Abstract: A managed detection and response system includes an enterprise network including a plurality of endpoints in which an endpoint agent is installed or not installed to detect and block malware through a machine learning algorithm and a plurality of network security solutions for applying a predetermined security policy to the plurality of endpoints, a threat analysis server configured to generate an IOC by analyzing the detected and blocked malware in any one of the plurality of endpoints and establish the security policy according to the generated IOC to be linked with a corresponding network security solution of the plurality of network security solutions, and a cloud server that connects the enterprise network and the threat analysis server.