Abstract: The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.

Abstract: The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.

Abstract: The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.

Abstract: The present invention is directed to providing antimicrobial compositions consisting of a polymeric material and, embedded therein, an antimicrobial compound. The antimicrobial compound contains at least one quaternary ammonium group, at least one hydrocarbon chain comprising a minimum of 10 carbon atoms and a maximum of 24 carbon atoms, and one or more anions to balance the charge of the quaternary ammonium groups. The invention is also directed to a method of making antimicrobial compositions containing an antimicrobial compound embedded in a polymeric material.

Abstract: In one embodiment, the invention provides an ion having the formula: (I) In another embodiment, the invention provides a method for modulating potassium, sodium, and cyclic nucleotide-modulated ion channels in a mammal in need thereof. In a further embodiment, the invention provides a method for modulating ligand-gated ion channels or transient receptor potential channels in a mammal in need thereof. The methods comprise administering an ion having the formula described above.

Abstract: The present invention provides a system and method for predicting and preventing unauthorized intrusion in a computer configuration. Preferably, the invention comprises a communication network to which at least two computing devices connect, wherein at least one of the computing devices is operable to receive data transmitted by the other computing device. The invention further comprises a database that is accessible over the network and operable to store information related to the network. A vulnerability assessment component is provided that is operable to execute a command over the communication network, and a data monitoring utility operates to monitor data transmitted over the communication network as the vulnerability assessment component executes commands.

Abstract: The invention relates to an antimicrobial surface having the formula SS?(V+2?W)X wherein: SS represents a solid surface, said solid surface comprising hydroxyl groups attached to a carbon atom in the unmodified state thereof; V+2 represents a doubly positively charged moiety having the formula —+NR2-T-NR2+—, or 1,4-diazoniabicyclo[2.2.2]octane; T represents a saturated or unsaturated straight-chain hydrocarbon having 1-24 carbon atoms; R represents a saturated or unsaturated hydrocarbon group having 1-24 carbon atoms; phenyl; or benzyl; W represents a saturated or unsaturated straight-chain hydrocarbon having 10-24 carbon atoms; and X represents an anion that balances the charge of V wherein a nitrogen atom of V replaces at least some of the hydroxyl groups.

Abstract: These and other objectives will be apparent to those having ordinary skill in the art have been achieved by providing an antimicrobial surface having formula 1: SS—(Ua—V+b1—W)b2dX?eformula 1 wherein: SS represents a modified solid surface that comprises a hydroxyl group in the unmodified state thereof; a represents 0 or 1; U represents —Y1T-; Y1 represents —O—, —S—, or —NQ-; Q represents H; a saturated or unsaturated hydrocarbon group having 1-24 atoms; phenyl; or benzyl; T represents a saturated or unsaturated hydrocarbon chain having 1-24 atoms; V represents a positively charged moiety; b1 represents 1 or 2; b2 represents 1-3; W represents LZ; L represents a saturated or unsaturated hydrocarbon chain having 10-24 atoms; Z represents —H, —OH, —SH, —F, —Cl, —Br, —I, —OR, —HN(O)CQ, or —O(O)CQ; R represents a saturated or unsaturated hydrocarbon group having 1-24 carbon atoms; phenyl; or benzyl; X represents an anion; d represents 1 or 2; and e represents 1-3; wherein b1×b2=d×e.

Abstract: Controlled chemical etching of rotating metal substrates has been shown to be a feasible and economic method for the reproducible production of thin, reactive metallic foils such as copper foils. Foils thus prepared react readily with chemical substances, apparently by chemisorption. The organic-metal assemblies exhibit the same corrosion and wetting behavior as those prepared by other processes, and they readily undergo additional functional group transformations.

Abstract: The compounds 5'-deoxy-5'-(hydroxyethylthio)adenosine (HETA); 5'-deoxy-5'-(monofluoroethylthio)adenosine (MFETA); 5'-deoxy-5'-(chloroethylthio)adenosine (CETA); 5'-deoxy-5'-(bromoethylthio)adenosine (BETA); 5-deoxy-5-(monofluoroethylthio)ribose (MFETR); 5-deoxy-5-(chloroethylthio)ribose (CETR); 5-deoxy-5-(bromoethylthio)ribose (BETR) and 5-deoxy-5-(hydroxyethylthio)ribose (HETR), are described as well as their uses in treating infections caused by 5'-deoxy-5'-methylthioadenosine (MTA) phosphorylase-containing pathogenic microorganisms; in treating infections caused by 5-deoxy-5-methylthioribose (MTR) kinase-containing pathogenic microorganism; and for treating neoplastic diseases.

Abstract: Purine analogs sinefungin, formycin B and 9-deazainosine or its pharmaceutically aceptable acid addition salts are usful in treating African human and veterinary trypanosomiases.