Patents Assigned to PAION UK Limited
  • Short-acting benzodiazepine salts and their polymorphic forms
    Patent number: 9193730
    Abstract: The invention relates to besylate salts of the compound of formula (I): Methods of preparing the salts, and their use as medicaments, in particular for sedative or hypnotic, anxiolytic, muscle relaxant, or anticonvulsant purposes is also described.
    Type: Grant
    Filed: July 10, 2007
    Date of Patent: November 24, 2015
    Assignee: PAION UK Limited
    Inventors: Gary Stuart Tilbrook, Louisa Jane Cubitt
  • Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-A][1,4]benzodiazepine-4-YL]propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
    Patent number: 9156842
    Abstract: The invention concerns a new process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]-propionic acid methyl ester or 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]propionic acid methyl ester benzene sulfonate (P) which comprises reacting 3-[(S)-7-bromo-2-((R and/or S)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]-propionic acid methyl ester of formula (EM) with an oxidizing agent and optionally treating the reaction product under acidic conditions, such as to produce the compound of formula (F) or the compound (P), and new compounds useful as starting material or as intermediate for performing that process.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: October 13, 2015
    Assignee: PAION UK LIMITED
    Inventors: Gary Stuart Tilbrook, Andreas Schumacher, René Emmenegger
  • COMPOSITIONS COMPRISING SHORT-ACTING BENZODIAZEPINES
    Publication number: 20150148338
    Abstract: A composition is provided with a benzodiazepine and at least one hygroscopic excipient, in particular lactose and/or dextran.
    Type: Application
    Filed: May 22, 2013
    Publication date: May 28, 2015
    Applicant: PAION UK LIMITED
    Inventors: John Aitken Graham, Alan James Baillie, Kevin Richard Ward, Thomas Peacock
  • Short-acting benzodiazepine salts and their polymorphic forms
    Patent number: 8642588
    Abstract: The invention relates to esylate salts of the compound of formula (I): Methods of preparing the salts, and their use as medicaments, in particular for sedative or hypnotic, anxiolytic, muscle relaxant, or anticonvulsant purposes is also described.
    Type: Grant
    Filed: July 10, 2007
    Date of Patent: February 4, 2014
    Assignee: PAION UK Limited
    Inventors: Gary Stuart Tilbrook, Louisa Jane Cubitt
  • PROCESS FOR PREPARING 3-[(4S)-8-BROMO-1-METHYL-6-(2-PYRIDINYL)-4H-IMIDAZO[1,2-A][1,4]BENZODIAZEPINE-4-YL]PROPIONIC ACID METHYL ESTER OR THE BENZENE SULFONATE SALT THEREOF, AND COMPOUNDS USEFUL IN THAT PROCESS
    Publication number: 20120330007
    Abstract: The invention concerns a new process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]-propionic acid methyl ester or 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]propionic acid methyl ester benzene sulfonate (P) which comprises reacting 3-[(S)-7-bromo-2-((R and/or S)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]-propionic acid methyl ester of formula (EM) with an oxidizing agent and optionally treating the reaction product under acidic conditions, such as to produce the compound of formula (F) or the compound (P), and new compounds useful as starting material or as intermediate for performing that process.
    Type: Application
    Filed: September 15, 2010
    Publication date: December 27, 2012
    Applicant: PAION UK Limited
    Inventors: Gary Stuart Tilbrook, Andreas Schumacher, René Emmengger
  • ADMINISTRATION SCHEME OF POLAR OPIOID METABOLITES FOR POST-OPERATIVE PAIN MANAGEMENT
    Publication number: 20110294843
    Abstract: Administration scheme of an analgesically active polar metabolite of an opioid or the salt thereof for the manufacture of a medicament for the treatment of pain after medical operation, whereas the medicament is administered at least once before the end of the medical operation.
    Type: Application
    Filed: October 16, 2008
    Publication date: December 1, 2011
    Applicant: PAION UK Limited
    Inventors: Mariola S+e,uml o+ee hngen, Heimo Stroissnig
  • SHORT-ACTING BENZODIAZEPINE SALTS AND THEIR POLYMORPHIC FORMS
    Publication number: 20100081647
    Abstract: The invention relates to besylate salts of the compound of formula (I): Methods of preparing the salts, and their use as medicaments, in particular for sedative or hypnotic, anxiolytic, muscle relaxant, or anticonvulsant purposes is also described.
    Type: Application
    Filed: July 10, 2007
    Publication date: April 1, 2010
    Applicant: PAION UK Limited
    Inventors: Gary Stuart Tilbrook, Louisa Jane Cubitt