Abstract: The invention discloses a novel significantly improved carrier protein for pharmaceutical applications: metal ion-stabilized alfa-fetoprotein, AFP. The stabilized AFP serves as a novel universal drug delivery vehicle in formulating drugs to be targeted to cancer cells. Various transition metal ions form non-covalent adducts with AFP and stabilize it against physical and chemical factors in physiological fluids while not affecting its ability to target to AFP receptor-expressing cells.
Type:
Application
Filed:
November 18, 2014
Publication date:
December 22, 2016
Applicant:
Oy Safemed Ltd.
Inventors:
Elena Dudich, Igor Vyacheslavovich Dudich, Lidia Nikolaevna Semenkova, Eduard Tatulov, Timo Korpela