Abstract: Substrates comprising a solid support, a ligand, and a linker comprising at least one C, O, N, or S atom covalently connecting the solid support to the ligand, are disclosed, along with methods of using and making the substrates, and devices including the substrates.

Abstract: Corrugated fluid treatment packs and methods of making corrugated fluid treatment packs are disclosed. The fluid treatment packs may comprise a non-woven fibrous structure having a tubular configuration, a longitudinal axis, and circumferentially extending corrugations.

Abstract: Fluid filter elements and assemblies are used to separate contaminants from a fluid, such as oil or fuel, prior to reaching an engine. Fluid filter assemblies may comprise a housing, a filter element, and a filter head. The filter element may be disposed within the filter housing and enclosed by the filter head. Fluid enters the housing and passes through the filter element. The fluid may then exit the assembly. A connector may be used to connect the filter element to the filter head to ensure proper installation and simplify removal of a fouled filter element. The connector permits removable coupling of the filter element to the filter head and resists unintentional disengagement to securely couple the filter element to the filter head.

Abstract: Intravenous fluid filter devices including a filter comprising spaced apart first and second filter elements comprising hydrophilic membranes and providing inside-out flow, and methods of using the devices, are disclosed.

Abstract: Devices and methods for separating plasma from biological fluids such as blood and blood products are disclosed.

Abstract: A disconnectable connector assembly is provided, including a first fitting having a movable stem therein, the stem being movable from one end toward the other end of the first fitting; a valve releasably attached to the stem, the valve including legs engageable with a lip; a second fitting connected to the first fitting, the second fitting including the lip, the second fitting being in fluid communication with the stem and the first fitting when the stem is in a first position, and wherein fluid flow between the second fitting and the stem and the first fitting is blocked when the stem is in a second position; the first fitting being disconnectable from the second fitting after the stem has been moved and the valve is released from the stem with the legs engaged with the lip when the first and second fittings are disconnected.

Abstract: A filter apparatus includes a housing assembly and a filter arrangement mounted in the housing assembly. The filter arrangement includes a reusable core assembly, a first filter assembly removably mounted around the exterior of the reusable core assembly, and a bypass assembly removably mounted to the reusable core assembly at least partially in the interior of the core assembly. The bypass assembly includes a bypass valve mechanically connected to a second filter assembly.

Abstract: The invention relates to a module for processing a fluid having a body of wound layers of a sheet material, the body having inner and outer surfaces, first and second end faces and a passage extending along the winding axis of said body in fluid communication with the inner surface, the sheet material having openings forming at least three types of channels, the channels extending from the inner surface to the outer surface, a first type of channel being open at the outer surface of the body and closed at the other end, a second type of channel being open at the inner surface of the body, in fluid communication with said passage and closed at the other end, a third type of channel being closed at both ends thereof and positioned such as to receive fluid from one or more channels of the first or second type.

Abstract: Systems for filtration are disclosed. A feed mixture including at least one liquid component and at least one solid component and a flow of gas may be directed to a filter element and filtrate and gas may be passed through a filter medium from a feed fluid side to a filtrate side.

Abstract: Apparatus and method for detecting the presence or amount or rate of binding of an analyte in a sample solution is disclosed. The apparatus includes an optical assembly having first and second reflecting surfaces separated by a distance “d” greater than 50 nm, where the first surface is formed by a layer of analyte-binding molecules, and a light source for directing a beam of light onto said first and second reflecting surface. A detector in the apparatus operates to detect a change in the thickness of the first reflecting layer resulting from binding of analyte to the analyte-binding molecules, when the assembly is placed in the solution of analyte, by detecting a shift in phase of light waves reflected from the first and second surfaces.

Abstract: A fluid treatment arrangement may include a fluid treatment unit having a multilayer structure. The multilayer structure may include at least one feed layer, at least one permeate layer, and at least one layer of a permeable fluid treatment medium between the feed layer and the permeate layer. The fluid treatment unit may further include a thermoset which holds the layers together and forms at least a portion of a first end surface of the fluid treatment unit. The fluid treatment arrangement may also include a thermoplastic sheet which overlies the first end surface of the fluid treatment unit. The thermoset directly bonds to the thermoplastic sheet.

