Abstract: A method and device are provided for measuring a level of a clinically relevant analyte (such as glucose) in a fluid (such as blood). The device includes a flow path for conducting said fluid through the device; a detection chamber arranged on said flow path; and detector means arranged to detect analyte levels in the fluid in said chamber, wherein: said detection chamber contains a predetermined amount of an analyte such that that analyte mixes with fluid in the detection chamber to form, at the detector means, a calibration sample of the fluid at a time after the arrival of the fluid in said detection chamber, and said detector means is arranged to detect a first analyte level of an unadulterated sample of the fluid at a first time which is before the formation of said calibration sample and to detect a second analyte level of said calibration sample at a second time which is after the formation of said calibration sample.

Abstract: Methods of doing business and systems for implementing those methods which improve the effectiveness and success of the research and development of technology such as pharmaceuticals, biotechnology, agrochemicals, medical technology, and genomics. The methods include the application of value and cost modeling methodologies to provide a pharmaceutical, biotechnology or genomics research and development organization with information and data which will assist it in making choices and decisions about its prospective products and the manner of research and development thereof in order to realize the greatest economic gain from commercialization of the products.

Abstract: Methods of doing business and systems for implementing those methods which improve the effectiveness and success of the research and development of technology such as pharmaceuticals, biotechnology, agrochemicals, medical technology, and genomics. The methods include the application of value and cost modeling methodologies to provide a pharmaceutical, biotechnology or genomics research and development organization with information and data which will assist it in making choices and decisions about its prospective products and the manner of research and development thereof in order to realize the greatest economic gain from commercialization of the products.

Abstract: A dosing device comprising a dispensing means for dispensing a dose material, and a dose actuation mechanism, in which the dose actuation mechanism comprises a readily deflectable member, and a cascade of at least two pivoted elements, movement of one causing movement of the other, wherein the deflectable member is moveable by the user, and its movement is transferred to the first of the cascade of pivoted elements, so as to actuate the dispensing means. A first biasing means communicates with one pivoted element so that as movement is transferred between the pivoted elements, energy stored in the first biasing means is released to increase the force associated with the movement. A dose actuating mechanism for use in a dosing inhaler is also provided.