Abstract: A squeezeable container for holding and dispensing decontaminating powder is disclosed. The squeezeable container comprises a brush assembly and gripping means. The brush assembly is attached to the top section of the container in a screw-like manner, and comprises a brush formed of bristles which have a portion that is heat set so as to be held together in a semi-rigid manner. The bristles are arranged to form a reservoir within the brush assembly. The reservoir has an exit section closed off by the semi-rigid bristles, and an entrance section closed off by a plug member. The gripping means has a first end attached to the plug member and a second end extending out of the semi-rigid bristles. The pulling of the gripping means removes the plug from the dispenser and opens the brush reservoir. A squeezing action of the container puffs the powder within the container into the brush reservoir, and movement of brush dispenses the powder over any designed contaminated area.

Abstract: A transdermal drug delivery system with a dual permeation enhancer is described. The transdermal system comprises a body that contains supplies of drug and a dual permeation enhancer comprising sucrose cocoate and methyl laurate, and has a basal surface that contacts an area of skin and transmits the drug and the dual permeation enhancer to the area for absorption thereby. A method for coadministering a drug and a dual permeation enhancer comprising sucrose cocoate and methyl laurate is also described.

Abstract: The present invention is directed to a transdermal delivery system for an active substance. The active substance is estrogen or its derivatives and preferably is 17-beta-estradiol. The system comprises an impermeable backing layer and a matrix affixed thereto. The matrix comprises, on a weight percentage basis, from about 60 to about 95% of an adhesive polymer, from about 5 to about 20% of a solvent, from about 0.2 to about 4% of a skin penetration enhancer, and from about 0.5 to about 5% of the active substance. The system is free of any discrete permeable, polymeric, diffusion-controlling membrane.