, Armi Korvuo, Kurt Maier, Päivi Mäntylä, Ismo Råman, Sinikka Tiisala
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Patent number: 10330681Abstract: MMP-8 activation products are disclosed that have a MMP-8 middle-part activation product having a size between 20-35 kDa. Methods of detecting the MMP-8 activation product or activated MMP-8 fragments in a biological sample derived from a subject are also disclosed. The MMP-8 activation product or activated MMP-8 fragments diagnose diseases based on abnormal or elevated levels of activated MMP-8.Type: GrantFiled: February 27, 2015Date of Patent: June 25, 2019Assignees: OY MEDIX BIOCHEMICA AB, DENTOGNOSTICS GMBHInventors: Timo Sorsa, Dirk-Rolf Gieselmann, Armi Korvuo, Kurt Maier, Päivi Mäntylä, Ismo Råman, Sinikka Tiisala
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Publication number: 20120135432Abstract: The invention relates to a diagnostic method for detecting susceptibility to delivery, and to a test kit for this purpose. A low, but higher than baseline level concentration of Insulin-like Growth Factor Binding Protein 1 (IGFBP-1), which is due to leakage from decidual cells, is detected by an immunological assay in a vaginal secretion sample.Type: ApplicationFiled: February 3, 2012Publication date: May 31, 2012Applicant: Oy Medix Biochemica ABInventor: Eeva-Marja RUTANEN
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Patent number: 7892774Abstract: The invention relates to a diagnostic method for detecting susceptibility to delivery, and to a test kit for this purpose. A low, but higher than baseline level concentration of Insulin-like Growth Factor Binding Protein 1 (IGFBP-1), which is due to leakage from decidual cells, is detected by an immunological assay in a vaginal secretion sample.Type: GrantFiled: December 29, 2009Date of Patent: February 22, 2011Assignee: Oy Medix Biochemica ABInventor: Eeva-Marja Rutanen
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Publication number: 20100099117Abstract: The invention relates to a diagnostic method for detecting susceptibility to delivery, and to a test kit for this purpose. A low, but higher than baseline level concentration of Insulin-like Growth Factor Binding Protein 1 (IGFBP-1), which is due to leakage from decidual cells, is detected by an immunological assay in a vaginal secretion sample.Type: ApplicationFiled: December 29, 2009Publication date: April 22, 2010Applicant: Oy Medix Biochemica ABInventor: Eeva-Marja RUTANEN
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Publication number: 20090269782Abstract: The invention relates to a diagnostic method for detecting susceptibility to delivery, and to a test kit for this purpose. A low, but higher than baseline level concentration of Insulin-like Growth Factor Binding Protein 1 (IGFBP-1), which is due to leakage from decidual cells, is detected by an immunological assay in a vaginal secretion sample.Type: ApplicationFiled: July 7, 2009Publication date: October 29, 2009Applicant: Oy Medix Biochemica ABInventor: Eeva-Marja RUTANEN
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Publication number: 20050136490Abstract: The invention relates to a diagnostic method for detecting susceptibility to delivery, and to a test kit for this purpose. A low, but higher than baseline level concentration of Insulin-like Growth Factor Binding Protein 1 (IGFBP-1), which is due to leakage from decidual cells, is detected by an immunological assay in a vaginal secretion sample.Type: ApplicationFiled: January 31, 2005Publication date: June 23, 2005Applicant: OY MEDIX BIOCHEMICA ABInventor: Eeva-Marja Rutanen
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Patent number: 6379972Abstract: An analytical test device and method of use are taught. The device has a perforating sharp tip to contact the sample. The tip has an aperture permitting the sample to flow into a recess of the device without the application of vacuum. In the recess is a test means that is contacted by the sample flowing through the aperture and give the test results.Type: GrantFiled: September 9, 1999Date of Patent: April 30, 2002Assignee: Oy Medix Biochemica ABInventor: Ilkka Kouvonen
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Patent number: 5866432Abstract: The present invention is related to a rapid and reliable method for making chair-side diagnoses of periodontal diseases and especially for predicting the risk of progressing of the periodontal diseases. The diagnosis and prognosis are performed using an immunological test kit by which increased levels of neutrophil gelatinase-related lipocalin (NGAL) derived from polymorphonuclear neutrophilic leucocytes PMNs) is measured.Type: GrantFiled: December 11, 1996Date of Patent: February 2, 1999Assignee: Oy Medix Biochemica ABInventors: Timo Arto Sorsa, Sari Hannele Tikanoja, Leila Christina Lundqvist
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Patent number: 5736341Abstract: Methods and test kits are described which provide a reliable, sensitive and selective assessment of periodontal disease activity, peri-implantitis or HIV(+)-infection/AIDS-disease related periodontal diseases. The preferred methods and test kits are constructed to be easy and rapid chair-side tests. The method is based on the preparation and use of monoclonal antibodies which recognize the active mammalian matrix metalloproteinase-S (MMP-8) and is capable of differentiating between said active matrix metalloproteinase-8 and its inactive proform.Type: GrantFiled: June 7, 1995Date of Patent: April 7, 1998Assignee: Oy Medix Biochemica ABInventors: Timo Arto Sorsa, Sari Hannele Tikanoja, Leila Christina Lundqvist
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Patent number: 5712170Abstract: A test strip for a rapid immunoassay containing specific immunochemical reagent zones (7, 8, 9) is described. The test strip (10) has a backing sheet (1) and attached thereto a receiving end pad (3) and at a distance therefrom a finishing end pad (5). A test membrane (2) is provided between said pads (3, 5). Said membrane (2) is positioned in parallel relationship to said backing (1) at a distance therefrom so that said backing (1) and said membrane (2) limit between themselves an air gap (4) which is open at its edges. Said gap (4) functions as a sheltered reaction chamber for the immunolgical reaction taking place as a liquid is made to flow through said membrane (2). The test strip is simple to manufacture by lamination and easy to use and it is suitable for both diagnostic and environmental immunoassays.Type: GrantFiled: November 14, 1994Date of Patent: January 27, 1998Assignee: Oy Medix Biochemica ABInventors: Ilkka Sakari Kouvonen, Eivor Helena Svens, Sari Hannele Tikanoja, Pekka Antero Turunen, Lauri Markus Sivonen
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Patent number: 5554504Abstract: A rapid diagnostic method for detecting the rupture of fetal membranes is disclosed. The presence of insulin-like growth factor binding protein 1 (IGFBP-1) in a vaginal secretion sample, resulting from the rupture of fetal membranes, is detected with the aid of at least one specific binding substance for IGFBP-1 .Type: GrantFiled: June 30, 1993Date of Patent: September 10, 1996Assignee: OY Medix Biochemica ABInventor: Eeva-Marja Rutanen
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Patent number: D634440Type: GrantFiled: December 23, 2009Date of Patent: March 15, 2011Assignee: Oy Medix Biochemica ABInventor: Kirsi Svärd
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Patent number: D651322Type: GrantFiled: February 3, 2011Date of Patent: December 27, 2011Assignee: Oy Medix Biochemica ABInventor: Kirsi Svärd
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Patent number: D827130Type: GrantFiled: March 29, 2016Date of Patent: August 28, 2018Assignee: OY MEDIX BIOCHEMICA ABInventor: Teemu Penttilä