Abstract: A method for detecting bacteria in biological fluids is provided, the method comprising placing a biological fluid possibly containing bacteria in a container, the container including a detergent for reducing the respiration of blood cells, and a bacterial growth promoter, and measuring and/or detecting the level of glucose in the biological fluid in the container, over a period of time. A system for carrying out the method is also provided.

Abstract: Filtration systems may comprise a manifold having a fitting and a filter having a fitting. One of the manifold fitting and the filter fitting may comprise a nozzle including a tip portion having a contact surface. The other of the manifold fitting and the filter fitting may comprise a receptacle which receives the nozzle and has a contact surface. The filter may be removably mountable to the manifold with the filter fitting detachably engaging the manifold fitting and the contact surface at the tip portion of the nozzle abutting and sealing against the contact surface of the receptacle to prevent leakage at the end of the nozzle.

Abstract: A filter module is formed of wound filter material having openings wherein the boundary surfaces of the openings constitute flow-through surfaces. The openings of the wound layers of the filter material form channels angled relative to the winding axis, wherein one group thereof opens at the outer peripheral surface of the roll and the other group opens at the inner peripheral surface of the roll and wherein the channels on the other end, respectively, are closed and wherein the channels, angled relative to the winding axis, are separated from one another by filter material, and wherein the inner area of the roll has a central channel arranged around a winding axis.

Abstract: Intravenous fluid filter devices including a filter comprising spaced apart first and second filter elements comprising hydrophilic membranes and providing inside-out flow, and methods of using the devices, are disclosed.

Abstract: Devices, systems, and methods for depleting fluids of immunoglobulins and leukocytes are disclosed.

Abstract: The present invention relates to a filter module comprising a body of wound layers of sheet material, with an inner and outer peripheral surface, a winding axis and a passage within the body, the sheet material having a plurality of openings forming at least two types of channels within the wound layers, the channels extending in a direction from the inner peripheral surface to the outer peripheral surface, a first type of channels in fluid communication with the outer periphery and closed at the end toward the inner periphery, a second type of channels in fluid communication with the inner periphery and closed at the end toward the outer periphery, the two types of channels separated by portions of sheet material, one of the types of channels being outlet channels and being covered by a filter material.

Abstract: A filter module comprises a body of wound layers of sheet material, said body having inner and outer peripheral surfaces and a winding axis and a passage extending along the winding axis and in fluid communication with the inner peripheral surface, the sheet material having openings forming two channel types extending from the inner to the outer peripheral surfaces, a first channel type open at the outer peripheral surface and closed adjacent to the inner peripheral surface, a second channel type open at the inner peripheral surface, in fluid communication with the passage and closed adjacent to the outer peripheral surface, the two channel types separated from each other by sheet material, one channel type communicating with a module port, the other channel type communicating with another module port, wherein a majority of openings forming the inlet channels incompletely register with corresponding openings of an adjacent layer.

Abstract: Methods and systems for filtration are disclosed. A feed mixture including at least one liquid component and at least one solid component and a flow of gas may be directed to a filter element and filtrate and gas may be passed through a filter medium from a feed fluid side to a filtrate side. The gas loosens and removes foulants accumulating within and on the upstream surface of the filter medium. The gas and filtrate may be separated from one another after passing through the filter medium.

Abstract: Corrugated fluid treatment packs and methods of making corrugated fluid treatment packs are disclosed. The fluid treatment packs may comprise a non-woven fibrous structure and/or porous membrane having a tubular configuration and a longitudinal axis, the fibrous structure and/or porous membrane being corrugated to define at least one crest, at least one trough, and at least one corrugation, each corrugation including first and second webs, the first and second webs extending into one another along a crest or a trough. The crests, troughs, and corrugations may include webs may which extend circumferentially or helically.