Abstract: Improved laser capture microdissection systems and related methods are provided by using an imaging system for imaging the tissue sample from which a cell sample is to be obtained, the imaging system comprising a sensor having one or more receptors, and an image transfer medium to scale the one or more receptors to an object field of view.

Abstract: An imaging system and methodology is provided to facilitate optical imaging performance. The system includes a sensor having one or more receptors and an image transfer medium to scale the sensor and receptors to an object field of view. A computer, memory, and/or display associated with the sensor provides storage and/or display of information relating to output from the receptors to produce and/or process an image, wherein a plurality of illumination sources can also be utilized in conjunction with the image transfer medium. The image transfer medium can be configured as a k-space filter that correlates a pitch associated with the receptors to a diffraction-limited spot within the object field of view, wherein the pitch can be unit-mapped to about the size of the diffraction-limited spot within the object field of view.