Abstract: The invention relates to a new, spontaneous mouse lymphoma cell line displaying CD19, B220, MHC II, surface IgG2a/kappa chain and MAC-1, which is negative for CD5, animal models of B-cell lymphoma based on said cell line and methods for assessing lymphoma propagation and lymphoma expansion based on said cell line.

Abstract: A technique to generate terahertz radiation is disclosed, where a pump beam (12) is coupled into an optical element (50) made of a medium with non-linear optical properties having plane-parallel front and rear boundary surfaces (51, 52), wherein the pump beam (12) is split into a set of partial pump beams (121) by reflection and/or diffraction on a periodic relief structure (53) of said optical element (50). The partial pump beams travel along a direction at an angle ? that satisfies the velocity matching condition of vp,cs cos(?)=vTHz,f within the given medium, where vp,cs is the group velocity of the pump beam, vTHz,f is the phase velocity of the terahertz radiation and the speed a planar envelope (212) travels toward the front boundary surface (51) of the optical element (50), and angle ? is the angle formed by the pulse front envelope and the phase front of the pump beam.

Abstract: The invention relates to a non-invasive, simple, inexpensive, quick method to assess embryo competence in vitro by detecting nucleic acid-containing extracellular vesicles in the culture medium of the embryo. The culture medium may be fixed before being stained with propidium iodide and analysed by flow cytometry.

Abstract: The non-invasive method of assessing the reducing potential of culture medium of in vitro cultured embryos as part of an ART procedure serves as an alternative or supportive method to assess the viability of in vitro cultured embryos without doing any harm to the embryos.

Abstract: A pump beam (12) is pre-tilted by subjecting the pump beam to pulse-front-tilting, the thus obtained tilted-pulse-front pump beam is then coupled into the nonlinear optical medium. THz radiation is generated in the optical medium by nonlinear optical processes, in particular by optical rectification, by the pump beam. A pulse-front-tilt of the pump beam satisfying the velocity matching condition of vp,cs cos(?)=vTHz,f is induced as a sum of a plurality of pulse-front-tilts separately induced as a partial pulse-front-tilt of the pump beam in subsequent steps. The last step of pulse-front-tilting of the pump beam is performed by coupling the pump beam into the nonlinear optical medium through a stair-step structure (40) formed in an entry surface (51) of the nonlinear optical medium which forms an angle (?) of a given non-zero size with an exit surface (52) of said nonlinear optical medium.

Abstract: A measuring system (100) for data acquisition in soft-field tomography analysis of an object (62) includes transmitting units (63-i), receiving units (65-j), measuring units (67-j), an excitation unit having an alive point (“hot spot”; 81) and a ground point (“cold spot”; 82), a measuring data acquisition unit (85), and a control unit (90). In the operational state, the control unit (90) controls the excitation unit and the measuring data acquisition unit (85); the excitation unit connects to a transmitting unit (63-i), one at a time, to drive the transmitting units (63-i). Transmitting units (63-i) and the receiving units (65-j) couple, one by one, with the object (62) to excite and detect response upon the excitation field, wherein the receiving units (65-j) connect together in pairs to form measuring circuits to characterize the detected response quantitatively by measurement data.

Abstract: This document provides methods and materials for reducing ischemia-reperfusion injury. For example, methods and materials for administering ABA to reduce tissue injury caused by reperfusion following ischemia are provided.

Abstract: A pump beam (12) is subjected to pulse front tilting, and then guided through an imaging optics (30) and then coupled into the nonlinear optical medium through an entry surface of the nonlinear optical medium. THz radiation is generated in the optical medium by nonlinear optical processes, in particular by optical rectification, via the pump beam. The pulse front tilt of the pump beam required to satisfy the velocity matching condition of vp,cs cos(?)=vTHz,f is induced as a sum of a plurality of pulse front tilts, where each pulse front tilt is induced separately as a partial pulse front tilt of the pump beam in subsequent steps. The last step of pulse front tilting of said pump beam (12) is performed by coupling the pump beam (12) into the nonlinear optical medium through a stair-step structure (40) formed in the entry surface of the nonlinear optical medium.

Abstract: The present application relates to generating terahertz radiation, wherein a pump pulse is subjected to pulse front tilting, the thus obtained pump pulse having tilted pulse front is coupled into a nonlinear optical medium and THz pulse is generated by the optical medium in nonlinear optical processes, particularly by means of optical rectification by the pump pulse. The application also relates to a terahertz radiation source (100), comprising a pump source (10) for emitting a pump pulse and a nonlinear optical medium for generating THz pulse. The pump source (10) and the nonlinear optical medium define together a light path, said light path is arranged to guide the pump pulse from the pump source (10) to the nonlinear optical medium. A first optical element (20) having angular-dispersion-inducing property and imaging optics (30) are disposed in the light path after each other in the propagation direction of the pump pulse.

Abstract: The present invention relates to 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine derivatives of the and solvates, hydrates and pharmaceutically acceptable salts thereof, processes for manufacturing of them, the use of them, as well as pharmaceutical compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluents, especially for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia. Said 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine compounds have been identified as new drug candidates for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia.

Abstract: The invention relates to a wide range optical sensor for measuring pH, wherein said optical sensor contains a carrier and one or more p-nitro-phenyl/formaldehyde condensed polymer of formula (I) bounded to said carrier wherein n is 1-20, and Z is H or binding group.

Abstract: This document provides methods and materials for reducing ischemia-reperfusion injury. For example, methods and materials for administering ABA to reduce tissue injury caused by reperfusion following ischemia are provided.

Abstract: The invention relates to a compound having SSAO/VAP-1 inhibitor activity for use in the treatment of hyperalgesia and allodynia implicated in traumatic neuropathy or neurogenic inflammation. Accordingly, the invention relates to a compound having SSAO/VAP-1 inhibitor activity for use in the inhibition of pathological activation and dysfunctions of peptidergic sensory nerves caused by mechanical damage or chemical activation of peptidergic sensory nerves in neurogenic inflammation.

Abstract: The present invention provides for an engineered three dimensional (3D) pulmonary model tissue culture which is free of any artificial scaffold.

Abstract: A new system and method introducing vertebra vectors for the three-dimensional (3D) visualization and its use for the complete 3D characterization and numerical analysis of vertebrae in spinal deformities is covered in this application. A vertebra vector representing its respective vertebra means a simplification of the very complex visual information in digital images and 3D reconstructions provided by the current radiodiagnostic devices, without sacrificing relevant data for the information important to understand the underlying processes in spinal deformation: 3D mathematical data on vertebral size, position, orientation and rotation. A series of vertebra vectors of the thoracic and lumbar spinal region provide the ability of a virtual 3D reconstruction of the spine, in frontal, sagittal and horizontal plane.

Abstract: The invention can be used for setting up high energy and high average power soft x-ray laser equipments. The apparatus of the present invention is provided with a capillary discharge, wherein the spark gap (3) is disposed in water and breakdown of the spark gap (3) is triggered and synchronized by a laser source (16). In order to complete the synchronizing step the apparatus comprises a transformer (12) for monitoring and controlling the decrease of the charging current of the generator, preferably a Marx generator (7), and a triggering circuit (14). The time dependent control of the laser source (16) generating the breakdown of the spark gap (3) is achieved by the triggering circuit (14).

Abstract: The invention is a THz waveguide source (3) having a core (9) of great nonlinear coefficient and of a great absorption. The source (3) is adapted to behave as a waveguide in pumping and also in THz range. The THz waveguide source (3) has a cladding of smaller absorption coefficient in the THz range than that of the core. The solution according to the invention diminishes the influence of absorption, while enhances efficiency of generating THz radiation. The waveguide structure and the tilted pulse front excitation together results a greater interaction length and thus a greater THz generating efficiency. According to the solution of the invention highly efficient compact THz waveguide sources can be realized.

Abstract: A new system and method introducing vertebra vectors for the three-dimensional (3D) visualization and its use for the complete 3D characterization and numerical analysis of vertebrae in spinal deformities is covered in this application. A vertebra vector representing its respective vertebra means a simplification of the very complex visual information in digital images and 3D reconstructions provided by the current radiodiagnostic devices, without sacrificing relevant data for the information important to understand the underlying processes in spinal deformation: 3D mathematical data on vertebral size, position, orientation and rotation. A series of vertebra vectors of the thoracic and lumbar spinal region provide the ability of a virtual 3D reconstruction of the spine, in frontal, sagittal and horizontal plane.

Abstract: A method for milling process simulation performed on a free-formed body is disclosed. In the method a three-dimensional multi-dexel representation of a free-formed body to be processed is generated by using a three-dimensional depth peeling algorithm at a first virtual camera position and a predetermined grid spacing (S110), wherein each of the dexels are stored independently of each other regarding their neighborhood relations, and each of the dexels is associated with at least the following pieces of information: information relating to the spatial position and direction of the dexel, preferably the display coordinates of the dexel and the depth coordinate of the end points of the dexels, geometric information relating to the workpiece surface intersected by the dexel at the starting point and the end point of the dexel.

Abstract: The subject of the present invention are quinazoline derivatives and their pharmaceutically acceptable salts of general formula (I), that inhibit a DNA-repairing enzyme, poly(ADP-ribose) polymerase (PARP), enabling them to be used for the preparation of pharmaceutical compositions for preventing or treating illnesses where PARP-inhibition yields a beneficial effect. In general formula (I) R1 stands for either hydrogen or a group of general formula (a); R2 stands for a) hydrogen or C1-6 alkyl group, if R1 is other than hydrogen, and b) if R1 is hydrogen, then R2 may be a group of general formula (b), (c) or (d). The subject of the present invention also embraces the preparation processes of the compounds described above.